DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and gcy-1

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_496039.1	Gene:	gcy-1 / 191639	WormBaseID:	WBGene00001528	Length:	1137	Species:	Caenorhabditis elegans

Alignment Length:	1120	Identity:	338/1120 - (30%)
Similarity:	537/1120 - (47%)	Gaps:	140/1120 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 LAIRHVQRMGFVGGSHFDIQLISRDTFCSSKYGPI---GFFEIYTQWPEVNAVFGLPCEYVLAPI 175
            |||..::.||||  ..||.:.|...|.|.  .|.:   |...|.|.  :|:.:.|.||...|..:
Worm    60 LAIERLKEMGFV--KDFDFEYIVDYTECD--LGSVVRAGMEFIKTH--KVDVIIGPPCAQALRLM 118

  Fly   176 SRYADVWQVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNN---LGNVVRAILNSFNWTRTALIY 237
            |..|:.::.|||..|..:.........:..||.:    :.|   ||.....:|.:|:|.|.||:|
Worm   119 SFLAENYKKPVLGWGFVSDTDLSDVIRFPHLTTV----IPNSLMLGYAASKMLTTFHWNRVALLY 179

  Fly   238 QNENAKVKGNSVCFLCLAAIHD---TIEEHSVYQLGFDTSTWTKADI--------TRMLKNVAMQ 291
            ...:.|        .|...::|   |..:.|..    :.:...||:|        ..:.:.|..:
Worm   180 YFSDVK--------YCSGVMNDIEATFNDPSTP----NVNIVIKAEIYLNDNETTDNVFQTVKSR 232

  Fly   292 SRIVIMCADPQ-SIRQIMLTAEELNMIDSGEYVFINIELFS---RVQYLTSQPWYDKN------- 345
            :||::.|.... ..|..::.....:|| ..|||.|.:.:.:   ..|....:|.:.::
Worm   233 ARIILWCTQTSVEKRDYLIKIATHDMI-GDEYVHIMLSMRNVAFGTQTSLGKPTFSQSGLTPIWE 296

  Fly   346 ----DTDLNNERAQKAYTAMLTV-TPKQPNDNEYTRV--SNEIKAIAAEKYNYT----FSDNEPI 399
                .||...:.|::|.|.|..: ...:..|.:|...  .|.|||:.:...|.:    .:.|..|
Worm   297 SFTEGTDGFEKMAKQAATRMFVLDVNSEVADKKYLEYMQKNIIKAVQSPPMNCSTVECMTANTTI 361

  Fly   400 -SAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLS 463
             ..:....||.|.||..||..:...||.:    ....|::...:..||.|:||:|.|..|..|:.
Worm   362 MGGYARHLFDVVYLYGIALTHTNSTDPAV----YGDVDVLVHQFVTSFQGMTGHVVISPNLTRMP 422

  Fly   464 AYSLLDMNPTTGRFEIVAHFLHNRLEFEANKEIH--------WAGDREEAPPDRPICGYDGALCP 520
            .:.|..:|....:..:| .|.:.......|..:.        |:......|.|.||||:.|..||
Worm   423 IFQLYGLNSDYDQVALV-DFTYTNSVMVPNVTLFYKDEGGAVWSYYGHSRPLDIPICGFLGKSCP 486

  Fly   521 DNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIA-----EAEINSMSWKVSLEDVMFRDAAERGL 580
            .:....|.||..|...::|:|.:....|....|:     .|.||: .|:|....::..:...||.
Worm   487 VSFWEQYKILIFVAIAVIVLMVLIMIIGCLCVISGKRAERARINA-EWQVPFAKLIESEKQVRGK 550

  Fly   581 RGSFHSLVKQSSQLTLMSEDMVSINGDRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELK 645
            ..|..||  ||:.........|:...|......:.|:.|..|.....:..:    ||::......
Worm   551 GASRRSL--QSAPSISTGHSGVTTVSDFCENYTMMMYEKEMVLTAKYQYTH----LTKADKERFV 609

