DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and gcy-34

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_506319.1	Gene:	gcy-34 / 191656	WormBaseID:	WBGene00001554	Length:	686	Species:	Caenorhabditis elegans

Alignment Length:	493	Identity:	131/493 - (26%)
Similarity:	220/493 - (44%)	Gaps:	88/493 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   727 VVDSRFVLKITDFG----LHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRV-EHNRPPEGT 786
            ::|....:.:.||.    .|.:......|...|....:|.. ::||.....:||: |.|||....
Worm   219 IIDDNLKVSLQDFSRALPYHFVLDESCRLVQCGDELYNHIP-NELLQPGTPILRIFEINRPQIPL 282

  Fly   787 QKGDVYAFGIIVHEITTRQGPF---YLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDT 848
            ...::..|...|..:..:..|.   ::.....|:..||:             :....|:|.|..|
Worm   283 DFENICNFINAVFVLQVKTSPLRKKHMNAMTKEEREQEV-------------EAMEEEVESNELT 334

  Fly   849 KADINGIIRRCWAEDPAERPDFNTLKSMI-------------RRFNK-------DNETGNIVDNL 893
            :.        |..:...:....:|.|.:|             .:|..       .:.|.:::  |
Worm   335 QG--------CHLKLKGQMMMLSTKKHIIYLCSPYVTSINELMQFGMRLTAMPLHDATRDLI--L 389

  Fly   894 LKR---------MELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETF 949
            |.:         ::|.|||  |.:|..|.:...|::|.:.:|..:||:.:|.||:||:.:....:
Worm   390 LNQQRLSDVEVNLQLEANN--EQLETMTHELEVERQKTDSILKDMLPRKIAKQLLSGEHLEPCEY 452

  Fly   950 DQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRN 1014
             :.|:.|.|:..|..|.....|..:|:.||:::...|.||....||||||:.|:||.|||:|...
Worm   453 -EATVMFCDLPAFQQIIPVCQPKNIVKLLNEVFFKLDRIVVLRGVYKVETVSDSYMTVSGIPDYT 516

  Fly  1015 GNQHAREIARLALALLEAVHNFR--IHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVN 1077
             ::||..:..:||.::....:..  ::..|   ..||||||:|..:|||||.|||||||||:||.
Worm   517 -SEHAENMCHVALGMMWEARSVMDPVNKTP---FLLRIGLHSGTIIAGVVGTKMPRYCLFGETVT 577

  Fly  1078 TASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGEVPRP------- 1135
            .||:|||.|.|.||..|..|.....|.|.|..:.||.:.:||:|::.||:|...:.:.
Worm   578 LASQMESLGVAGKIQCSSWTYSKAMETGRFEFSPRGRINVKGRGDVETYFLMRSLKKSIWEITDH 642

  Fly  1136 ------NSL--ISPSKLMLTRRSSLK---QPQRSQSHN 1162
                  ||:  ....::.:....::|   .|:.:|:|:
Worm   643 ERDVNVNSIEGYEELEIFIENAQTVKHDGHPKANQNHS 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944	30/183 (16%)
		Pkinase_Tyr	613..877	CDD:285015	28/157 (18%)
		HNOBA	<893..938	CDD:285003	15/53 (28%)
		CYCc	917..1108	CDD:214485	76/192 (40%)
		Guanylate_cyc	944..1130	CDD:278633	75/187 (40%)
gcy-34	NP_506319.1	HNOB	3..167	CDD:285002
		HNOBA	224..441	CDD:285003	45/242 (19%)
		CYCc	421..609	CDD:214485	77/192 (40%)
		Guanylate_cyc	453..629	CDD:278633	74/179 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810