DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and gcy-27

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_001255957.2	Gene:	gcy-27 / 191654	WormBaseID:	WBGene00001550	Length:	616	Species:	Caenorhabditis elegans

Alignment Length:	606	Identity:	192/606 - (31%)
Similarity:	307/606 - (50%)	Gaps:	62/606 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   561 MSWKV---SLEDVMFRDAAERGLRGSFHSLVKQSSQLTLMSEDMV-----SINGDRQIFIPVGMF 617
            |:|||   ||:.::.::|..|..|...:...|..:. .|.|...|     .|...|..||   .|
Worm    33 MTWKVPKESLKIIVNKNADARMQRELENRTAKDEAN-ALTSRRRVFGSYALIGTQRAEFI---QF 93

  Fly   618 RKSKVAIKPVEVDNVQGLLTRSLMLE-LKRMKDLQHDHLVKFYGACL--DQRRSFLLTEYCPKGS 679
            |:    ||.:::.|..        |: |..:|.|:||:|..|||..|  |.....:|.....:|:
Worm    94 RQ----IKHIDITNAS--------LDFLYNLKQLKHDNLANFYGIQLNDDLNTMTILHALVERGT 146

  Fly   680 LQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTL 744
            |::...:..|.:|..|:.:.|.||::|:|:||.|.:..||:|.::.|::|..:||||..:|:...
Worm   147 LEEFCLDRDFGMDETFKSAFMRDILKGLQYLHLSPVAYHGHLHAATCLIDINWVLKIALYGVTNF 211

  Fly   745 RRTRFDLE-------SDGGNCNSHAY---WSKLLWTAPELLRVEHN-------RPPEGTQKGDVY 792
            ....||.|       ||        |   :::.:...||.:| |::       |...|:::||:|
Worm   212 VCDNFDAENITMPDRSD--------YTISYAQYVCFPPEHIR-EYDATGKLPTRFVRGSKQGDIY 267

  Fly   793 AFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIR 857
            ..|:|.:.:..|:.|:.|...........::|::    .|.:. ||....|...||..|   ..:
Worm   268 CVGMIFYMMIEREDPYRLIHSVERPGSGLMMEIL----DHNLM-PFISNNETQEDTLLD---KCK 324

  Fly   858 RCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKC 922
            .||..||.:||....|::.|.....|:: ||::|.:::..|.||:.||.||..|:.|....:.:.
Worm   325 ECWNRDPEKRPTIENLRNAIAICYADSK-GNLIDQMIRMNEKYADELETLVAARSADLALAQMQT 388

  Fly   923 EKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDS 987
            .:||.::||.|:|..|.:|....|.::...|:.|..|..|..|.....|.:|:.||||::..||:
Worm   389 MRLLNEMLPASIAKDLKNGVIAPARSYASATVMFVQICDFIVILKRRPPKEVIGFLNDIFDQFDT 453

  Fly   988 IVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGL 1052
            :::..|.|||||.|:.|||.||:|..|..:|..|:|.::|.:.....::.:.:....:|::|||.
Worm   454 VIKRHDAYKVETTGETYMVASGVPNENEGRHVFEVAEMSLEIRAISLSYTLENDKNYKLRVRIGF 518

  Fly  1053 HTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPM 1117
            |.|...|||:|:|.|||||||||||.||||:||...|:|..||.|...|.....:...:||.|.:
Worm   519 HAGPIAAGVIGIKNPRYCLFGDTVNFASRMQSNCPPLQIQTSEITARMLLATHEYKLVKRGIVHV 583

  Fly  1118 KGKGEMLTYWLEGEVPRPNSL 1138
            |||||:..|||...:.:...:
Worm   584 KGKGEVNCYWLNEHIHKDEEI 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944	85/318 (27%)
		Pkinase_Tyr	613..877	CDD:285015	76/283 (27%)
		HNOBA	<893..938	CDD:285003	15/44 (34%)
		CYCc	917..1108	CDD:214485	74/190 (39%)
		Guanylate_cyc	944..1130	CDD:278633	77/185 (42%)
gcy-27	NP_001255957.2	PKc_like	75..338	CDD:304357	80/294 (27%)
		CYCc	383..573	CDD:214485	74/189 (39%)
		Guanylate_cyc	411..595	CDD:278633	76/183 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920