DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and gcy-19

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_001348702.1	Gene:	gcy-19 / 191650	WormBaseID:	WBGene00001544	Length:	1187	Species:	Caenorhabditis elegans

Alignment Length:	1243	Identity:	369/1243 - (29%)
Similarity:	573/1243 - (46%)	Gaps:	191/1243 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 PMPDHRRLGARRQLVFVALLPSVESDNKNDCIMPKVLPVLELAIRHVQRMGFVGGSHFDIQLISR 137
            |:|...|...|   |.||.:.:.|.|:..   .|.....:.:||:.::..||:  :.||.::...
Worm    35 PVPAANRRTIR---VGVAAVQTTELDSIG---WPMSGGAINMAIQKLRDDGFI--APFDFEVTVN 91

  Fly   138 DTFCSSKYGPIGFFEIYTQWPEVNAVFGLPCEYVLAPISRYADVWQVPVLTTGGNAKEFNKKSES 202
            .|.|....|.....| :.:...::.|.|.||...:..::..|..:..|:|..|.........:|.
Worm    92 YTECDRSLGAAVGME-FMRTKRLDVVIGPPCRDPMEIMATMATYYSTPMLGWGLVTDSKFTDTER 155

  Fly   203 YSTLTRLKGAQVNNLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLCLAAI--HDTIEEHS 265
            |..||.:. |...:||..:..:|....|.|.||:|: |:|:....||......||  :||...:.
Worm   156 YPYLTNIM-ANSLSLGFSLVKLLEMMEWDRVALVYE-ESAQDYPLSVINDVETAINEYDTFAVNV 218

  Fly   266 VYQLGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEE-LNMID-----SGEYVF 324
            |.:..........|....:|..:.::.||::      |:.|...|... |.|||     :.|||.
Worm   219 VVKQALPGGDLNDAQYISVLNRIKLRCRIIV------SVFQTAPTRRRYLKMIDQQGMANEEYVH 277

  Fly   325 INIELFS-------------RVQYLTS--QPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEY 374
            |.:.|.|             .:..|:|  .|::|....|..|:|.::|.|.||.:......|
Worm   278 ILLGLRSIGFGKQSAGLTKCELNCLSSGLAPFWDIAPDDGLNDRLKQAATRMLVMDLPDTMD--- 339

  Fly   375 TRVSNEIKAIAAEKYNYTFSDN----------------------EPISAFVTSFFDGVLLYANAL 417
              :|.::..|   .|..||:.|                      .|.|||..|..|...||..|:
Worm   340 --LSTDVPDI---NYLNTFTMNCGAVVVNPPVSCATPACINASTSPPSAFARSLHDVFYLYGLAI 399

  Fly   418 NESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAH 482
            .....:||..|    |..|.:......:|.|:||.|:|:||..|:....|..:|....:    |.
Worm   400 TNLYNQDPAYL----NDIDKINGALQLNFAGLTGEVSINANNSRVPKLMLYALNDKYDQ----AS 456

  Fly   483 FLHNRLEFEANKEI-----------HWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGT 536
            |::..........:           :|.|.:.  |...|:||:.|..||.:.:..|..|...:|.
Worm   457 FMNLTYSLNGGASVSLAYTNEASLWYWYGGKR--PLSVPVCGFAGTDCPQSFVDQYGALVFAIGG 519

  Fly   537 MVV----VMAVCFFFGYRHYIAEAEINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQSSQLTLM 597
            :::    .:..|||:..|....|.:.....|::.|..:......::. |.|..||....|.:|
Worm   520 VLIFAMLFVITCFFYVMRQKRLERDRIDAEWQIPLVKLQAPPKRDKE-RMSKRSLQSGPSNIT-- 581

  Fly   598 SEDMVSINGDRQIFIPVGMFRKSKVAIKPV-EVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGA 661
              |...:..| ..|....:|...|   :|| ...:....|.|:......|::.|.|:::.||.|.
Worm   582 --DTSKMTFD-NTFSNYSIFYLDK---EPVLSTAHPASNLIRTDYDTFVRLRKLDHENVNKFVGM 640

