DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and gcy-5

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_496219.1	Gene:	gcy-5 / 191643	WormBaseID:	WBGene00001532	Length:	1122	Species:	Caenorhabditis elegans

Alignment Length:	1143	Identity:	348/1143 - (30%)
Similarity:	547/1143 - (47%)	Gaps:	178/1143 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 LELAIRHVQRMGFVGGSHFDIQLISRDTFCS----SKYGPIGFFEIYTQWPEVNAVFGLPCEYVL 172
            |.:|:::::..||:  :.||::.....|.|.    :|.|.....|:     .|:.|.|..|...|
Worm    53 LPIAVQYLKSKGFL--TDFDVEYYMEYTECDRASVAKAGMKFMKEM-----NVDVVVGPSCGDAL 110

  Fly   173 APISRYADVWQVPVLTTG-------GNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNW 230
            |.:...:.:::..||..|       .:...|...:....|        ...||.....||..|.:
Worm   111 AIMGTLSAIYKKLVLGWGFVSDTQLADTNRFPYVASVQPT--------AQTLGLATSRILEMFQF 167

  Fly   231 TRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHSVY--------QLGFDTSTWTKADITRMLKN 287
            .|.||:|..::     ...|...:..:..|:.:..:|        :|..|....|::    .|:.
Worm   168 DRVALLYYKDD-----QDYCKSVMDDVEATLSDPDLYPVRIVWKGELQSDNEALTRS----TLQA 223

  Fly   288 VAMQSRIVIMCA--DPQSIRQIMLTAEELNMIDSGEYVFINIELFS---RVQYLTSQPWYDKNDT 347
            |..::|||::||  .|:. |..:::..:.|| .:.|||.|.:.:.|   .||....:..:....|
Worm   224 VKSRARIVLLCAISGPEK-RNYLISIAQQNM-TTNEYVHILLTMRSIGYGVQTSLGKKTFANGLT 286

  Fly   348 DL----------NNERAQKAYTAMLTV-TPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISA 401
            .|          |...|::|...||.: ......|.|:.:...:..|.|........:.:|.|:|
Worm   287 PLWESFTVAPDGNETNARRAAEKMLVIDVNSDVQDAEFLQYLTKNIADAVRNPPMKCNTSECINA 351

  Fly   402 FVTS-------FFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANG 459
            ..||       .||...||..|:::....|||:    ....:::......||.|:||.|.|..|.
Worm   352 SSTSMGSYARHLFDVFYLYGMAVSKLNSTDPTV----YGNLNLLMPQMVTSFDGMTGRVQIGQNL 412

  Fly   460 DRLSAYSLLDMNPTTGRFEIVAHFLHNRLEFEANKEI-------------HWAGDREEAPPDRPI 511
            .|:..|.|..::.   ::|.||  |.|...:.::.::             .|.|.|   |.|.||
Worm   413 YRVPTYQLYGLDE---KYEQVA--LVNMTFYNSSSQLSRGYSDEGRSVWHFWDGTR---PLDTPI 469

  Fly   512 CGYDGALCPDNSLPGYAIL----SIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKV-SLEDVM 571
            ||:.|..||......|.:|    ||||..::.:|.:||.|..|...||.|..:..|:: |::.:|
Worm   470 CGFSGRYCPVQFWDQYGVLIFVASIVLIFLICIMLMCFGFMIRGRRAEQERLNSEWQIPSIQLIM 534

  Fly   572 FRDAAERGLRGSFHSLVKQSSQLTLMSEDMVSINGDRQIFIPVGMFRKSKVAIKPVEVDNVQGLL 636
              ...|:....|..||  ||...|:..|..::|:|.......|.||.|..|            |.
Worm   535 --PQKEKRKPNSRRSL--QSGPSTITGESKMTIDGGFHENYTVQMFEKDLV------------LT 583

