DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and gcy-9

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_509897.3	Gene:	gcy-9 / 191645	WormBaseID:	WBGene00001536	Length:	1081	Species:	Caenorhabditis elegans

Alignment Length:	1167	Identity:	347/1167 - (29%)
Similarity:	538/1167 - (46%)	Gaps:	171/1167 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 AESVGGVASIGVGSDEHSFKTPETKNSHKSQSTELVQHF-PSLPMPDHRRLGARRQLVFVALLPS 94
            |||...::.|     .|.......|.:..|:....:.|. |:.|:..|.              |.
Worm    14 AESRRSISKI-----SHDEINQHVKTTLSSEGIVRIGHLHPTNPIIAHE--------------PD 59

  Fly    95 VESDNKNDCIMPKVLPVLELAIRHVQRMGFVGGSHFDIQLISRDTFCSSKYGPIGFFEIYTQWPE 159
            |.....:|..|..:||                 .::.:.:.:.:: | :||..:...........
Worm    60 VLKMCADDLKMRNILP-----------------QNYTLTVFTMES-C-NKYSGVEHAAFLHYLKN 105

  Fly   160 VNAVFGLPCEYVLAPISRYADVWQVPVLT--TGGNAKEFNKKSESYSTLTRLKGAQVNNLGNVVR 222
            .:..||..|...:..|.|.|..|.||::.  :|.:|.   .....:.||..:.....:.:.....
Worm   106 ASVYFGPGCNNEMLVIGRLAPRWNVPIIAHMSGDDAL---SDRVQFPTLGSVALTSASEMAKATV 167

  Fly   223 AILNSFNWTRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTWTKADI------ 281
            ..||..||.:..::..         ||.:          |..|||.|.....   |.||
Worm   168 TYLNLNNWDQIGIVRP---------SVGY----------ERLSVYSLQHQIK---KRDINLNVIL 210

  Fly   282 -------------TRMLKNVAMQSRIVI--MCADPQSIRQIMLTAEELNMIDSGEYVFINIELFS 331
                         |..|..:...:||::  :..|..|:...|| |...:.|.:.|:||:
Worm   211 DIEPFSSPEEIISTGKLTTLKSMARIIVVELGMDIHSVTNFML-AIHRSEIKNEEFVFV------ 268

  Fly   332 RVQYLTSQ----PWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNY- 391
             :.:|..|    ||...|   ::.:..:.|:...:.:|....:...:.....:..|:.....|:
Worm   269 -IPWLAHQNDHYPWEAAN---VDKQEVKLAFENTIIITAHGYDKKFFDDFQMKFSAVTGVLANHY 329

  Fly   392 -TFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTI 455
             |.|        ..|.:|.:.||..||.::. ||.......:||:.:..||.||.|.|:||.|.:
Worm   330 ATLS--------YMSLYDALFLYGLALRDAF-EDGGGYNVHMNGSLIWSRMTNRQFIGMTGQVLM 385

  Fly   456 DANGDRLSAYSLLDMNPTTGRFEIVAHF---LHNRLEFEANKEI------------HWAGDREEA 505
            :....|:.:|:  ..:...|..:||...   .::|.:.|.|:|:            :|..|..:.
Worm   386 NNKAIRVPSYA--TYHAINGTLKIVVELEAKNNDRGQCEKNEEMCSEHVAHETIQYYWPSDSGKL 448

  Fly   506 PPDRPICGYDGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAE--INSMSWKVSLE 568
            ||..|.||:.||.|   ....|.|.:.:|..::.|..:.:|.    |:.:.|  :..|:|::..|
Worm   449 PPAVPKCGFTGAEC---DYRPYFIGASLLAFILTVGPLSYFI----YLKQKERLLYDMTWRIPRE 506

  Fly   569 DVMFRDAAERGLRGSFHSLVKQSSQLTLMSEDMVS-INGDRQIFIPVGMFRKSKVAIKPV-EVDN 631
            .:...:    |...|.|||..:|......|..|.| .||  .|.....:....|:|||.. :|.|
Worm   507 SIKMLE----GKSKSEHSLASKSQSSGSFSGSMNSKQNG--LIAAKQAVSNGVKLAIKRYQQVRN 565

