DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and gcy-3

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_496037.1	Gene:	gcy-3 / 191641	WormBaseID:	WBGene00001530	Length:	1140	Species:	Caenorhabditis elegans

Alignment Length:	1182	Identity:	359/1182 - (30%)
Similarity:	554/1182 - (46%)	Gaps:	237/1182 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 LAIRHVQRMGFVGGSHFDIQLISRDTFC---SSKYGPIGFFEIYTQWPEVNAVFGLPCEYVLAPI 175
            |||..:::.|:|  ::||.:.....|.|   |:....|.|.:..    ||:.:.|.||...:..:
Worm    61 LAIERLKQAGYV--TNFDFEYYVEYTECDLASTVRTGINFLKNL----EVDVIIGPPCSEAIRTM 119

  Fly   176 SRYADVWQVPVLTTGGNAKEFNKKSESYSTLTR-------LKGAQVNNLGNVVRAILNSFNWTRT 233
            :..|.:::.|||..|     |..::: .|.:||       |..:|  .||.....:|..:.|.:.
Worm   120 ATLATLYKKPVLGWG-----FVSQAD-LSDMTRFPYLITVLPTSQ--TLGYAASKLLELYKWDKV 176

  Fly   234 ALIYQNENAKVKGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTWTKADI--------TRMLKNVAM 290
            ||:|.....     :.|...:..:..|..:.|.|.:    ....||:|        ..::.:|..
Worm   177 ALLYYKSEV-----NHCGGVMNDVETTFNDPSTYSI----QIVLKAEIDASDNVTTNAVISSVKT 232

  Fly   291 QSRIVIMCADPQS-IRQIMLTAEELNMIDSGEYVFINIELFS--------------RVQYLTSQP 340
            ::||::.||...| .|..|:...:|. :|:.|||.:.|.:.|              ::..||  |
Worm   233 RARIILWCAQLGSEKRDYMIKISQLG-LDTDEYVHVLISMRSIGFGVQTFVGKTTFKLSGLT--P 294

  Fly   341 WYD--KNDT-----------------DLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIK--AI 384
            .::  .|.|                 |||:|.:.|||.           |.....:.|.:|  .:
Worm   295 VWESFSNVTDGLENVAKRGATNVLVIDLNSEVSDKAYL-----------DYMQRNILNVVKLPPL 348

  Fly   385 AAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTD--------MVRRM 441
            .....:...|....:.|:....||.|.||..|           ||| :|.||        .:...
Worm   349 NCSTVDCVSSTATGMGAYARHLFDVVYLYGIA-----------LTR-VNSTDSAVYDDMSKLIPQ 401

  Fly   442 WNRSFTGITGNVTIDANGDRLSAY------------SLLDMNPTTGRFEIVAHFLHNRLEFEANK 494
            :..||.|:||.|.|:.|..|:..|            ||::::...|.........::.   |::.
Worm   402 FVTSFNGMTGLVAINQNLSRMPLYQLYGLDEQYEQTSLMNLSFADGTTVATISLAYSN---ESSA 463

  Fly   495 EIH-WAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGT-----MVVVMAVCFFFGYRHYI 553
            ..| |.|.|   |...||||:.|..||......|.|| |.:|.     |:....:||.|..::..
Worm   464 VWHFWGGIR---PLATPICGFLGNSCPLPFWEQYGIL-IFVGAGVFLIMITTNLICFLFMIKNRR 524

  Fly   554 AE-AEINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQSSQLTLMSEDMVSINGDRQIFIPVGMF 617
            .| |.||| .|::..  |..|:...:....|..||  ||:..|:..|..||...:......|.||
Worm   525 EEQARINS-EWQIPF--VKLRELERKSKGTSKRSL--QSAPSTITGESKVSTGSEFCENYEVKMF 584

  Fly   618 RKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQD 682
            .|..|.....:..|    |.::.|.:..:::.|.|::|.||.|..:|..:...:|:.|.:|||.|
Worm   585 EKDMVLTMKFQYMN----LNKADMDKFVKLRKLDHENLNKFIGLSIDSSQFISVTKLCSRGSLLD 645

