Protein Alignment CG31183 and Gucy1a2

DIOPT Version :10

• Sequence 1: NP_650505.2
• Gene: CG31183 / 41927
• FlyBaseID: FBgn0051183
• Length: 1417
• Species: Drosophila melanogaster
• Sequence 2: NP_001028494.1
• Gene: Gucy1a2 / 234889
• MGIID: 2660877
• Length: 730
• Species: Mus musculus
• Alignment Length: 685
• Identity: 192/685 - (28%)
• Similarity: 286/685 - (41%)
• Gaps: 179/685 - (26%)

  Fly   572 FRDAAERGLRGSFHSLVKQSSQLTLMSEDMVSINGDRQIFIPVGMFRKSKVAIKPVEVDNVQGLL 636
            :|||.:     :||::.|:.|.....:::                           |:::|.|:|
Mouse   121 YRDAEK-----NFHNISKRCSYADHSNKE---------------------------EIEDVSGIL 153

  Fly   637 TRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGS-LQDI----------------- 683
            ..:..:...:.:::|.....:|:..|.|:....|..    .|| |||.
Mouse   154 QCTANVLGLQFQEIQERFGEEFFKICFDENERVLRA----VGSTLQDFFNGFDALLEHIRTSFGK 214

  Fly   684 ---LENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSH--------GNLKSSNCVVDSRFVLKIT 737
               ||:..|         |..::..|...||.  ...|        |.:|::.        .:|.
Mouse   215 QATLESSSF---------LCKELPEGTLMLHY--FHPHHTVGFAMLGMIKAAG--------KRIY 260

  Fly   738 DFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEIT 802
            ...:...:.....|..||.|.::.:..:.|:.........:.|  |:||.:  |.|...|.....
Mouse   261 HLNVEVEQIENEKLCFDGSNPSNCSCLTFLIKECETTQITKDN--PQGTSQ--VPADLRISINTF 321

  Fly   803 TRQGPFYLGRCAYEKSPQEIIELVKG------YNPHRMQK------------------------- 836
            .|..||:|    ...|...:::|.:|      |:.||..|
Mouse   322 CRAFPFHL----MFDSNMVVLQLGEGLRKQLRYDTHRALKFEDCFEIVSPMINATFDRVLLRLST 382

  Fly   837 PF----RPELE--PNGDTKADINGIIRRCWAEDPA----ERPDFNTLKSMIRR-----------F 880
            ||    :||..  .|.|...:|.|.:... .|..|    ..|..:.|..::.|           .
Mouse   383 PFVIRTKPEASGTENEDKVMEIKGQMIHV-PESSAILFLGSPCVDKLDELMGRGLHLSDIPIHDA 446

  Fly   881 NKD----NETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISG 941
            .:|    .|.....|.|.|||:    .|:..:|...|...|||||...|||.:.|..||.||..|
Mouse   447 TRDVILVGEQAKAQDGLKKRMD----KLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQG 507

  Fly   942 QPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMV 1006
            |.|.|..||.||:.||||||||||.|:.|||||:..||:|||.||......|:||||||||||.|
Mouse   508 QQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGLLDIYKVETIGDAYCV 572

  Fly  1007 VSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDR-LKLRIGLHTGACVAGVVGLKMPRYC 1070
            .|||. |....||:.||.:||.::|......   .|:.: :::|||:|:|:.:|||||::|||||
Mouse   573 ASGLH-RKSLCHAKPIALMALKMMELSEEVL---TPDGKAIQMRIGIHSGSVLAGVVGVRMPRYC 633

  Fly  1071 LFGDTVNTASRMESNGEALKIHISETTKEAL---DEFGTFVTTRRGFVPMKGKGEM--LTYWLE- 1129
            |||:.|..||:.||.....:|::|.||.:.|   |.| ||:...|..:|.....|:  :.|:||
Mouse   634 LFGNNVTLASKFESGSHPRRINVSPTTYQLLKREDSF-TFIPRSREELPDNFPKEIPGVCYFLEL 697

  Fly  1130 ---GEVPRPNSLISPSKL---------MLTRRSSL 1152
               .:.|:|:  :|.|::         |..|.:||
Mouse   698 RTDPKPPKPS--LSSSRIKKVSYNIGTMFLRETSL 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_650505.2	PBP1_NPR-like	87..493	CDD:380596
		PK_GC-A_B	589..883	CDD:270944	63/374 (17%)
		HNOBA	<890..938	CDD:462234	19/47 (40%)
		CYCc	917..1108	CDD:214485	99/194 (51%)
Gucy1a2	NP_001028494.1	HNOB	<157..268	CDD:462233	21/133 (16%)
		HNOBA	314..501	CDD:462234	44/195 (23%)
		Guanylate_cyc	512..696	CDD:425528	88/188 (47%)