DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and gcy-6

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_001294696.1	Gene:	gcy-6 / 191644	WormBaseID:	WBGene00001533	Length:	1086	Species:	Caenorhabditis elegans

Alignment Length:	1084	Identity:	340/1084 - (31%)
Similarity:	531/1084 - (48%)	Gaps:	127/1084 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 LAIRHVQRMGFVGGSHFDIQLISRDTFCSSKYGPIGFFEIYTQWPEVNAVFGLPCEYVLAPISRY 178
            :||..::|.|.:.|..|...::...  |..........:::.: ..|:.:||........|:...
Worm    60 IAIDKIKREGLLLGYDFKFTILYDQ--CDENIAAGNAIKLFAE-HNVDVLFGPTTNNAAMPVFIL 121

  Fly   179 ADVWQVPVLTTGGNAKEFNKKSESYSTL---TRLKGAQVNNLGN-----VVRAILNSFNWTRTAL 235
            |..:.:|::|.|         ..|.:||   :|...|.:.::|:     ..|.::..:.|.:...
Worm   122 ATYYNIPLITWG---------ITSSATLDDESRFPTAGMLSIGSRSLAVTFREVMKEYGWDQFVF 177

  Fly   236 IYQNENAKVKGNSV--CFLCLAAIHDTIEEHSVYQLGFDTSTWTKADITRMLKNVAMQSRIVIMC 298
            .|..|....|..::  .|..:.|.:..|    |..........::..:..:||:|:.:.||::.|
Worm   178 AYSLEMNDEKCETLRDDFQNMVAYYGDI----VLSYAVQIMDHSEEGLLAILKDVSTRGRIIVPC 238

  Fly   299 ADPQSIRQI----MLTAEELNMIDSGEYVFINIELFSRVQYLTSQ-------PWYDKNDTDLNNE 352
            ....:.|.:    ||.|.....::. |||:|...|.|| .|...|       ||.:.......::
Worm   239 FHEGNSRGLHRRWMLVAARNGFVND-EYVYIFPSLRSR-GYAVPQADGTFRYPWTEATGPQPGDQ 301

  Fly   353 RAQKAYTAMLTVTPKQPNDN---EYTRVSNE-IKAIAAEKYNYTFSDNEP----ISAFVTSFFDG 409
            .|...:...:.:...|...|   .||:..:| |:.:....||.|.:...|    .:.:.....|.
Worm   302 EALLGFQKSIFIVDMQGQGNVGSNYTQFEHEIIQRMKEPPYNCTDACASPEYQTAATYAGQLHDS 366

  Fly   410 VLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANG-----------DRLS 463
            |.:|...:::.::..|....   |||...|:|.. .|.|:.|.|.||..|           |..:
Worm   367 VYIYGVVMDQIMKTVPNQYK---NGTAFPRKMAG-VFNGVGGTVAIDEGGGLQPTLFVLTLDSNN 427

  Fly   464 AYSLLDMNPTTGRFEIVA--HFLHNRLEFEANKEIHWAGDREEAPPDRPICGYDGALCPDN---S 523
            ..||: |.....:.|.|.  |:.:.....       |:..:...|||:|||||.|:|||.|   .
Worm   428 NSSLI-MTVDVDQQEAVVTKHYTNEATAL-------WSHRKGIRPPDQPICGYTGSLCPANVFFQ 484

  Fly   524 LPGYAILSIVLGTMVVVMAVCFFFGYRHYIA-----EAEINSMSWKVSLEDVMFRDAAERGLRGS 583
            ..|:.|.:|::....::.|:..|.    |:.     |.|..:..|::..:.:|......:| ..|
Worm   485 YIGWFIAAIIIIFFTIMGAILAFI----YLCHAKQQEVERQNALWQIPFKSMMTVTKKGKG-EHS 544

