DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and gcy-14

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_506660.2	Gene:	gcy-14 / 191647	WormBaseID:	WBGene00001540	Length:	1111	Species:	Caenorhabditis elegans

Alignment Length:	1093	Identity:	376/1093 - (34%)
Similarity:	550/1093 - (50%)	Gaps:	146/1093 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 GFVGGSHFDIQLISRDTFCSSKYGPIGFFEIYTQWPEVNAVFGLPCEYVLAPISRYADVWQVPV- 186
            |..||.  .::||:.|                    .|:.:.|..|......::..|..:.|||
Worm    76 GLAGGK--TVELINHD--------------------NVDVIIGPTCNRAGIAVASLAAYYNVPVF 118

  Fly   187 ---LTTGGNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTALIYQNENAKVKGNS 248
               |||   |.:....|...:|:|.........||  ||.:|..|.|.....||.|:..:.|
Worm   119 QWGLTT---AADIGNVSRYPTTVTLSLDTHSMALG--VREVLRRFEWDEFVFIYSNDGDEEK--- 175

  Fly   249 VCFLCLAAIHDTIE----EHSVYQLGF--DTSTWTKADITRMLKNVAMQSRIVIMC-ADPQSIRQ 306
                | |::.|.:|    |:|...|.:  ...|.|...:.:.|..|:.:.||:|.| |:.:..::
Worm   176 ----C-ASMKDDLEKMGIENSDVTLAYMVQIQTVTLDALQKALTEVSKRGRIIIACFANGRGFKK 235

  Fly   307 IMLTAEELNMIDSGEYVFINIELFSR---VQYLTSQPWYDKNDTD------LNNERAQKAYTAML 362
            ..:.:..|..:.:.||:::..|..||   |..:.....|..:|||      |..|:.:.||..:|
Worm   236 AFVASTVLAGMSTDEYMYMFAEPQSRGFYVDEINGGEHYSWDDTDGNFVTGLTPEQIRDAYGKVL 300

  Fly   363 ----------TVTPKQPNDNEYTRVSNE-IKAIAAEKYN----YTFSDNEPISAFVTSFFDGVLL 412
                      |:||      |:...|:: |..:..:.:|    .:.|..:..:.:....||....
Worm   301 YICDNMGLPTTITP------EFANFSSQLISRMTEQPFNCVQDCSNSTYKVPATYAGQLFDAFYA 359

  Fly   413 YANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGI-TGNVTIDANGDRLSAYSLLDMNPTTGR 476
            |..|||.|:.:|||..... ||:.::..: ..||.|: .|.||:|..|.|:....:..:|.:...
Worm   360 YGVALNRSLTQDPTRANLK-NGSFVLSDI-GMSFQGVGGGTVTLDDTGTRIVQVYMFALNTSLLP 422

  Fly   477 FEIVAHFLHNRLEFEANKEIHWAGDREEAPP-DRPICGYDGALCPDNSLPGYAILSIVLGTMVV- 539
            : :.|..:.|..|.|.........|.....| .|||||:.|..||.:.:..|.:.:|:...:||
Worm   423 Y-LAASLVINGSEVEYTPFYKSEADLWSVRPLARPICGFSGLECPPDFVKEYLVYTIIAAVIVVL 486

  Fly   540 -VMAVCFFFGYRHYI--AEAEINSMSWKV---SLEDVMFRDAAERGLRGSFHSLVKQSSQLTLMS 598
             ::|.|....|...:  .|.|...:.|:|   .|:.|..:..||..:. ||.|....|:::|:.|
Worm   487 ALLAGCAGLLYTMQMKRKEMERQDLLWQVPFIELQQVQSKSKAEASMH-SFASGPSTSTKITVES 550

  Fly   599 EDMVSINGDRQIFIPVGMFRKSKVAIKP---VEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYG 660
            .. .:||     ||.....:....|:|.   ::.|..|       ..|.::|::..:|:|.||.|
Worm   551 RS-ETIN-----FIFYYYQQDILAAMKHDLILQFDAEQ-------KAEFRQMRNFDNDNLNKFIG 602

  Fly   661 ACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSN 725
            .|||..:.|.|..:|.:|||.|::.....|:|..|..||:.||..|:.|:|:|.::.||:|.|..
Worm   603 LCLDGPQLFSLWRFCSRGSLSDVISKSSMQMDSFFMFSLIRDISNGLLFIHNSFLKCHGHLTSRC 667

  Fly   726 CVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEH-NRPPEGTQKG 789
            |::|.|:.:||:.:||.::|......:.|            ||||.||.||.|: .|.||    |
Worm   668 CLIDDRWQIKISGYGLKSVRTFENPKKED------------LLWTPPENLRNENEERLPE----G 716

  Fly   790 DVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVK--GYNPHRMQKPFRPELEPNGDTKADI 852
            |:|:||||..||.||...|.|..  .::.|..||..||  |:|      |.||.|: .|:| .:|
Worm   717 DIYSFGIICSEILTRSSAFDLEN--RKEKPDVIIYQVKKGGHN------PMRPSLD-TGET-VEI 771

  Fly   853 N----GIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQ 913
            |    .:||.||.|.|:|||....::..:... :|....|::|::...:|.||:.|||.|.:||:
Worm   772 NPALLHLIRDCWTERPSERPSIEQVRGHLNGM-RDGRKSNLMDHVFNMLETYASTLEEEVSDRTK 835

  Fly   914 DYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFL 978
            :..|||||.:.|||::||:.||.:|..||.|..|||:||||:|||:|.||.::.:.||:|||..|
Worm   836 ELVEEKKKSDVLLYRMLPKMVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLAGKCTPLQVVTLL 900

  Fly   979 NDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPE 1043
            |||||.||.|:|..||||||||||.|:.|||||.||||:|.|.|||::|..|.::..||:.|.|.
Worm   901 NDLYTIFDGIIEQNDVYKVETIGDGYLCVSGLPHRNGNEHIRHIARMSLGFLSSLEFFRVQHLPS 965

  Fly  1044 DRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDE-FGTF 1107
            :|:.||||::.|:.|||||||.|||||||||.|||||||||||:..|||::....:.|.: .|.|
Worm   966 ERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGKIHVTAEANQMLTQVVGGF 1030

  Fly  1108 VTTRRGFVPMKGKGEMLTYWLEGEVPRPNSLISPSKLMLTRRSSLKQPQRSQS 1160
            .|..||.|.:||||.|.||||.||    .|.||.|  ....|....:|.|.||
Worm  1031 RTESRGEVIIKGKGVMETYWLLGE----QSRISVS--AQAPREKTPEPPRRQS 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	97/410 (24%)
		ANF_receptor	108..473	CDD:279440	93/385 (24%)
		PK_GC-A_B	589..883	CDD:270944	101/303 (33%)
		Pkinase_Tyr	613..877	CDD:285015	94/273 (34%)
		HNOBA	<893..938	CDD:285003	21/44 (48%)
		CYCc	917..1108	CDD:214485	113/191 (59%)
		Guanylate_cyc	944..1130	CDD:278633	112/186 (60%)
gcy-14	NP_506660.2	PBP1_NPR_GC_like	21..423	CDD:107347	93/389 (24%)
		ANF_receptor	43..418	CDD:279440	92/384 (24%)
		PKc_like	535..800	CDD:304357	104/303 (34%)
		HNOBA	<817..860	CDD:285003	21/42 (50%)
		CYCc	839..1031	CDD:214485	113/191 (59%)
		Guanylate_cyc	866..1053	CDD:278633	112/186 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7809
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910