DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and PHLPP2

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_055835.2	Gene:	PHLPP2 / 23035	HGNCID:	29149	Length:	1323	Species:	Homo sapiens

Alignment Length:	1405	Identity:	252/1405 - (17%)
Similarity:	441/1405 - (31%)	Gaps:	490/1405 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 IHDTIEEHSVYQLGFDTSTWTKADITRMLKNVAMQSR--IVIMCA--DPQS-------------- 303
            :.:.::...||..|.||:|.|....|....:.:..|.  .:::|.  .|.|
Human    24 LREDVKRGCVYLYGADTTTATTTTTTSSSSSSSSSSSDLHLVLCTVETPASEICAGEGRESLYLQ 88

  Fly   304 -----IRQIMLTAEELNMIDSGEYVFI----------------NIELFSRVQYLTSQPWY-DKND 346
                 :|::..|...|.::    |.::                |.:|...:::...:|.: |:.|
Human    89 LHGDLVRRLEPTERPLQIV----YDYLSRLGFDDPVRIQEEATNPDLGCMIRFYGEKPCHMDRLD 149

  Fly   347 ----TDLNNERAQKAY-------------TAMLTVTPKQPNDNE---YTRVSNEIKAIAAEKYNY 391
                :.:.|.|..|..             |.::..:.|.....:   ...|..:|:.:...:|:.
Human   150 RILLSGIYNVRKGKTQLHKWAERLVVLCGTCLIVSSVKDCQTGKMHILPLVGGKIEEVKRRQYSL 214

  Fly   392 TFSD-NEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGN--V 453
            .||. ......:..||            |::.|               .:.|.|..:.:...  .
Human   215 AFSSAGAQAQTYHVSF------------ETLAE---------------YQRWQRQASKVVSQRIS 252

  Fly   454 TIDANGDRLSAYSLLDMNPTTGRFEIVAHFL-----------HNRLEFEANKEIHWAGDREEAPP 507
            |:|     ||.|||         .|:..|..           ||.::.|
Human   253 TVD-----LSCYSL---------EEVPEHLFYSQDITYLNLRHNFMQLE---------------- 287

  Fly   508 DRPICGYD---------GALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSW 563
             || .|.|         |.....|.|..:.||...:.|:..:...|..|    :...::|.::
Human   288 -RP-GGLDTLYKFSQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGF----HDLPSQIGNL-- 344

  Fly   564 KVSLEDVMFRDAAERGLRGSF-HSLVKQSSQLTLMSEDMVSINGDRQI---FIPVGMFRKSKVAI 624
             ::|:.:.        |.|:| .:|.::...|..:|...:|.|...||   :..:.|..:..:|.
Human   345 -LNLQTLC--------LDGNFLTTLPEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAG 400

  Fly   625 KPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQF 689
            ..:||.|: |:|.|  |..:|.: ||:.:||                     |..:.:.||..:
Human   401 NCLEVLNL-GVLNR--MNHIKHV-DLRMNHL---------------------KTMVIENLEGNK- 439

  Fly   690 QLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRR-------- 746
                    .:.|..:|..: |...|:.|..:|:..:|..:....|.::.|.|.||..
Human   440 --------HITHVDLRDNR-LTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAV 495

  Fly   747 ---------TRFDLESDGGNCNSHAYWSKLLWTAP----ELLRVEHNRPPEGTQKGDVYAFGIIV 798
                     |..||..:...|...       |...    |:|.|.:|                ::
Human   496 NVYPVPSLLTFLDLSRNLLECVPD-------WACEAKKIEVLDVSYN----------------LL 537

  Fly   799 HEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAED 863
            .|:..|    .|...:..|       |:.|:| |....|...|..|........|.:.|
Human   538 TEVPVR----ILSSLSLRK-------LMLGHN-HVQNLPTLVEHIPLEVLDLQHNALTR------ 584