  Fly   637 TRSLMLELK--------RMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDW 693
            |:...:::.        :::.|:||:|.||.|..:|..:...:.:.|.:||||||:....|.:|.
Worm   584 TKHHSMQMNKEEKEKFVKLRKLEHDNLNKFIGLSIDGPQFVAVWKMCSRGSLQDIIARGNFSMDG 648

  Fly   694 MFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGL------HTLRRTRFDLE 752
            .|...::.||..||.|||.|.:..||||:|:.|:|:..:.:|:|||||      ||..:.|
Worm   649 FFMFCIITDIAEGMNFLHKSFLHLHGNLRSATCLVNDSWQVKLTDFGLGALLEEHTPSKKR---- 709

  Fly   753 SDGGNCNSHAYWSKLLWTAPELLR---VEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCA 814
                          |||.|||:||   ..|...|    ..|||:|.||..||.|::..:.:..
Worm   710 --------------LLWAAPEVLRGSLTIHQMDP----SADVYSFAIIASEILTKREAWDISN-- 754

  Fly   815 YEKSPQEIIELV-KGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIR 878
            .::...||:.:| ||.|     :..||||..:.:....:..:::.||:|.|.:||....:..::.
Worm   755 RKEGADEILYMVKKGGN-----RTIRPELILDAEVSPRLTTLVKDCWSEQPEDRPKAEQICKLLS 814

  Fly   879 RFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQP 943
            .......| |::|::...:|.|.:.||..:||||::...||||.:.||.::||:.||.:|.:||.
Worm   815 EMTPRGNT-NLMDHVFNMLEEYTSTLEVDIEERTKELTLEKKKADILLSRMLPKQVAERLKAGQT 878

  Fly   944 VVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVS 1008
            |..|.||.||:.|||:|.||.::|:.:|.|||..|||||:.||:|:|...|||||:|||.|:.||
Worm   879 VEPEGFDTVTVLFSDVVKFTQLAAKCSPFQVVNLLNDLYSNFDTIIEEHGVYKVESIGDGYLCVS 943

  Fly  1009 GLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFG 1073
            |||.:||..|.::|..::|..::...:|::.|.|.::::||||:::|.||||||||.||||||||
Worm   944 GLPTKNGYAHIKQIVDMSLKFMDYCKSFKVPHLPREKVELRIGINSGPCVAGVVGLSMPRYCLFG 1008

  Fly  1074 DTVNTASRMESNGEALKIHISETTKEALDEF--GTFVTTRRGFVPMKGKGEMLTYWLEGEVPRPN 1136
            |||||||||||||:...||:||.....|.:.  ..:.|:.||.|.:||||.|.|:|:.|:.....
Worm  1009 DTVNTASRMESNGKPSMIHMSEAAHSLLTDHYPHQYETSSRGEVIIKGKGVMETFWVLGKTDSDT 1073

  Fly  1137 SLIS------------PSKLM--LTRRSSLKQPQRSQS 1160
            ..:|            |.::.  |.:|:....|:|.:|
Worm  1074 KSLSTRTTPPITDENWPPQMKEDLKKRAVTPYPERQRS 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	95/440 (22%)
		ANF_receptor	108..473	CDD:279440	90/402 (22%)
		PK_GC-A_B	589..883	CDD:270944	90/311 (29%)
		Pkinase_Tyr	613..877	CDD:285015	84/281 (30%)
		HNOBA	<893..938	CDD:285003	18/44 (41%)
		CYCc	917..1108	CDD:214485	100/192 (52%)
		Guanylate_cyc	944..1130	CDD:278633	98/187 (52%)
gcy-5	NP_496219.1	PBP1_NPR_GC_like	30..440	CDD:107347	95/421 (23%)
		ANF_receptor	49..426	CDD:279440	90/405 (22%)
		PK_GC	546..816	CDD:270894	92/312 (29%)
		HNOBA	<830..873	CDD:285003	18/42 (43%)
		CYCc	852..1042	CDD:214485	100/189 (53%)
		Guanylate_cyc	879..1067	CDD:278633	98/187 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7809
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910