  Fly   646 RMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFL 710
            :|:.|.|:::.:|.|..:|......:|:.|.:|||||||....|.:|:.|...::.|:.:|:::|
Worm   610 KMRKLDHENINRFIGLSIDSAHFISVTKLCSRGSLQDILSRGNFSMDYFFMFCIIRDVAKGLEYL 674

  Fly   711 HSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELL 775
            |.:.:|.||||:|:.|:|:..:.:|:.::|:..|...:...:            .:|||.|||:|
Worm   675 HKTFLRLHGNLRSATCLVNDSWQVKLAEYGMDNLVEEQTPPK------------KRLLWVAPEVL 727

  Fly   776 R----VEHNRPPEGTQKGDVYAFGIIVHEITTRQGPF-YLGRCAYEKSPQEIIELVKGYNPHRMQ 835
            |    |....|     ..|:|:|.||..||.|::..: .|.|   ::..:||:     ||   ::
Worm   728 RGSLSVSQMEP-----SADIYSFAIIASEILTKKEAWDILDR---KEDCEEIV-----YN---VK 776

  Fly   836 K----PFRPELEPN-GDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLK 895
            |    |.|||:..: .|....:..:::.||||.|.:||....:.|.::......:| |::|::..
Worm   777 KGGLFPIRPEIITDIHDVNPALIALVKDCWAEVPEDRPTAENICSQMKGLVSKQKT-NLMDHVFN 840

  Fly   896 RMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIV 960
            .:|.|.:.|||.:||||::...||||.:.||.::||:.||.:|.:||.|..|.||.||::|||:|
Worm   841 MLEEYTSTLEEEIEERTKELTLEKKKADILLSRMLPKQVAERLKAGQTVEPEGFDSVTVFFSDVV 905

  Fly   961 GFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARL 1025
            .||.::::.:|.|.|..|||||:.||:|:|...|||||:|||.|:.|||||.|||..|.::|..:
Worm   906 KFTILASKCSPFQTVNLLNDLYSNFDTIIEQHGVYKVESIGDGYLCVSGLPTRNGYAHIKQIVDM 970

  Fly  1026 ALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALK 1090
            :|..:|...:|.|.|.|.:.::||||:::|.||||||||.|||||||||||||||||||||:...
Worm   971 SLKFMEYCKSFNIPHLPRENVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSL 1035

  Fly  1091 IHISETTKEALDEF--GTFVTTRRGFVPMKGKGEMLTYWLEGEVPRPNSLISPSKL-MLTRRSSL 1152
            ||::......|...  ..:.|:.||.|.:||||.|.|:|:.|....    :.|::| .::.||:.
Worm  1036 IHLTNDAHSLLTTHYPNQYETSSRGEVIIKGKGVMETFWVHGRFGE----MEPTELRSISNRSTP 1096

  Fly  1153 KQ------PQRSQSH 1161
            ..      |..|.||
Worm  1097 PVTNDRWIPNPSSSH 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	99/431 (23%)
		ANF_receptor	108..473	CDD:279440	96/398 (24%)
		PK_GC-A_B	589..883	CDD:270944	80/303 (26%)
		Pkinase_Tyr	613..877	CDD:285015	76/273 (28%)
		HNOBA	<893..938	CDD:285003	19/44 (43%)
		CYCc	917..1108	CDD:214485	99/192 (52%)
		Guanylate_cyc	944..1130	CDD:278633	97/187 (52%)
gcy-1	NP_496039.1	PBP1_NPR_GC_like	35..449	CDD:107347	98/416 (24%)
		ANF_receptor	53..432	CDD:279440	96/398 (24%)
		PKc_like	555..821	CDD:304357	81/299 (27%)
		HNOBA	<840..883	CDD:285003	19/42 (45%)
		CYCc	862..1051	CDD:214485	99/188 (53%)
		Guanylate_cyc	889..1077	CDD:278633	97/187 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7809
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910