Protein Alignment CG31183 and gcy-19

DIOPT Version :10

• Sequence 1: NP_650505.2
• Gene: CG31183 / 41927
• FlyBaseID: FBgn0051183
• Length: 1417
• Species: Drosophila melanogaster
• Sequence 2: NP_001348702.1
• Gene: gcy-19 / 191650
• WormBaseID: WBGene00001544
• Length: 1187
• Species: Caenorhabditis elegans
• Alignment Length: 1243
• Identity: 369/1243 - (29%)
• Similarity: 573/1243 - (46%)
• Gaps: 191/1243 - (15%)

  Fly    73 PMPDHRRLGARRQLVFVALLPSVESDNKNDCIMPKVLPVLELAIRHVQRMGFVGGSHFDIQLISR 137
            |:|...|...|   |.||.:.:.|.|:..   .|.....:.:||:.::..||:  :.||.::...
 Worm    35 PVPAANRRTIR---VGVAAVQTTELDSIG---WPMSGGAINMAIQKLRDDGFI--APFDFEVTVN 91

  Fly   138 DTFCSSKYGPIGFFEIYTQWPEVNAVFGLPCEYVLAPISRYADVWQVPVLTTGGNAKEFNKKSES 202
            .|.|....|.....| :.:...::.|.|.||...:..::..|..:..|:|..|.........:|.
 Worm    92 YTECDRSLGAAVGME-FMRTKRLDVVIGPPCRDPMEIMATMATYYSTPMLGWGLVTDSKFTDTER 155

  Fly   203 YSTLTRLKGAQVNNLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLCLAAI--HDTIEEHS 265
            |..||.:. |...:||..:..:|....|.|.||:|: |:|:....||......||  :||...:.
 Worm   156 YPYLTNIM-ANSLSLGFSLVKLLEMMEWDRVALVYE-ESAQDYPLSVINDVETAINEYDTFAVNV 218

  Fly   266 VYQLGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEE-LNMID-----SGEYVF 324
            |.:..........|....:|..:.::.||::      |:.|...|... |.|||     :.|||.
 Worm   219 VVKQALPGGDLNDAQYISVLNRIKLRCRIIV------SVFQTAPTRRRYLKMIDQQGMANEEYVH 277

  Fly   325 INIELFS-------------RVQYLTS--QPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEY 374
            |.:.|.|             .:..|:|  .|::|....|..|:|.::|.|.||.:......|
 Worm   278 ILLGLRSIGFGKQSAGLTKCELNCLSSGLAPFWDIAPDDGLNDRLKQAATRMLVMDLPDTMD--- 339

  Fly   375 TRVSNEIKAIAAEKYNYTFSDN----------------------EPISAFVTSFFDGVLLYANAL 417
              :|.::..|   .|..||:.|                      .|.|||..|..|...||..|:
 Worm   340 --LSTDVPDI---NYLNTFTMNCGAVVVNPPVSCATPACINASTSPPSAFARSLHDVFYLYGLAI 399

  Fly   418 NESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAH 482
            .....:||..|    |..|.:......:|.|:||.|:|:||..|:....|..:|....:    |.
 Worm   400 TNLYNQDPAYL----NDIDKINGALQLNFAGLTGEVSINANNSRVPKLMLYALNDKYDQ----AS 456

  Fly   483 FLHNRLEFEANKEI-----------HWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGT 536
            |::..........:           :|.|.:.  |...|:||:.|..||.:.:..|..|...:|.
 Worm   457 FMNLTYSLNGGASVSLAYTNEASLWYWYGGKR--PLSVPVCGFAGTDCPQSFVDQYGALVFAIGG 519

  Fly   537 MVV----VMAVCFFFGYRHYIAEAEINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQSSQLTLM 597
            :::    .:..|||:..|....|.:.....|::.|..:......::. |.|..||....|.:|
 Worm   520 VLIFAMLFVITCFFYVMRQKRLERDRIDAEWQIPLVKLQAPPKRDKE-RMSKRSLQSGPSNIT-- 581

