Protein Alignment CG31183 and gcy-11

DIOPT Version :10

• Sequence 1: NP_650505.2
• Gene: CG31183 / 41927
• FlyBaseID: FBgn0051183
• Length: 1417
• Species: Drosophila melanogaster
• Sequence 2: NP_001359843.1
• Gene: gcy-11 / 181745
• WormBaseID: WBGene00001537
• Length: 1168
• Species: Caenorhabditis elegans
• Alignment Length: 1273
• Identity: 359/1273 - (28%)
• Similarity: 567/1273 - (44%)
• Gaps: 291/1273 - (22%)

  Fly    26 AWFYDAESVGGVASIG--VGSD---EHSFKTPETKNSHKSQSTELVQHFPSLPMPDHRR----LG 81
            |::|..|..||:.:.|  |.||   |....|.:...|...|....:.....:.:.|.::    ||
 Worm    48 AFYYGLEDGGGITTNGTFVNSDITVEFFDPTVQGNFSIGRQDGNYMSSMLDIMLADTKKNDGLLG 112

  Fly    82 ARRQLVFVALLPSVESDNKNDCIMPKVLPVLELAIRHVQRMGFVGGSHFDIQLISRDTFCSSKYG 146
                      :..||:|.|....:.:......|.:.                       |..:.|
 Worm   113 ----------VVGVENDCKEIAALAQAYDASSLLVN-----------------------CEDQVG 144

  Fly   147 PIGFFEIYTQWPEVNAVFGLPCEYVLAPISRYADVWQVPVLTTGGNAKEFNKKSESYSTLTRLKG 211
            .       :|.|...|:                   |:. .|.||..:.|.|.::|...
 Worm   145 E-------SQMPSSTAL-------------------QMS-STQGGKYRAFAKLAKSVGW------ 176

  Fly   212 AQVNNLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTW 276
               |||     |::|........:.|.::           |..|...::|....|.:.|| :||.
 Worm   177 ---NNL-----AVINFVEDGPADISYHDQ-----------LLDALSAESISLDFVKKGGF-SSTI 221

  Fly   277 TKADITRM------LKNVAMQSRIVIMCAD-PQSIRQIMLTAEELNMIDSGEYVFI---NIE--- 328
            |.|..|.:      :....|::||.::..| |.|....|.....:.::::|:|..:   :||
 Worm   222 TSAMFTGLESVIDVILETYMKTRIYVIVLDLPVSGTFFMNAMSTMGLLETGKYFVVMMSSIESDA 286

  Fly   329 -------------LFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPND--NEYTRVS 378
                         :|..:.|..|       |.|:........|   .|..|....|  :|:|...
 Worm   287 ANYFGFNVNRGNMIFKTIDYGIS-------DADIRQYYRSFMY---FTDVPHYTKDFSDEWTSFQ 341

  Fly   379 NEIKAIAAEKYNYTF------------SDNEPISAFVTSFFDGVLLYANA------------LNE 419
            ..:...|::    ||            ::|:|.|       |....|:.:            |:|
 Worm   342 KRVDGDASK----TFCPPMCNTKAKGIANNDPWS-------DDAYWYSESPSIVDAYDLGRLLSE 395

  Fly   420 SIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVT-IDANGDRLSAYSL---LDMNPTTGRF--- 477
            :::.....|.|  :...:|:.|..|..|.:.|.|| .:.||.....|.|   ...:.:.|..
 Worm   396 TVKVHGASLLR--DPESLVQTMSGRGVTSLLGYVTKFNTNGVSQREYILWAPQQASSSNGPIPLP 458

  Fly   478 ---EIVAHFLHNRLEFEANKEIHWAGDRE------EAPPDRPICGYDGALCPDNSLPGYAILSIV 533
               .:.|..|.   :.:.|..|.|....:      |.|..:|.||::..||| ..:...:.|.|:
 Worm   459 EWATLAARMLP---DGKGNYSIIWKNLTQLGIFNGELPQSKPECGFNNELCP-AGIRNLSELEII 519

  Fly   534 LGTMVVVMAVCFFFGYRHYIA-----EAEINSMSWKVSLEDVMFRDAAERG-LRGSFHSLVKQSS 592
            : ..|.|:|:....|...|||     |..:.|..:.|..:.|...|..:.| .||.  |:::.:.
 Worm   520 V-IAVCVVAILILVGVIAYIARWIAYERRLESSYFLVHRKHVQLVDMTKFGSSRGG--SMIQSAM 581

