Protein Alignment CG31183 and GUCY1A2

DIOPT Version :10

• Sequence 1: NP_650505.2
• Gene: CG31183 / 41927
• FlyBaseID: FBgn0051183
• Length: 1417
• Species: Drosophila melanogaster
• Sequence 2: NP_001243353.1
• Gene: GUCY1A2 / 2977
• HGNCID: 4684
• Length: 763
• Species: Homo sapiens
• Alignment Length: 810
• Identity: 219/810 - (27%)
• Similarity: 325/810 - (40%)
• Gaps: 219/810 - (27%)

  Fly   439 RRMWNRSFTGITGNVTIDANGD---RLSAYSLLDMNPTTGRFEIVAHFLHNRLEF-EANKEIHWA 499
            ||:..|.      .|.:|:.|:   ||:|.|...:..|..|  .:.::.|..:.: :|.|..|..
Human    77 RRVQRRR------RVNLDSLGESISRLTAPSPQTIQQTLKR--TLQYYEHQVIGYRDAEKNFHNI 133

  Fly   500 GDREEAPPDRPICGY------------DGAL-CPDNSLPGYAILSIVLGTMVVVMAVCF---FFG 548
            .:|         |.|            .|.| |..|          :||.....:...|   ||.
Human   134 SNR---------CSYADHSNKEEIEDVSGILQCTAN----------ILGLKFEEIQKRFGEEFFN 179

  Fly   549 YRHYIAEAEINSMSWKVSLEDVMFR--DAAERGLRGSFHS---------LVKQSSQLTLM----- 597
            ...:..|..:.::..  :|:| .|.  ||....:|.||..         |.|:..:.|||
Human   180 ICFHENERVLRAVGG--TLQD-FFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLMLHYFH 241

  Fly   598 SEDMVSINGDRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGAC 662
            ...:|.       |..:||.:.:...|..::|: |:.:....|..::....:.          :|
Human   242 PHHIVG-------FAMLGMIKAAGKKIYRLDVE-VEQVANEKLCSDVSNPGNC----------SC 288

  Fly   663 LDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLS-----------LMHDIVRGMQFLHSSDIR 716
            |    :||:.| |...::...|.....|:....|:|           ||.|  ..|..|...:
Human   289 L----TFLIKE-CENTNIMKNLPQGTSQVPADLRISINTFCRAFPFHLMFD--PSMSVLQLGE-- 344

  Fly   717 SHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNR 781
              |..|...|  |:..|||..|.         |::.|...|........:|  :.|.::|.:
Human   345 --GLRKQLRC--DTHKVLKFEDC---------FEIVSPKVNATFERVLLRL--STPFVIRTK--- 391

  Fly   782 PPE--GTQKGD--VYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPEL 842
             ||  |::..|  :...|.::| :.......:||....:|     ::.:.|...|....|..
Human   392 -PEASGSENKDKVMEVKGQMIH-VPESNSILFLGSPCVDK-----LDELMGRGLHLSDIPIH--- 446

  Fly   843 EPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEEL 907
                |...|:..:                            .|.....|.|.|||:    .|:..
Human   447 ----DATRDVILV----------------------------GEQAKAQDGLKKRMD----KLKAT 475

  Fly   908 VEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPM 972
            :|...|...|||||...|||.:.|..||.||..||.|.|..||.||:.||||||||||.|:.|||
Human   476 LERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPM 540

  Fly   973 QVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALL------- 1030
            ||:..||:|||.||......|:||||||||||.|.:||. |....||:.||.:||.::
Human   541 QVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLH-RKSLCHAKPIALMALKMMELSEEVL 604

  Fly  1031 ------------EAVHNFRI-------HHRPEDRL---KLRIGLHTGACVAGVVGLKMPRYCLFG 1073
                        |.:.:|.:       .|:.|..|   |:|||:|:|:.:|||||::||||||||
Human   605 TPDGRPIQPQRSELLFSFPVSIQLVPDQHQSETDLGTEKMRIGIHSGSVLAGVVGVRMPRYCLFG 669

  Fly  1074 DTVNTASRMESNGEALKIHISETTKEAL--DEFGTFVTTRRGFVPMKGKGEM--LTYWLE---GE 1131
            :.|..||:.||.....:|::|.||.:.|  :|..||:...|..:|.....|:  :.|:||   |.
Human   670 NNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGP 734

  Fly  1132 VPRPNSLISPSKL---------MLTRRSSL 1152
            .| |...:|.|::         |..|.:||
Human   735 KP-PKPSLSSSRIKKVSYNIGTMFLRETSL 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_650505.2	PBP1_NPR-like	87..493	CDD:380596	13/57 (23%)
		PK_GC-A_B	589..883	CDD:270944	55/313 (18%)
		HNOBA	<890..938	CDD:462234	19/47 (40%)
		CYCc	917..1108	CDD:214485	101/221 (46%)
GUCY1A2	NP_001243353.1	HNOB	<159..270	CDD:462233	27/131 (21%)
		HNOBA	316..503	CDD:462234	53/254 (21%)
		Guanylate_cyc	514..729	CDD:425528	90/215 (42%)