DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and Npr2

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_776149.1	Gene:	Npr2 / 230103	MGIID:	97372	Length:	1047	Species:	Mus musculus

Alignment Length:	1091	Identity:	479/1091 - (43%)
Similarity:	651/1091 - (59%)	Gaps:	101/1091 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 RQLVFVALLPSVESDNKNDCIMPKVLPVLELAIRHVQRMGFVGGSHFDIQLISR--DTFCSSKYG 146
            |.|....:||  |.:.......|:|.|.:.||:..:.|     ....|::.:|.  |..||....
Mouse    23 RNLTLAVVLP--EHNLSYAWAWPRVGPAVALAVEALGR-----ALPVDLRFVSSELDGACSEYLA 80

  Fly   147 PIGFFEIYTQWPEVNAVFGLPCEYVLAPISRYADVWQVPVLTTGGNAKEFNKKSESYSTLTRLKG 211
            |:...:: ..:.:.:.:.|..|.|..|.::|:|..|::|:||.|..|..|..|:|.|.||.| .|
Mouse    81 PLRAVDL-KLYHDPDLLLGPGCVYPAASVARFASHWRLPLLTAGAVASGFAAKNEHYRTLVR-TG 143

  Fly   212 AQVNNLGNVVRAILNSFNWT-RTALIYQNENAKVKGNSVCFLCLAAIHDTIE------EHSVYQL 269
            .....||..|..:...|||| |.||:|.:.....:.:   :..:..:.:.::      :|.||..
Mouse   144 PSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPH---YFTIEGVFEALQGSNLSVQHQVYAR 205

  Fly   270 ---GFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFS 331
               |.:.:|          ..:....|||.:|...:.:.:|:|.|:..| :.:|:|||..:::|.
Mouse   206 EPGGPEQAT----------HFIRANGRIVYICGPLEMLHEILLQAQREN-LTNGDYVFFYLDVFG 259

  Fly   332 R-----VQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNY 391
            .     ....|.:||.| |.|....:..::|:..:|.:|.::|.:.||....|.:...|.|.:..
Mouse   260 ESLRAGPTRATGRPWQD-NRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGV 323

  Fly   392 TFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTID 456
            ..:.: .::.....|:||:||||..|||:|:|..|.    .:|..:|.:|..|.:.|:||.|.:|
Mouse   324 ELAPS-LMNLIAGCFYDGILLYAQVLNETIQEGGTR----EDGLRIVEKMQGRRYHGVTGLVVMD 383

  Fly   457 ANGDRLSAYSLLDMNP-TTGRFEIVAHFLHNRLEFEANKEIHWAGDR----EEAPP-DRPICGY- 514
            .|.||.:.:.|..|.. .:|.|:..||:      ..|.|:|.|.|..    :.||| |.|.|.:
Mouse   384 KNNDRETDFVLWAMGDLDSGDFQPAAHY------SGAEKQIWWTGRPIPWVKGAPPLDNPPCAFD 442

  Fly   515 -DGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKVSLEDVMFRDAAER 578
             |...|....|...||:::..|...::..|..|..:|..:.|.|:.||.|::..|::.|.: ::|
Mouse   443 LDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGN-SDR 506

  Fly   579 GLRGSFHSLVKQSSQLTLMSE-----DMVSINGDRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTR 638
            ..:|:       .|:|||...     .:::.:|..|||...|.|:.:.||||.|....::  |||
Mouse   507 YHKGA-------GSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIE--LTR 562

  Fly   639 SLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDI 703
            .::.|||.|:|:|.:||.:|.|||:|.....::|||||:|||||||||:...||||||.||::|:
Mouse   563 QVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDL 627

  Fly   704 VRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLL 768
            |:||.|||:|.|.|||:||||||||||||||||||:||.:.|.|   .|.|    :|||.::|.|
Mouse   628 VKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRST---AEPD----DSHALYAKKL 685

  Fly   769 WTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVK-GYNPH 832
            |||||||. .:..|..|.||.|||:|.||:.||..|.|||||.  ..:.||:||::.|: |..|:
Mouse   686 WTAPELLS-GNPLPTTGMQKADVYSFAIILQEIALRSGPFYLE--GLDLSPKEIVQKVRNGQRPY 747

  Fly   833 RMQKPFRPELEPNGDTKADING----IIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNL 893
                 |||.::     :..:|.    ::.||||:||.|||||..:|..||||||:..| :|:|||
Mouse   748 -----FRPSID-----RTQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNL 801

  Fly   894 LKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSD 958
            |.|||.||||||:|||||||.|.|||:|.|.||||:||.|||.||..|:.|.||.||.|||||||
Mouse   802 LLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSD 866

  Fly   959 IVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIA 1023
            ||||||:||||||||||..|||||||||:|::|||||||||||||||||||||.|||.:||.|||
Mouse   867 IVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIA 931

  Fly  1024 RLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEA 1088
            |:|||||:||.:|||.|||.|:|:||||:|||...||||||||||||||||||||||||||||:|
Mouse   932 RMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQA 996

  Fly  1089 LKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGEVPRPNSLI 1139
            ||||:|.|||:||||.|.|....||.|.|||||:|.||||.||...|..|:
Mouse   997 LKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQKGPPGLL 1047

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	113/427 (26%)
		ANF_receptor	108..473	CDD:279440	102/382 (27%)
		PK_GC-A_B	589..883	CDD:270944	147/303 (49%)
		Pkinase_Tyr	613..877	CDD:285015	134/268 (50%)
		HNOBA	<893..938	CDD:285003	33/44 (75%)
		CYCc	917..1108	CDD:214485	149/190 (78%)
		Guanylate_cyc	944..1130	CDD:278633	146/185 (79%)
Npr2	NP_776149.1	PBP1_NPR_B	26..421	CDD:380607	113/429 (26%)
		PK_GC-A_B	518..792	CDD:270944	143/295 (48%)
		HNOBA	<798..846	CDD:369471	35/47 (74%)
		CYCc	825..1009	CDD:214485	144/183 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	295	1.000	Domainoid score	I1479
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2970
Inparanoid	1	1.050	809	1.000	Inparanoid score	I483
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	1	1.000	-	-		FOG0002376
OrthoInspector	1	1.000	-	-		otm42937
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5404
SonicParanoid	1	1.000	-	-		X2472
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760