DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and Gucy1b2

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	XP_011243363.2	Gene:	Gucy1b2 / 239134	MGIID:	2660873	Length:	829	Species:	Mus musculus

Alignment Length:	981	Identity:	255/981 - (25%)
Similarity:	401/981 - (40%)	Gaps:	257/981 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 STWTKADITRMLKNVAMQSRIVI--MCADPQSIRQIMLTAE---ELNMIDSGE---YVFINIELF 330
            |.|....:   :::|.:...:|.  .|...:.:...:|.||   ::.|.|:.:   |..:..|..
Mouse     5 SCWVSLHV---IRSVCVCDEVVFTNTCLIERMVMSEVLCAEYTLKVKMSDTADGVLYEPLRAEFR 66

  Fly   331 S-----------RVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPN-DNEYTRVSNEIKA 383
            |           |.|:|.|     ...|....:|..|  |..:.:.|.... |..|..::..:::
Mouse    67 SKRTHLQGSAEGRGQFLAS-----LQSTSTAFQRFGK--TPGVQLRPGDTTLDTMYGFINTCLQS 124

  Fly   384 IAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALN-ESIRE-----DPTMLTRPINGTDMVRRM- 441
            :..||:.....:....||.|...|....:|.:.:. :.|:|     |.:|        :.:.::
Mouse   125 LVTEKFGEETWEKLKASAEVQDVFMTYTVYDDTITVKLIQEACKALDVSM--------EAILKLF 181

  Fly   442 ------------WNRSFTGITGNVT-IDANGDRLSAY---SLLDMNPTTGRFEIVAHFLHNRLEF 490
                        ::|....:.||:| ...|.|.|.:|   |..:||..:.|.|..|
Mouse   182 GEYFFKFCKMSGYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFRVEGGA--------- 237

  Fly   491 EANKEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGTMVVVMAVC-FFFGYRHYIA 554
            :....:|:..||      |.:|         :.:||            ::.||. .||.....::
Mouse   238 DGAMRLHYYSDR------RGLC---------HIVPG------------IIEAVAKDFFDTDVAMS 275

  Fly   555 EAEINSMSWKV-SLEDVMFR--DAAERGLRGSFHSLVKQSSQLTLMSEDMVSING------DRQI 610
            ..::|....:. ..|.|:|.  ..|.|.:||:..:..:.|..:....|   |:.|      :|.:
Mouse   276 ILDMNEEVERTGKKEHVVFLVVQKARRQIRGAKVNRPRDSENIQAKQE---SLQGTLLRKKERYL 337

  Fly   611 FIPVGMFRKSKVAIKPVEV--------DNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRR 667
            .|||....||..|:....|        |..|.:....|.:|.:...:....|:| |..|...::.
Mouse   338 SIPVCPGEKSHSAVVRASVLLGKGPLGDTFQPVFPERLWIEEEVFCNAFPFHVV-FDEALRVKQA 401

  Fly   668 SFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRF 732
            ...:.:|.| |.|     .::|.||..|  |::|..|.             .|:.|....::|:|
Mouse   402 GVNIQKYVP-GIL-----TQKFGLDEYF--SIVHPQVT-------------FNISSICKFINSQF 445

  Fly   733 VLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGII 797
            :||           ||.::..:.             |.:...|::........:.|..|:
Mouse   446 ILK-----------TRREMMPEA-------------WKSQPTLKLRGQMIWMESLKCMVF----- 481

  Fly   798 VHEITTRQGPFYLGRCAYE-KSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWA 861
                          .|:.: :|.||:.|          .|....::.|: ||..|:..:.::..|
Mouse   482 --------------MCSPKLRSLQELEE----------SKMHLSDIAPH-DTTRDLILLNQQRLA 521

  Fly   862 EDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEE-RTQDYH--EEKKKCE 923
            |                                  ||| :..||:..|| |....|  .||||.|
Mouse   522 E----------------------------------MEL-SCQLEKKKEELRVLSNHLAIEKKKTE 551

  Fly   924 KLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSI 988
            .|||.:||:.||.||..|:.|.|..|:..||.|||:|.||.|.|...|:|:|..||.:|:.||.:
Mouse   552 TLLYAMLPEHVANQLKEGKKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRL 616

  Fly   989 VENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHR------PEDRLK 1047
            ....|||||||||||||||.|:|: ....||:.:|..||.:       ||..:      ..:.::
Mouse   617 TNIHDVYKVETIGDAYMVVGGVPV-PVESHAQRVANFALGM-------RISAKEVMNPVTGEPIQ 673

  Fly  1048 LRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRR 1112
            :|:|:|||..:|||||.||||||||||||||||||||:|...|:|:|.|...||:..|..:.| |
Mouse   674 IRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAHRALENKGFEIVT-R 737

  Fly  1113 GFVPMKGKGEMLTYWL-------EGEVPRPNSLISPSKLMLTRRSSLKQPQRSQSHNLHKQYSEL 1170
            |.:.:||||:|.||:|       |.|:....|.::..|...|.|:.:|:|:...|:..|.|  :.
Mouse   738 GEIEVKGKGKMTTYFLIRNLNATEVEIMGRPSALADGKEASTPRNQVKKPRAVLSNMDHHQ--QQ 800

  Fly  1171 VVASPP 1176
            |..|.|
Mouse   801 VYNSDP 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	49/266 (18%)
		ANF_receptor	108..473	CDD:279440	46/241 (19%)
		PK_GC-A_B	589..883	CDD:270944	55/308 (18%)
		Pkinase_Tyr	613..877	CDD:285015	49/272 (18%)
		HNOBA	<893..938	CDD:285003	21/47 (45%)
		CYCc	917..1108	CDD:214485	98/196 (50%)
		Guanylate_cyc	944..1130	CDD:278633	94/198 (47%)
Gucy1b2	XP_011243363.2	HNOB	115..276	CDD:400167	37/204 (18%)
		HNOBA	380..566	CDD:400168	60/296 (20%)
		Guanylate_cyc	572..754	CDD:306677	93/190 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810