  Fly   683 ILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFG----LHT 743
            ||....|.:|:.|...::.|:..||.:||.|.:|.||||:|:.|:|:..:.:|:.:||    |..
Worm   646 ILYKGNFSMDFFFMYCIIKDVAEGMSYLHKSFLRLHGNLRSATCLVNDSWQVKLAEFGFDQLLEE 710

  Fly   744 LRRTRFDLESDGGNCNSHAYWSKLLWTAPELLR----VEHNRPPEGTQKGDVYAFGIIVHEITTR 804
            :..|:                .:|||.|||:||    |....|     ..||::|.||..||.||
Worm   711 ITPTK----------------RRLLWAAPEVLRGSLTVSQMDP-----SADVFSFAIIASEILTR 754

  Fly   805 QGPFYLGRCAYEKSPQEIIELVKGYNP--HRMQK----PFRPELEPN-GDTKADINGIIRRCWAE 862
                        |...::.|..:||:.  :|::|    |.||::..: .|....:..:::.||||
Worm   755 ------------KEAWDLKERKEGYDEIIYRVKKGGSFPIRPDIITDVPDVNPTLIALVKDCWAE 807

  Fly   863 DPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLY 927
            .|.:||....:...:|......:: |::|::...:|.|.:.||..|||||::...||||.:.||.
Worm   808 APEDRPTAENICEQLRDLMPKTKS-NLMDHVFNMLEEYTSTLEVEVEERTKELTLEKKKADLLLS 871

  Fly   928 QLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENF 992
            ::||:.||.:|.:||.|..|.||.||::|||:|.||.::::.||.|||..|||||:.||:|:|..
Worm   872 RMLPKQVAERLKAGQTVEPEGFDSVTVFFSDVVKFTILASKCTPFQVVNLLNDLYSNFDTIIEEH 936

  Fly   993 DVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGAC 1057
            .|||||:|||.|:.|||||.|||..|.::|..::|..::...||:|.|.|.:|::||||:::|.|
Worm   937 GVYKVESIGDGYLCVSGLPTRNGFNHIKQIVDMSLKFMDYCKNFKIPHLPRERVELRIGVNSGPC 1001

  Fly  1058 VAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEA----LDEF-GTFVTTRRGFVPM 1117
            |||||||.|||||||||||||||||||||:...||:   |.:|    :..| ..:.|..||.|.:
Worm  1002 VAGVVGLSMPRYCLFGDTVNTASRMESNGKPSLIHL---TSDAHLLLMKHFPHQYETNSRGEVII 1063

  Fly  1118 KGKGEMLTYWLEGEVPRPNSLISPSKLMLTRRS---------SLKQP-------------QRSQS 1160
            ||||.|.|:|:.|.    :..|.||   ::.||         :::.|             :.|.:
Worm  1064 KGKGVMETFWVLGR----SGDIEPS---ISNRSTPPVTQERFTVRAPDTPEARSVSSHGSRPSSN 1121

  Fly  1161 HN-----LHKQY 1167
            ||     |::||
Worm  1122 HNNNNDPLYRQY 1133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	101/458 (22%)
		ANF_receptor	108..473	CDD:279440	98/432 (23%)
		PK_GC-A_B	589..883	CDD:270944	88/308 (29%)
		Pkinase_Tyr	613..877	CDD:285015	81/278 (29%)
		HNOBA	<893..938	CDD:285003	19/44 (43%)
		CYCc	917..1108	CDD:214485	104/195 (53%)
		Guanylate_cyc	944..1130	CDD:278633	102/190 (54%)
gcy-3	NP_496037.1	PBP1_NPR_GC_like	36..453	CDD:107347	99/440 (23%)
		ANF_receptor	54..433	CDD:279440	96/420 (23%)
		PKc_like	554..823	CDD:304357	89/307 (29%)
		HNOBA	<839..882	CDD:285003	19/42 (45%)
		CYCc	861..1051	CDD:214485	104/192 (54%)
		Guanylate_cyc	888..1076	CDD:278633	102/190 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7809
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910