  Fly   632 VQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFL-LTEYCPKGSLQDILENEQFQLDWMF 695
            :  ...:|.:..||.:|..::|:|.||||...:|:..|: :...|.:|||:|||.|::.:|...|
Worm   566 I--TFPKSELRLLKELKICENDNLNKFYGISFNQQNEFIVMWVLCSRGSLEDILFNDELKLGRNF 628

  Fly   696 RLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGL---------HTLRRTRFDL 751
            ::|...|:|:|:.|||:|.:..||.|...||:|||.:.:|:|:|..         |...|...:.
Worm   629 QVSFAKDVVKGLNFLHTSPLLHHGMLCLQNCLVDSNWTVKLTNFATEAVIFEKLDHNELRPFINT 693

  Fly   752 ESDGGNCNSHA----YWSKLLWTAPELLR--VEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYL 810
            :|:..:..|..    ...|.|..|||::|  |.....|||:|..|:||.|:::::|..|..||:
Worm   694 DSESADDVSDPTKDFARKKYLQQAPEIIREIVTTKTIPEGSQSADIYALGMVLYQILFRVEPFH- 757

  Fly   811 GRCAYEKSPQEIIE-LVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLK 874
               ...||..:::| |....:..::.:|..|...........:...|..||.|.|..||....::
Worm   758 ---ERNKSINKLMETLAMANDDDQLIRPTFPSSNTGEGYNLQLLSCIEACWLEIPEMRPPIKKVR 819

  Fly   875 SMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLI 939
            :|:....|....|::||.::|.||.|..|||.:|.:||....|.:|:.::||..:||:|:|..|.
Worm   820 TMVNANLKSTGKGSLVDQMMKMMEEYTANLENMVRDRTALLEEAQKQADRLLNSMLPKSIAEDLK 884

  Fly   940 SGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAY 1004
            .|:||:.:.:...|:.||||.|||.||:.|||:|||.||||:::.||:|:...|.||||||||||
Worm   885 IGKPVLPQLYSCATVLFSDIRGFTRISSTSTPLQVVTFLNDMFSGFDAIIAKHDAYKVETIGDAY 949

  Fly  1005 MVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRY 1069
            |:|||:|..|||.||:.||.:||.:...:.||::.||||:.:.:|||.|:|...||||||..|||
Worm   950 MIVSGVPTENGNSHAQNIADVALKMRAFICNFKLAHRPEELMMVRIGFHSGPVAAGVVGLAAPRY 1014

  Fly  1070 CLFGDTVNTASRMESNGEALKIHISETTKEALD-EFGTFVTTRRGFVPMKGKGEMLTYWLEG 1130
            |||||||||||||||.|.|.||.|||.....|. .|..|....||.:.:|||||.|||:|||
Worm  1015 CLFGDTVNTASRMESTGVANKIQISEGAYNLLHCFFPQFQMVERGKIEVKGKGECLTYYLEG 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	88/453 (19%)
		ANF_receptor	108..473	CDD:279440	77/393 (20%)
		PK_GC-A_B	589..883	CDD:270944	91/312 (29%)
		Pkinase_Tyr	613..877	CDD:285015	83/281 (30%)
		HNOBA	<893..938	CDD:285003	18/44 (41%)
		CYCc	917..1108	CDD:214485	104/191 (54%)
		Guanylate_cyc	944..1130	CDD:278633	105/186 (56%)
gcy-9	NP_509897.3	Periplasmic_Binding_Protein_Type_1	66..416	CDD:299141	82/415 (20%)
		ANF_receptor	69..404	CDD:279440	78/400 (20%)
		PKc_like	550..820	CDD:304357	83/275 (30%)
		HNOBA	<837..883	CDD:285003	18/45 (40%)
		CYCc	862..1054	CDD:214485	104/191 (54%)
		Guanylate_cyc	889..1076	CDD:278633	105/186 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920