DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and GUCY1A2

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_001243353.1	Gene:	GUCY1A2 / 2977	HGNCID:	4684	Length:	763	Species:	Homo sapiens

Alignment Length:	817	Identity:	218/817 - (26%)
Similarity:	321/817 - (39%)	Gaps:	233/817 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   439 RRMWNRSFTGITGNVTIDANGD---RLSAYSLLDMNPTTGRFEIVAHFLHNRLEF-EANKEIHWA 499
            ||:..|.      .|.:|:.|:   ||:|.|...:..|..|  .:.::.|..:.: :|.|..|..
Human    77 RRVQRRR------RVNLDSLGESISRLTAPSPQTIQQTLKR--TLQYYEHQVIGYRDAEKNFHNI 133

  Fly   500 GDREEAPPDRPICGY------------DGAL-CPDNSL---------------------PGYAIL 530
            .:|         |.|            .|.| |..|.|                     ....:|
Human   134 SNR---------CSYADHSNKEEIEDVSGILQCTANILGLKFEEIQKRFGEEFFNICFHENERVL 189

  Fly   531 SIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQSSQLT 595
            ..|.||:     ..||.|: ..:.|....|...:.:||...|              |.|:..:.|
Human   190 RAVGGTL-----QDFFNGF-DALLEHIRTSFGKQATLESPSF--------------LCKELPEGT 234

  Fly   596 LM-----SEDMVSINGDRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHL 655
            ||     ...:|.       |..:||.:.:...|..::|: |:.:....|..::....:.
Human   235 LMLHYFHPHHIVG-------FAMLGMIKAAGKKIYRLDVE-VEQVANEKLCSDVSNPGNC----- 286

  Fly   656 VKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLS-----------LMHDIVRGMQF 709
                 :||    :||:.| |...::...|.....|:....|:|           ||.|  ..|..
Human   287 -----SCL----TFLIKE-CENTNIMKNLPQGTSQVPADLRISINTFCRAFPFHLMFD--PSMSV 339

  Fly   710 LHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPEL 774
            |...:    |..|...|  |:..|||..|.         |::.|...|........:|  :.|.:
Human   340 LQLGE----GLRKQLRC--DTHKVLKFEDC---------FEIVSPKVNATFERVLLRL--STPFV 387

  Fly   775 LRVEHNRPPE--GTQKGD--VYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQ 835
            :|.:    ||  |::..|  :...|.::| :.......:||....:|     ::.:.|...|...
Human   388 IRTK----PEASGSENKDKVMEVKGQMIH-VPESNSILFLGSPCVDK-----LDELMGRGLHLSD 442

  Fly   836 KPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELY 900
            .|..       |...|:..:                            .|.....|.|.|||:
Human   443 IPIH-------DATRDVILV----------------------------GEQAKAQDGLKKRMD-- 470

  Fly   901 ANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAI 965
              .|:..:|...|...|||||...|||.:.|..||.||..||.|.|..||.||:.||||||||||
Human   471 --KLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAI 533

  Fly   966 SAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALL 1030
            .|:.|||||:..||:|||.||......|:||||||||||.|.:||. |....||:.||.:||.::
Human   534 CAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLH-RKSLCHAKPIALMALKMM 597

  Fly  1031 -------------------EAVHNFRI-------HHRPEDRL---KLRIGLHTGACVAGVVGLKM 1066
                               |.:.:|.:       .|:.|..|   |:|||:|:|:.:|||||::|
Human   598 ELSEEVLTPDGRPIQPQRSELLFSFPVSIQLVPDQHQSETDLGTEKMRIGIHSGSVLAGVVGVRM 662

  Fly  1067 PRYCLFGDTVNTASRMESNGEALKIHISETTKEAL--DEFGTFVTTRRGFVPMKGKGEM--LTYW 1127
            |||||||:.|..||:.||.....:|::|.||.:.|  :|..||:...|..:|.....|:  :.|:
Human   663 PRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREELPDNFPKEIPGICYF 727

  Fly  1128 LE---GEVPRPNSLISPSKL---------MLTRRSSL 1152
            ||   |..| |...:|.|::         |..|.:||
Human   728 LEVRTGPKP-PKPSLSSSRIKKVSYNIGTMFLRETSL 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	15/62 (24%)
		ANF_receptor	108..473	CDD:279440	10/36 (28%)
		PK_GC-A_B	589..883	CDD:270944	55/313 (18%)
		Pkinase_Tyr	613..877	CDD:285015	49/278 (18%)
		HNOBA	<893..938	CDD:285003	18/44 (41%)
		CYCc	917..1108	CDD:214485	101/221 (46%)
		Guanylate_cyc	944..1130	CDD:278633	93/221 (42%)
GUCY1A2	NP_001243353.1	HNOB	<159..270	CDD:285002	26/138 (19%)
		HNOBA	316..503	CDD:285003	53/254 (21%)
		CYCc	485..705	CDD:214485	100/220 (45%)
		Guanylate_cyc	514..729	CDD:278633	90/215 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810