DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and gcy-37

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_500171.2	Gene:	gcy-37 / 191658	WormBaseID:	WBGene00001557	Length:	708	Species:	Caenorhabditis elegans

Alignment Length:	624	Identity:	143/624 - (22%)
Similarity:	259/624 - (41%)	Gaps:	164/624 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   551 HYIAEAEINSMSWKVSLEDVMFR--DAAERGLRGSFHS-----------LVKQSSQLTLMSED-- 600
            ||.    |:.:::|..::...|:  ...|.||:..:.|           ||::::: ||...|
Worm   105 HYF----IDQIAFKSEMKGPTFQCEPFGESGLKLHYFSFRQGLFPIVKGLVRKTAR-TLFEMDVK 164

  Fly   601 --MVSINGDRQIFIPVGMFRKSKVAIKPVE-----------------VDNVQGL-LTRSLMLELK 645
              |:..|.:|:   ..||......:::|.:                 .:|.... |:.::::.|:
Worm   165 VCMLERNQERR---KSGMVEHVIFSVEPDDNHRKGKRLFHKFRNTKTTENAPSFTLSSTILVGLR 226

  Fly   646 RMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFL 710
            ..|::...|:.......::....:||.||.        |||::     ..::|   |:   ||.:
Worm   227 DFKNIFPYHVCFNKQMIIEHIGIYLLREYG--------LENKK-----TLKVS---DL---MQLV 272

  Fly   711 HSSDIR-SHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPEL 774
            ..|||: ::.|:.|.                |:||                            .:
Worm   273 QPSDIQLTYKNVLSY----------------LNTL----------------------------FI 293

  Fly   775 LRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFR 839
            .:::|:......|:|...||          |.|..|                ||
Worm   294 FQLKHHSKRNEVQEGSSEAF----------QQPLVL----------------KG----------- 321

  Fly   840 PELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIV---DNLLKRMELYA 901
             |:.|..|.    |.||..|.......| |...||..|......:.|.::|   .:.:.:||| .
Worm   322 -EMMPINDG----NSIIFICSPHVTTVR-DILNLKLYISDMPMHDATRDLVMLNQSRICQMEL-N 379

  Fly   902 NNLEEL---VEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFT 963
            ..|||.   :::.|::...:|.:.::||::.:|..:|..|.:.:.|.|:.|...::.|:||..|.
Worm   380 KKLEETMKKMKKMTEELEVKKSQTDRLLFEFVPPVIAEALRAAKTVPAQEFSDCSVIFTDIPDFF 444

  Fly   964 AISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQ-HAREIARLAL 1027
            .||...:|.:::..:.||:..||.|:|....|||.::.|:|::|.|:|  |.|| |..:...|||
Worm   445 TISVNCSPTEIITVVTDLFHRFDRIIEKHKGYKVLSLMDSYLIVGGVP--NANQYHCEDSLNLAL 507

  Fly  1028 ALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIH 1092
            .||...... :..:.|..::||||:|.|..|||:|..:.||:|:.|:|||....:.|:....|:.
Worm   508 GLLFEAKQV-VVPKLERSVRLRIGVHCGPVVAGIVSQQKPRFCVLGNTVNVTKSICSHSSPGKVL 571

  Fly  1093 ISETTKEALDEF--GTFVTTRRGFVPMKGKGEMLTYWLE 1129
            :|...:..:.:.  ..||....|::.:: .|::||::||
Worm   572 VSNAVRTMVTKHLKSIFVFNANGYLELQ-SGKVLTHFLE 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944	55/316 (17%)
		Pkinase_Tyr	613..877	CDD:285015	48/282 (17%)
		HNOBA	<893..938	CDD:285003	12/47 (26%)
		CYCc	917..1108	CDD:214485	60/193 (31%)
		Guanylate_cyc	944..1130	CDD:278633	62/189 (33%)
gcy-37	NP_500171.2	HNOB	3..165	CDD:285002	14/64 (22%)
		HNOBA	223..419	CDD:285003	58/302 (19%)
		CYCc	400..577	CDD:214485	60/179 (34%)
		Nucleotidyl_cyc_III	425..609	CDD:299850	60/187 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810