DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and Adcy2

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_705762.2	Gene:	Adcy2 / 210044	MGIID:	99676	Length:	1095	Species:	Mus musculus

Alignment Length:	282	Identity:	86/282 - (30%)
Similarity:	142/282 - (50%)	Gaps:	41/282 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   893 LLKRMELYANNLEELVEERTQDYHEEKKKCEK----LLYQLLPQSVA----AQLISGQPVVAETF 949
            :|.|...|...|:.|.:.:.:...||.:..|.    ||..:||..||    |:.:..:.:..:::
Mouse   823 VLGRQSEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSY 887

  Fly   950 DQVTIYFSDIVGFTAISAES----TPMQVVQFLNDLYTCFDSIVEN---FDVYKVETIGDAYMVV 1007
            |.|.:.|:.|..|.....||    ..::.::.||::...||.::..   ..|.|::|||..||..
Mouse   888 DCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAA 952

  Fly  1008 SGLPIRNGNQHARE----------IARLALAL---LEAV--HNFRIHHRPEDRLKLRIGLHTGAC 1057
            :||......:||:|          :...|.||   |:|:  |:|       :..|||:|::.|..
Mouse   953 TGLSAVPSQEHAQEPERQYMHIGTMVEFAYALVGKLDAINKHSF-------NDFKLRVGINHGPV 1010

  Fly  1058 VAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGE 1122
            :|||:|.:.|:|.::|:|||.||||:|.|...||.::|.|...|...| :..|.||.:.:||||:
Mouse  1011 IAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLG-YTCTCRGIINVKGKGD 1074

  Fly  1123 MLTYWLEGEVPRPNSLISPSKL 1144
            :.||::..|:.|.   :|.|.|
Mouse  1075 LKTYFVNTEMSRS---LSQSNL 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944
		Pkinase_Tyr	613..877	CDD:285015
		HNOBA	<893..938	CDD:285003	15/52 (29%)
		CYCc	917..1108	CDD:214485	67/220 (30%)
		Guanylate_cyc	944..1130	CDD:278633	66/207 (32%)
Adcy2	NP_705762.2	AC_N	<37..264	CDD:292831
		CYCc	240..443	CDD:214485
		Guanylate_cyc	285..469	CDD:278633
		DUF1053	499..603	CDD:283888
		CYCc	852..1060	CDD:214485	65/215 (30%)
		Guanylate_cyc	882..1081	CDD:278633	66/206 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810