  Fly   662 CLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNC 726
            .:|......:.:.|.:||||||:....|.:|..|...::.|:..|:::||:|.:..|.||:|...
Worm   641 SIDGPEYLAVWKLCMRGSLQDIIGQGNFSIDPFFMFCVIRDMAEGLKYLHNSFLHVHANLRSGTV 705

  Fly   727 VVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGT----- 786
            :|:..:..|:|||||.||...:..::            .:.||.|||::|        ||
Worm   706 LVNESWQAKLTDFGLGTLAEEKKPMK------------RRQLWMAPEVIR--------GTLLPHQ 750

  Fly   787 --QKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTK 849
              :..|:|:..:|..|:.||:..:.:..  .:.:..||:..:|...|:..    ||||:.:|
Worm   751 IEKSADIYSLAVIASEVLTRKEAWNMAE--RKDTVDEIVYRIKKGGPNAP----RPELDMDG--- 806

  Fly   850 ADING----IIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEE 910
            .:||.    :||.||:|:||:||..:.:.::::  |...:.||::|::...:|.|..|||..||:
Worm   807 VEINHNLLILIRDCWSEEPADRPSADVICNLLK--NMMPKKGNLMDHVFNILEDYTTNLEVEVED 869

  Fly   911 RTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVV 975
            ||::...||||.:.||.::||:.||.:|..||.|..|.||.||::|||:|.||.::|:.:|.|||
Worm   870 RTKELTAEKKKADVLLGRMLPKQVAERLKQGQTVEPEGFDSVTVFFSDVVKFTQLAAKCSPFQVV 934

  Fly   976 QFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHH 1040
            ..|||||:.||:|:|....||||:|||.|:.|||||.:|||.|.::|..|:|..:....:|:|.|
Worm   935 NLLNDLYSNFDAIIEEHGCYKVESIGDGYLCVSGLPSKNGNAHIKQIVELSLDFMSYCKSFKIPH 999

  Fly  1041 RPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEF- 1104
            .|.::::||||:::|.||||||||.|||||||||||||||||||||:|..||:|..:...|.:.
Worm  1000 LPREKVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKASHIHLSAASYTLLMKHY 1064

  Fly  1105 -GTFVTTRRGFVPMKGKGEMLTYWLEGEVPRPNSLISPSKLMLTRRSSLKQPQRSQSHNLHKQYS 1168
             ..:.|..||.|.:||||.|.|:|:   ..|.|..:..|.      :|..|..:..::|
Worm  1065 PNQYNTASRGDVIIKGKGVMETFWV---FERNNQFMGVSS------NSGYQSDKKATNN------ 1114

  Fly  1169 ELVVASPPPQLPPPAIALPP--------------PPSPSKDSPNLRVKRKISSSSPKLNGGGFDY 1219
                .|.|...||   :.||              |||||  ||.|. ||.:   ||.:.....|.
Worm  1115 ----GSSPESTPP---STPPMHEVKANSPVRHRKPPSPS--SPTLS-KRSV---SPIMEAKARDI 1166

  Fly  1220 HKTENHYL 1227
            |..|...|
Worm  1167 HNEETEAL 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	107/465 (23%)
		ANF_receptor	108..473	CDD:279440	100/409 (24%)
		PK_GC-A_B	589..883	CDD:270944	81/305 (27%)
		Pkinase_Tyr	613..877	CDD:285015	75/275 (27%)
		HNOBA	<893..938	CDD:285003	19/44 (43%)
		CYCc	917..1108	CDD:214485	102/192 (53%)
		Guanylate_cyc	944..1130	CDD:278633	100/187 (53%)
gcy-19	NP_001348702.1	PBP1_NPR_GC_like	45..467	CDD:107347	109/454 (24%)
		PKc_like	571..841	CDD:328722	82/308 (27%)
		CYCc	876..1065	CDD:214485	102/188 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7809
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910