  Fly   864 PAERPDFNTLKSMIRRFNKDNETGNIVDNL---------LKRMEL--YANNL------------- 904
               .||  ||.|........|.:.|.:::|         |..::|  ..|||
Human   585 ---LPD--TLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHL 644

  Fly   905 ----EELVEERTQDYHEEK-KKCEKL--------LYQLLPQSVAAQLISGQPVVAETFDQVTIYF 956
                ..|...:.|.:...| .|.|:|        ..:.:|.::|.         .:....:..:.
Human   645 HLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIAN---------CKRLHTLVAHS 700

  Fly   957 SDIVGFTAISAESTPMQVVQFL----NDLY-----TCFDSIVENFDVYKVETIGDAYMVVSGLPI 1012
            ::|    :|..|...:..:||:    |||.     ....:.:::.|:     .|:..:|:
Human   701 NNI----SIFPEILQLPQIQFVDLSCNDLTEILIPEALPATLQDLDL-----TGNTNLVL----- 751

  Fly  1013 RNGNQHAREIARLALALLEAVHNFRIHHRP----EDRLKLRIGLHTGACVAG------VVGLKMP 1067
                :|.      .|.:...:...:|..:|    :..:......|..|.:||      |..|.|.
Human   752 ----EHK------TLDIFSHITTLKIDQKPLPTTDSTVTSTFWSHGLAEMAGQRNKLCVSALAMD 806

  Fly  1068 R--------YCLF-GDTVNTASRME--SNGEALKIHISETTKEALDEFGTFVTTRR--GFVPMK- 1118
            .        |.:| ||......|:.  :..:.|...:.::|.:.:....||:.:.|  |....|
Human   807 SFAEGVGAVYGMFDGDRNEELPRLLQCTMADVLLEEVQQSTNDTVFMANTFLVSHRKLGMAGQKL 871

  Fly  1119 GKGEMLTYWLEGEVPRPNSLISPSKLMLT---------------------RRSSLKQ-PQRSQSH 1161
            |...:|.|      .||::....|...||                     :..||:| |:.:|.
Human   872 GSSALLCY------IRPDTADPASSFSLTVANVGTCQAVLCRGGKPVPLSKVFSLEQDPEEAQR- 929

  Fly  1162 NLHKQYSELVVASP------------------PPQLPPPAIALPPPPSPSKDSPNLRVKRKISSS 1208
              .|....::....                  |..||.|.|:..|          |.::.::...
Human   930 --VKDQKAIITEDNKVNGVTCCTRMLGCTYLYPWILPKPHISSTP----------LTIQDELLIL 982

  Fly  1209 SPKLNGGGFDYHKTEN---HYLDTAAAAQRNCDIYSSRSLRDMEETSDSWELAHFRLPLSGALKS 1270
            ..|.......|.:..|   |..|..|||::.|.:..|...:|.                .||:..
Human   983 GNKALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSYGCQDN----------------VGAMVV 1031

  Fly  1271 HHHLNNNSHGYVHSNSSSNLSGILQPPPLG-VQRTRLKPSPTISTLLTSA------RSEANASP- 1327
              :||....|     .:..::|:..|.|:| ...|.:|.:|..:|..:|:      .||.:.|.
Human  1032 --YLNIGEEG-----CTCEMNGLTLPGPVGFASTTTIKDAPKPATPSSSSGIASEFSSEMSTSEV 1089

  Fly  1328 GPETGSMGSGQLRIKFAEGDETPLLPTPPPLAA--PPPI-------PQMVAASPQRSGSGQNIPA 1383
            ..|.||..|.:..   |.|.:|.|||.|....:  |.|.       |.....|..:|.:|.:...
Human  1090 SSEVGSTASDEHN---AGGLDTALLPRPERRCSLHPTPTSGLFQRQPSSATFSSNQSDNGLDSDD 1151