  Fly   593 QLTLMSEDMVSINGDRQIFIPVGM----------------------------------FRKSKVA 623
            .:....||...:.|....|...|:                                  :..:.|.
 Worm   582 SMRSQYEDSGPVGGATMNFYTNGIRKAAIRRNQMQRSDKGPAANRDEWLEIVDWHLAKYENTLVT 646

  Fly   624 IKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQ 688
            ::  :::..|..|||.:..|:..:.:..|::|.:|:|...:....|.:..|.|:.||.|:|.|:.
 Worm   647 VR--KINKTQLKLTREMKQEIDLLMNETHENLNRFFGLINESDLIFTIHSYGPRKSLMDLLRNDD 709

  Fly   689 FQLDWMFRLSLMHDIVRGMQFLH-SSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLE 752
            .:||.||::|.:.|:|:|:|||| .|.|..|||||||||:||:.:.:|::::|:..:|....:.:
 Worm   710 LRLDRMFKVSFVEDVVKGLQFLHEGSKIGYHGNLKSSNCIVDAYWRIKLSNYGMEQIRVEEPESK 774

  Fly   753 SDGGNCNSHAYWSKLLWTAPELLR---VEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCA 814
            .|           .|||.|||::|   |:|:.......|.|:|:..|:::||..|||||  |...
 Worm   775 PD-----------DLLWFAPEIIRRYAVKHDLSKLELAKADIYSLAIVLYEIYGRQGPF--GDDL 826

  Fly   815 YEKSPQEIIELVKGYNPHRMQKPFRPELEPNGD--TKADIN----------GIIRRCWAEDPAER 867
            .:.  .||||.:|               .|:|.  |:.||:          .::.:||.||||.|
 Worm   827 LDS--DEIIEQLK---------------FPDGGALTRPDIHLITKAPYPLASVVEKCWVEDPASR 874

  Fly   868 PDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQ 932
            |....::.:::..:|..: |||.||::..::.|.||||::::|||:...:|:|:.|.||.||||:
 Worm   875 PSIKKVRELLKPLSKGLK-GNIADNIMNLLDRYRNNLEDVIKERTEQLEDERKRNESLLLQLLPK 938

  Fly   933 SVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKV 997
            |||..|.:||||.||.:|.|:|||||||||||:|::|||:|||..||:|||.||:|::.||.|||
 Worm   939 SVANSLKNGQPVDAEFYDSVSIYFSDIVGFTALSSKSTPLQVVNMLNNLYTNFDTIIDKFDCYKV 1003

  Fly   998 ETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVV 1062
            ||||||||.|||||..|...||.|:|..:|.||:::..|.:.|.|:::|:||||.|||..|.|||
 Worm  1004 ETIGDAYMFVSGLPEVNSYLHAGEVASASLELLDSIKTFTVSHCPDEKLRLRIGNHTGPVVTGVV 1068

  Fly  1063 GLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYW 1127
            |::|||||||||||..|:.|||:||.::|.||....|.:.:.|.:||.:|..:.:|.|.|::|||
 Worm  1069 GIRMPRYCLFGDTVIIANMMESSGEPMRIQISSDAYELILKCGGYVTEQREKIVLKNKLEVMTYW 1133

  Fly  1128 LEGEVPRPNSLISPSKLMLTRRSSLKQPQRSQSHNLHK 1165
            :       |.....::|........|.|.  ..|.:||
 Worm  1134 M-------NDYSKDARLARLVAHQEKFPH--LEHLIHK 1162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_650505.2	PBP1_NPR-like	87..493	CDD:380596	82/467 (18%)
		PK_GC-A_B	589..883	CDD:270944	91/343 (27%)
		HNOBA	<890..938	CDD:462234	22/47 (47%)
		CYCc	917..1108	CDD:214485	111/190 (58%)
gcy-11	NP_001359843.1	Periplasmic_Binding_Protein_type1	<234..452	CDD:471960	45/240 (19%)
		Protein Kinases, catalytic domain	640..890	CDD:473864	86/281 (31%)
		CYCc	923..1116	CDD:214485	112/192 (58%)