DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and Npr1

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_032753.5	Gene:	Npr1 / 18160	MGIID:	97371	Length:	1057	Species:	Mus musculus

Alignment Length:	1105	Identity:	490/1105 - (44%)
Similarity:	668/1105 - (60%)	Gaps:	102/1105 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 MPDHRRLGAR-RQLVFVALLPSVESDNKNDCIMPKVLPV---------------LELAIRHVQ-R 121
            ||..||:..| |.|:.:..|..:.|.:.:|..:..|||:               :|||:..|: |
Mouse     1 MPGSRRVRPRLRALLLLPPLLLLRSGHASDLTVAVVLPLTNTSYPWSWARVGPAVELALGRVKAR 65

  Fly   122 MGFVGGSHFDIQLISRDT---FCSSKYGPIGFFEIYTQWPEVNAVF-GLPCEYVLAPISRYADVW 182
            ...:.|....:.|.|.:.   .||....|:...::  :|....||| |..|.|..||:.|:...|
Mouse    66 PDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDL--KWEHSPAVFLGPGCVYSAAPVGRFTAHW 128

  Fly   183 QVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTALIYQNENAKVKGN 247
            :||:||.|..|.....|.| |:..||...:.| .||:.|.|:.....|...||:...:  ::..:
Mouse   129 RVPLLTAGAPALGIGVKDE-YALTTRTGPSHV-KLGDFVTALHRRLGWEHQALVLYAD--RLGDD 189

  Fly   248 SVCFLCLAAIHDTIEE-------HSVYQLGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSIR 305
            ..||..:..::..:.|       |..:..| |...:||     :|:.|..:.|::.:|:.|.:.|
Mouse   190 RPCFFIVEGLYMRVRERLNITVNHQEFVEG-DPDHYTK-----LLRTVQRKGRVIYICSSPDAFR 248

  Fly   306 QIMLTAEELNMIDSG----EYVFINIELFSRVQY-----LTSQPWYDKNDTDLNNERAQKAYTAM 361
            .:||.|     :|:|    :|||.::::|.:...     :..:||  :.| |..:.||::|:.|.
Mouse   249 NLMLLA-----LDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPW--ERD-DGQDRRARQAFQAA 305

  Fly   362 LTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPT 426
            ..:|.|:|::.||.....::|.:|.:|:|:|..|... :....||.||:|||..|:.|::.:..|
Mouse   306 KIITYKEPDNPEYLEFLKQLKLLADKKFNFTMEDGLK-NIIPASFHDGLLLYVQAVTETLAQGGT 369

  Fly   427 MLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHNRLEFE 491
            :    .:|.::.:|||||||.|:||.:.||.||||.:.:||.||:|.||.|.:|.:|.....|..
Mouse   370 V----TDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELM 430

  Fly   492 ANKE--IHWAGDREEAPPDRPICGYDG--ALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHY 552
            |..|  ::|  .....|||.|.||:|.  ..|..:......:|::|....:|...:..||.||..
Mouse   431 AVSEHRLYW--PLGYPPPDIPKCGFDNEDPACNQDHFSTLEVLALVGSLSLVSFLIVSFFIYRKM 493

  Fly   553 IAEAEINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQSSQLTLMSE-----DMVSINGDRQIFI 612
            ..|.|:.|..|:|..||:. ..:.||.||.:       .|:|||...     .:::..|..|:|.
Mouse   494 QLEKELVSELWRVRWEDLQ-PSSLERHLRSA-------GSRLTLSGRGSNYGSLLTTEGQFQVFA 550

  Fly   613 PVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPK 677
            ....::.:.||:|.|....::  |||.::.|||.|:|:|::||.:|.|||.|.....:||||||:
Mouse   551 KTAYYKGNLVAVKRVNRKRIE--LTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPR 613

  Fly   678 GSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLH 742
            ||||||||||...||||||.||.:|||:||.|||:..|.|||||||||||||.||||||||:||.
Mouse   614 GSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLE 678

  Fly   743 TLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGP 807
            :.|    |.|.:.|    |..::|.|||||||||:. :.|..|:|.||||:||||:.||..|.|.
Mouse   679 SFR----DPEPEQG----HTLFAKKLWTAPELLRMA-SPPARGSQAGDVYSFGIILQEIALRSGV 734

  Fly   808 FYLGRCAYEKSPQEIIELV-KGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFN 871
            ||:.  ..:.||:||||.| :|..|     ||||.::.....: ::..:::|||||||.|||.|.
Mouse   735 FYVE--GLDLSPKEIIERVTRGEQP-----PFRPSMDLQSHLE-ELGQLMQRCWAEDPQERPPFQ 791

  Fly   872 TLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAA 936
            .::..:|:|||:| :.||:||||.|||.||||||||||||||.|.|||:|.|.||||:||.|||.
Mouse   792 QIRLALRKFNKEN-SSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAE 855

  Fly   937 QLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIG 1001
            ||..|:.|.||.||.|||||||||||||:||||||||||..|||||||||::::|||||||||||
Mouse   856 QLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIG 920

  Fly  1002 DAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKM 1066
            ||||||||||:|||..||||:||:|||||:||.:|||.|||:::|:||||:|||...||||||||
Mouse   921 DAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKM 985

  Fly  1067 PRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE 1131
            |||||||||||||||||||||||:||:|..||..|:||..|....||.|.|||||::.||||.||
Mouse   986 PRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050

Fly 1132 1131
Mouse 1051 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	129/447 (29%)
		ANF_receptor	108..473	CDD:279440	117/400 (29%)
		PK_GC-A_B	589..883	CDD:270944	142/299 (47%)
		Pkinase_Tyr	613..877	CDD:285015	132/264 (50%)
		HNOBA	<893..938	CDD:285003	34/44 (77%)
		CYCc	917..1108	CDD:214485	144/190 (76%)
		Guanylate_cyc	944..1130	CDD:278633	140/185 (76%)
Npr1	NP_032753.5	PBP1_NPR_A	32..439	CDD:107380	126/431 (29%)
		ANF_receptor	50..410	CDD:279440	113/384 (29%)
		PK_GC-A_B	530..803	CDD:270944	138/291 (47%)
		TyrKc	543..797	CDD:197581	135/272 (50%)
		HNOBA	<812..857	CDD:285003	34/44 (77%)
		CYCc	836..1025	CDD:214485	144/188 (77%)
		Guanylate_cyc	863..1049	CDD:278633	140/185 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839019
Domainoid	1	1.000	295	1.000	Domainoid score	I1479
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	809	1.000	Inparanoid score	I483
Isobase	1	0.950	-	0	Normalized mean entropy	S3594
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002376
OrthoInspector	1	1.000	-	-		otm42937
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5404
SonicParanoid	1	1.000	-	-		X2472
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.630