  Fly   598 SEDMVSINGDRQIFIPVGMFRKSKVAIKPV-EVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGA 661
              |...:..| ..|....:|...|   :|| ...:....|.|:......|::.|.|:::.||.|.
 Worm   582 --DTSKMTFD-NTFSNYSIFYLDK---EPVLSTAHPASNLIRTDYDTFVRLRKLDHENVNKFVGM 640

  Fly   662 CLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNC 726
            .:|......:.:.|.:||||||:....|.:|..|...::.|:..|:::||:|.:..|.||:|...
 Worm   641 SIDGPEYLAVWKLCMRGSLQDIIGQGNFSIDPFFMFCVIRDMAEGLKYLHNSFLHVHANLRSGTV 705

  Fly   727 VVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGT----- 786
            :|:..:..|:|||||.||...:..::            .:.||.|||::|        ||
 Worm   706 LVNESWQAKLTDFGLGTLAEEKKPMK------------RRQLWMAPEVIR--------GTLLPHQ 750

  Fly   787 --QKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTK 849
              :..|:|:..:|..|:.||:..:.:..  .:.:..||:..:|...|:..    ||||:.:|
 Worm   751 IEKSADIYSLAVIASEVLTRKEAWNMAE--RKDTVDEIVYRIKKGGPNAP----RPELDMDG--- 806

  Fly   850 ADING----IIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEE 910
            .:||.    :||.||:|:||:||..:.:.::::  |...:.||::|::...:|.|..|||..||:
 Worm   807 VEINHNLLILIRDCWSEEPADRPSADVICNLLK--NMMPKKGNLMDHVFNILEDYTTNLEVEVED 869

  Fly   911 RTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVV 975
            ||::...||||.:.||.::||:.||.:|..||.|..|.||.||::|||:|.||.::|:.:|.|||
 Worm   870 RTKELTAEKKKADVLLGRMLPKQVAERLKQGQTVEPEGFDSVTVFFSDVVKFTQLAAKCSPFQVV 934

  Fly   976 QFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHH 1040
            ..|||||:.||:|:|....||||:|||.|:.|||||.:|||.|.::|..|:|..:....:|:|.|
 Worm   935 NLLNDLYSNFDAIIEEHGCYKVESIGDGYLCVSGLPSKNGNAHIKQIVELSLDFMSYCKSFKIPH 999

  Fly  1041 RPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEF- 1104
            .|.::::||||:::|.||||||||.|||||||||||||||||||||:|..||:|..:...|.:.
 Worm  1000 LPREKVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKASHIHLSAASYTLLMKHY 1064

  Fly  1105 -GTFVTTRRGFVPMKGKGEMLTYWLEGEVPRPNSLISPSKLMLTRRSSLKQPQRSQSHNLHKQYS 1168
             ..:.|..||.|.:||||.|.|:|:   ..|.|..:..|.      :|..|..:..::|
 Worm  1065 PNQYNTASRGDVIIKGKGVMETFWV---FERNNQFMGVSS------NSGYQSDKKATNN------ 1114

  Fly  1169 ELVVASPPPQLPPPAIALPP--------------PPSPSKDSPNLRVKRKISSSSPKLNGGGFDY 1219
                .|.|...||   :.||              |||||  ||.|. ||.:   ||.:.....|.
 Worm  1115 ----GSSPESTPP---STPPMHEVKANSPVRHRKPPSPS--SPTLS-KRSV---SPIMEAKARDI 1166

  Fly  1220 HKTENHYL 1227
            |..|...|
 Worm  1167 HNEETEAL 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_650505.2	PBP1_NPR-like	87..493	CDD:380596	108/450 (24%)
		PK_GC-A_B	589..883	CDD:270944	81/305 (27%)
		HNOBA	<890..938	CDD:462234	20/47 (43%)
		CYCc	917..1108	CDD:214485	102/192 (53%)
gcy-19	NP_001348702.1	PBP1_NPR_GC-like	45..466	CDD:380575	109/453 (24%)
		Protein Kinases, catalytic domain	571..841	CDD:473864	82/308 (27%)
		CYCc	876..1065	CDD:214485	102/188 (54%)