  Fly  1384 DSSHYGFLVKSYK---------------QQCPPVAGSAVT 1408
            |....|.:....|               :..||:..|:.|
Human  1152 DQPVEGVITNGSKVEVEVDIHCCRGRDLENSPPLIESSPT 1191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	49/314 (16%)
		ANF_receptor	108..473	CDD:279440	44/278 (16%)
		PK_GC-A_B	589..883	CDD:270944	62/317 (20%)
		Pkinase_Tyr	613..877	CDD:285015	56/284 (20%)
		HNOBA	<893..938	CDD:285003	14/81 (17%)
		CYCc	917..1108	CDD:214485	36/229 (16%)
		Guanylate_cyc	944..1130	CDD:278633	37/218 (17%)
PHLPP2	NP_055835.2	PH_PHLPP-like	149..243	CDD:270131	17/120 (14%)
		LRR 1	250..271		9/34 (26%)
		leucine-rich repeat	253..273	CDD:275380	9/33 (27%)
		LRR 2	273..296		7/40 (18%)
		leucine-rich repeat	274..300	CDD:275380	7/43 (16%)
		LRR 3	300..321		5/20 (25%)
		leucine-rich repeat	301..323	CDD:275380	5/21 (24%)
		LRR_RI	313..606	CDD:238064	75/388 (19%)
		LRR_8	322..380	CDD:290566	13/72 (18%)
		LRR 4	323..344		4/24 (17%)
		leucine-rich repeat	324..346	CDD:275380	3/28 (11%)
		LRR 5	346..368		5/29 (17%)
		leucine-rich repeat	347..369	CDD:275380	6/29 (21%)
		LRR 6	369..390		5/20 (25%)
		leucine-rich repeat	370..416	CDD:275380	14/48 (29%)
		LRR 7	392..412		6/20 (30%)
		LRR 8	416..439		8/44 (18%)
		leucine-rich repeat	418..440	CDD:275380	8/52 (15%)
		LRR 9	440..460		5/20 (25%)
		leucine-rich repeat	442..461	CDD:275380	5/19 (26%)
		LRR 10	461..480		3/18 (17%)
		leucine-rich repeat	462..481	CDD:275380	3/18 (17%)
		LRR 11	481..502		3/20 (15%)
		leucine-rich repeat	482..503	CDD:275380	3/20 (15%)
		LRR 12	503..524		5/27 (19%)
		leucine-rich repeat	504..526	CDD:275380	5/28 (18%)
		LRR 13	526..547		7/40 (18%)
		leucine-rich repeat	527..549	CDD:275380	7/41 (17%)
		LRR_8	549..606	CDD:290566	17/75 (23%)
		LRR 14	549..570		7/28 (25%)
		leucine-rich repeat	550..565	CDD:275380	5/22 (23%)
		LRR 15	571..592		7/31 (23%)
		leucine-rich repeat	572..595	CDD:275380	7/33 (21%)
		LRR 16	595..616		3/20 (15%)
		leucine-rich repeat	596..645	CDD:275380	8/48 (17%)
		LRR 17	621..644		4/22 (18%)
		LRR_8	645..703	CDD:290566	8/66 (12%)
		LRR_4	645..685	CDD:289563	6/39 (15%)
		LRR 18	645..666		3/20 (15%)
		leucine-rich repeat	646..669	CDD:275380	4/22 (18%)
		LRR 19	669..690		3/29 (10%)
		leucine-rich repeat	670..692	CDD:275380	3/30 (10%)
		LRR 20	692..713		3/24 (13%)
		leucine-rich repeat	693..714	CDD:275380	3/24 (13%)
		LRR 21	714..735		5/20 (25%)
		leucine-rich repeat	715..734	CDD:275380	5/18 (28%)
		LRR 22	737..758		5/40 (13%)
		leucine-rich repeat	738..764	CDD:275380	5/45 (11%)
		PP2Cc	784..1033	CDD:238083	53/285 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1060..1157		25/99 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1285..1323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900