Protein Alignment CG31183 and gcy-20

DIOPT Version :10

• Sequence 1: NP_650505.2
• Gene: CG31183 / 41927
• FlyBaseID: FBgn0051183
• Length: 1417
• Species: Drosophila melanogaster
• Sequence 2: NP_507101.1
• Gene: gcy-20 / 184797
• WormBaseID: WBGene00001545
• Length: 1108
• Species: Caenorhabditis elegans
• Alignment Length: 1094
• Identity: 370/1094 - (33%)
• Similarity: 557/1094 - (50%)
• Gaps: 129/1094 - (11%)

  Fly   130 FDIQLISRDTFCSSKYGPIGFFEIYTQWPEVNAVFGLPCEYVLAPISRYADVWQVPV----LTTG 190
            :|.....:...||.........|:.|. ..|:.:.|..|......::..||.:.|||    |||.
 Worm    63 YDFNFTIKFDECSESLAAGKVVELLTH-DNVDVIIGPTCNRAGVAVASLADFYNVPVFQWGLTTT 126

  Fly   191 GNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLCLA 255
            .:...|::    |.|...| ....:::...||.||..:.|:....||.|:..:.|       | |
 Worm   127 ADIGNFSR----YQTTVTL-SLDTHSISLAVREILRQYGWSEFVFIYSNDGDEEK-------C-A 178

  Fly   256 AIHDTIEEHSVYQLGFDTS-----------TWTKADITRMLKNVAMQSRIVIMC-ADPQSIRQIM 308
            |:.|.:|     ::|.:.|           |.|...:.|.|..|:.:.||:|.| |..:..::..
 Worm   179 AMKDDME-----KMGIENSDVTMAYMIQIQTVTMESLQRTLLEVSKRGRIIIACFASGRGFKKAF 238

  Fly   309 LTAEELNMIDSGEYVFINIELFSRVQYL---TSQPWYDKNDTD------LNNERAQKAYTAMLTV 364
            :.:..|..:.:.||:::..|..||..|:   ..:..|..:|||      |.||:.:.||..:|.:
 Worm   239 IASTVLAGMSTEEYLYVFAEPQSRGFYVDEADGKVHYSWDDTDGQLVTGLTNEQIRDAYGKVLYI 303

  Fly   365 TPK--QPN--DNEYTRVSNE-IKAIAAEKYN----YTFSDNEPISAFVTSFFDGVLLYANALNES 420
            ...  :|.  ..:||..::: |..:|.:.:|    .:....:..:.:.....|....||.|||:|
 Worm   304 CDNMGEPTTITTQYTNFTSQVISRMAEQPFNCVQDCSNQSYKHAATYAGQLADSFYAYAFALNKS 368

  Fly   421 IREDPTMLTRPINGTDMVRRMWNRSFTGITGN-VTIDANGDRLSAYSLLDMNPTTGRFEIVAHFL 484
            :.:|||. :...||:.::..: ..:|.|:.|. ||:|.:|.|:....:..||.:...: :.|..|
 Worm   369 LTQDPTR-SNLKNGSFVLSNI-GMTFQGVGGEAVTLDESGSRIVQVYMFAMNSSLLPY-MAASLL 430

  Fly   485 HNRLE------FEANKEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGTMVV--VM 541
            .|..|      :::..|: |:    ..|..||.||:.|..||.:.:..|.:.:|:...:|:  ::
 Worm   431 VNVSEVVFTPFYKSESEL-WS----VRPLSRPKCGFTGLECPADFVKEYLVYTIIAAFIVILALL 490

  Fly   542 AVCFFFGYRHYI--AEAEINSMSWKVS---LEDVMFRDAAERGLRGSFHSLVKQSSQLTLMSEDM 601
            |.|....|..::  .|.|...:.|:|:   |:.|..:..||    .|.||.....|..|.|:
 Worm   491 AGCAGLLYTMHMKRKEMERQDLLWQVAFVELQQVQSKSRAE----ASMHSFASGPSTSTKMT--- 548

  Fly   602 VSINGDRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQR 666
            |....:...|| ...:.:..||.|.   .::..|...:...|.::|::..:|:|.||.|.|||..
 Worm   549 VESRTETTNFI-FYHYHQEVVAAKK---HDLLVLFDANQKSEFRQMRNFDNDNLNKFIGLCLDGP 609

  Fly   667 RSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSR 731
            :...|..:|.:|||.|::.....|:|..|..||:.||..|:.|:|||.::.||.|.|..|::|.|
 Worm   610 QLLSLWRFCSRGSLSDVISKSSMQMDSFFMFSLIRDISNGLYFIHSSFLKCHGQLTSRCCLIDDR 674

  Fly   732 FVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGI 796
            :.:||:.|||.::|......:.|            |||.:||.||   |...|...:||:|:|||
 Worm   675 WQIKISGFGLKSVRTFENPKKED------------LLWASPEYLR---NEDQERLPEGDIYSFGI 724

  Fly   797 IVHEITTRQGPFYLGRCAYEKSPQEIIELVK--GYNPHRMQKPFRPELEPNGDTKADIN----GI 855
            |..||.||...|.|..  .::.|..||..||  |:|      |.||.|: .|:|.. ||    .:
 Worm   725 ICAEILTRSSAFDLEN--RKEKPDVIIYQVKKGGHN------PTRPSLD-TGETVV-INPALLHL 779

  Fly   856 IRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKK 920
            :|.||.|.|:|||....::|.:... ||....|::|::...:|.||:.|||.|.:||::..||||
 Worm   780 VRDCWTERPSERPSIEQVRSHLNGM-KDGRKTNLMDHVFNMLETYASTLEEEVSDRTKELTEEKK 843

  Fly   921 KCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCF 985
            |.:.|||::||:.||.:|..||.|..|||:||||:|||:|.||.::.:.||:|||..||||||.|
 Worm   844 KSDVLLYRMLPRMVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLAGKCTPLQVVTLLNDLYTIF 908

  Fly   986 DSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRI 1050
            |.|:|..||||||||||.|:.|||||.||||.|.|.|||::|..|.::..||:.|.|.:|:.|||
 Worm   909 DGIIEQNDVYKVETIGDGYLCVSGLPHRNGNDHIRHIARMSLGFLSSLEFFRVQHLPAERINLRI 973

  Fly  1051 GLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDE-FGTFVTTRRGF 1114
            |::.|:.|||||||.|||||||||.|||||||||||:..:||::......|.: .|.|.|..||.
 Worm   974 GINCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGQIHVTAEANRMLTQVVGGFRTESRGE 1038

  Fly  1115 VPMKGKGEMLTYWLEGEVPRPNSLISPSKL---MLTRRSSLKQPQRSQSHNLHK 1165
            |.:||||.|.|:||.||   .:...:|||.   ::..|.|:    ||.|..|.|
 Worm  1039 VIIKGKGVMETFWLLGE---ESGYTAPSKAAPKVIQHRQSI----RSISPILEK 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_650505.2	PBP1_NPR-like	87..493	CDD:380596	95/403 (24%)
		PK_GC-A_B	589..883	CDD:270944	98/299 (33%)
		HNOBA	<890..938	CDD:462234	22/47 (47%)
		CYCc	917..1108	CDD:214485	112/191 (59%)
gcy-20	NP_507101.1	PBP1_NPR_GC-like	22..427	CDD:380575	91/385 (24%)
		Protein Kinases, catalytic domain	536..801	CDD:473864	99/296 (33%)
		HNOBA	<817..861	CDD:462234	21/43 (49%)
		CYCc	840..1032	CDD:214485	112/191 (59%)