  Fly   584 FHSLVKQSSQLTLMSEDMVSINGDRQ--IFIPV-GMFRKSKVAIKPVEVDNVQGLLTRSLMLELK 645
            ..|:....|.::......:|..|:.:  :|..: ......:||.|.   .:::.:........::
Worm   545 MRSISSVPSTISSTRSSTLSEVGETRNYLFFQIQNDVEMERVAAKK---HSIRMVFDNKTCATMR 606

  Fly   646 RMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFL 710
            :|:.:.|.:|.||.|..||..:.:.:..:|.:|||.|::.....|:|..|..|||.||:.|:.::
Worm   607 QMRLIDHANLNKFIGMSLDAPQLYSVWRFCSRGSLADVIRKASMQMDGFFIYSLMKDIINGLTWI 671

  Fly   711 HSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSK--LLWTAPE 773
            |.|....||.|.|.||:::.|:.||||||||...|              :|..::|  .|||:||
Worm   672 HESSHEFHGMLTSKNCLLNDRWQLKITDFGLRIFR--------------THDQYNKSDRLWTSPE 722

  Fly   774 LLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPF 838
            |||.:...   |:::||:|:||||..|:.||...|.|..  .::..:|||.::|   ...:|.|
Worm   723 LLRTDDIL---GSREGDIYSFGIISAELITRSSVFDLEN--RKEDAEEIIYMLK---KGGLQSP- 778

  Fly   839 RPELEPNGDTKADIN----GIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMEL 899
            ||.||  .|...:||    .::|.||.|.|:||||...:.|.:|..| .|...|::|::...:|.
Worm   779 RPSLE--HDESIEINPALLHLVRDCWTERPSERPDIKQVASQLRSMN-TNRNDNLMDHVFNVLES 840

  Fly   900 YANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTA 964
            ||:.||:.|.||.::..|||||.:.|||::||:.||.:|..||.|..||||.||::|||:|.||.
Worm   841 YASTLEDEVAERMKELVEEKKKSDVLLYRMLPRQVADKLKLGQTVEPETFDIVTLFFSDVVSFTT 905

  Fly   965 ISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALAL 1029
            ::.:.||:|||..||.|||.||.|:|..||||||||||.|.|.||:|.||||:|.|.||.:::..
Worm   906 LAGKCTPLQVVNLLNGLYTIFDGIIEQHDVYKVETIGDGYFVASGVPRRNGNEHTRNIASMSINF 970

  Fly  1030 LEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHIS 1094
            ::::.:|.|.|.|.:::|:|:|.|.|:.|||||||.|||||||||.||||||||||.:..:||:|
Worm   971 VKSLADFSIPHLPGEKIKIRVGFHCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNSKPGQIHLS 1035

  Fly  1095 ETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWL----EGEVPR 1134
            |...:.|...|.|.|..||.|.:||||.|.||||    |...|:
Worm  1036 EEANQMLMRLGGFTTEPRGEVIIKGKGVMATYWLLKMDESAAPK 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	85/425 (20%)
		ANF_receptor	108..473	CDD:279440	82/398 (21%)
		PK_GC-A_B	589..883	CDD:270944	95/302 (31%)
		Pkinase_Tyr	613..877	CDD:285015	89/270 (33%)
		HNOBA	<893..938	CDD:285003	20/44 (45%)
		CYCc	917..1108	CDD:214485	106/190 (56%)
		Guanylate_cyc	944..1130	CDD:278633	105/189 (56%)
gcy-6	NP_001294696.1	PBP1_NPR_GC_like	29..445	CDD:107347	84/407 (21%)
		ANF_receptor	57..424	CDD:279440	78/385 (20%)
		PKc_like	585..822	CDD:304357	90/264 (34%)
		HNOBA	<847..879	CDD:285003	15/31 (48%)
		CYCc	858..1048	CDD:214485	106/189 (56%)
		Guanylate_cyc	885..1070	CDD:278633	104/184 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7809
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020