Protein Alignment CG31183 and Gucy2c

DIOPT Version :10

• Sequence 1: NP_650505.2
• Gene: CG31183 / 41927
• FlyBaseID: FBgn0051183
• Length: 1417
• Species: Drosophila melanogaster
• Sequence 2: NP_037302.1
• Gene: Gucy2c / 25711
• RGDID: 2771
• Length: 1072
• Species: Rattus norvegicus
• Alignment Length: 1068
• Identity: 339/1068 - (31%)
• Similarity: 518/1068 - (48%)
• Gaps: 207/1068 - (19%)

  Fly   151 FEIY----TQWPEVNA-VFGLPCEY------VLAPISR----YADVWQVPVLTTGGNAKEFNKKS 200
            |::|    ..:|.::| .|||.|:|      :|.|..:    ..|.|
  Rat   128 FQMYLDTELNYPMISAGSFGLSCDYKETLTRILPPARKLMYFLVDFW------------------ 174

  Fly   201 ESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHS 265
                        :|||      |...:|:| .::.:|:|.:..    ..||..|.|:...:...|
  Rat   175 ------------KVNN------APFKTFSW-NSSYVYKNGSEP----EDCFWYLNALEAGVSYFS 216

  Fly   266 VYQLGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELF 330
            .. |.|............:|.....:|.:::||..|::...:   ..:|.:.|  :.|.|.::||
  Rat   217 EV-LSFKDVLRRSEQFQEILMGRNRKSNVIVMCGTPETFYNV---KGDLKVAD--DTVVILVDLF 275

  Fly   331 SRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKY--NYTF 393
            |.        .|.::||     ||.:....:|.:|                  :..||:  |.:.
  Rat   276 SN--------HYFEDDT-----RAPEYMDNVLVLT------------------LPPEKFIANASV 309

  Fly   394 SDNEPI--SAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTID 456
            |...|.  |.|..::.:|.||:.:.| ::..|:...:|.|    ...|...|.:|.|:.|.||:|
  Rat   310 SGRFPSERSDFSLAYLEGTLLFGHML-QTFLENGESVTTP----KFARAFRNLTFQGLEGPVTLD 369

  Fly   457 ANGDRLSAYSLLDMNPTTGRFEI-VAHFLHNR--LEFEANKEIHWAGDREEAPPDRPICGYDGAL 518
            .:||..:...||.::..|.:::: :|:..|..  :....:....|...|
  Rat   370 DSGDIDNIMCLLYVSLDTRKYKVLMAYDTHKNQTIPVATSPNFIWKNHR---------------- 418

  Fly   519 CPDNSLPGYA--ILSIVLGTM---VVVMAVCFFFGYRHYIAEAEINSMSWK-VSLEDVMFRDAAE 577
            .| |.:||..  ||.|.:.|:   |||:.:......|.|..:.|:....|. :..|::
  Rat   419 LP-NDVPGLGPQILMIAVFTLTGIVVVLLLIALLVLRKYRRDHELRQKKWSHIPSENI------- 475

  Fly   578 RGLRGSFHSLVKQSSQLTLMSED---MVSINGDRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTRS 639
                  |.....:::.::|..:|   ..:|...||.     .:.|.||.:|  ::.:..|..:..
  Rat   476 ------FPLETNETNHVSLKIDDDRRRDTIQRVRQC-----KYDKKKVILK--DLKHCDGNFSEK 527

  Fly   640 LMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQ------LDWMFRLS 698
            ..:||.::....:.:|.||||......|.|.:.|||.:|||:::| |:...      :||.|::|
  Rat   528 QKIELNKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCERGSLREVL-NDTISYPDGTFMDWEFKIS 591

  Fly   699 LMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAY 763
            :::||.:||.:||||.|..||.|||:|||||||.|:||||||                 |||...
  Rat   592 VLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFG-----------------CNSILP 639

  Fly   764 WSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKG 828
            ..|.|||||     ||.|....:||||||:|.||..||..|:..||...|..:.  ::|..:...
  Rat   640 PKKDLWTAP-----EHLRQATISQKGDVYSFSIIAQEIILRKETFYTLSCRDQN--EKIFRVENS 697

  Fly   829 YNPHRMQKPFRPE--LEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRR----FNKDNETG 887
            |.    .|||||:  ||...:.:.::..:::.||.|||.:||||..::|.:.:    |: |.:..
  Rat   698 YG----TKPFRPDLFLETADEKELEVYLLVKSCWEEDPEKRPDFKKIESTLAKIFGLFH-DQKNE 757

  Fly   888 NIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQV 952
            :.:|.|::|::||:.|||.|||||||.|..|:.:.:.|.:.|||:.|...|.....|..|.:::|
  Rat   758 SYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFMLLPRLVVKSLKEKGIVEPELYEEV 822

  Fly   953 TIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQ 1017
            |||||||||||.|...||||:||..|||:|..||.||::.||||||||||||:|.||||:||||:
  Rat   823 TIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHDVYKVETIGDAYVVASGLPMRNGNR 887

  Fly  1018 HAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRM 1082
            ||.:|:::||.:|..:..|.:.|.|...:.:|||:|:|.|.|||||:||||||||||||||||||
  Rat   888 HAVDISKMALDILSFMGTFELEHLPGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRM 952

  Fly  1083 ESNGEALKIHISETTKEALDEFG-TFVTTRRGFVPMKGKGEMLTYWLEGEVPRPNSLISPSKLML 1146
            ||.|..|:||:|.:|...|.... .|:...||...:||:|...||||.|...:..:|.:|
  Rat   953 ESTGLPLRIHMSSSTIAILRRTDCQFLYEVRGETYLKGRGTETTYWLTGMKDQEYNLPTP----- 1012

  Fly  1147 TRRSSLKQPQRSQSHNLHKQYSELVVAS 1174
                    |.......|..::|:::|::
  Rat  1013 --------PTVENQQRLQTEFSDMIVSA 1032

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_650505.2	PBP1_NPR-like	87..493	CDD:380596	76/363 (21%)
		PK_GC-A_B	589..883	CDD:270944	106/308 (34%)
		HNOBA	<890..938	CDD:462234	22/47 (47%)
		CYCc	917..1108	CDD:214485	104/191 (54%)
Gucy2c	NP_037302.1	Periplasmic_Binding_Protein_type1	34..414	CDD:471960	76/368 (21%)
		Protein Kinases, catalytic domain	479..749	CDD:473864	105/305 (34%)
		CYCc	787..978	CDD:214485	104/190 (55%)