Protein Alignment CG31183 and Npr1

DIOPT Version :10

• Sequence 1: NP_650505.2
• Gene: CG31183 / 41927
• FlyBaseID: FBgn0051183
• Length: 1417
• Species: Drosophila melanogaster
• Sequence 2: NP_032753.5
• Gene: Npr1 / 18160
• MGIID: 97371
• Length: 1057
• Species: Mus musculus
• Alignment Length: 1105
• Identity: 490/1105 - (44%)
• Similarity: 668/1105 - (60%)
• Gaps: 102/1105 - (9%)

  Fly    74 MPDHRRLGAR-RQLVFVALLPSVESDNKNDCIMPKVLPV---------------LELAIRHVQ-R 121
            ||..||:..| |.|:.:..|..:.|.:.:|..:..|||:               :|||:..|: |
Mouse     1 MPGSRRVRPRLRALLLLPPLLLLRSGHASDLTVAVVLPLTNTSYPWSWARVGPAVELALGRVKAR 65

  Fly   122 MGFVGGSHFDIQLISRDT---FCSSKYGPIGFFEIYTQWPEVNAVF-GLPCEYVLAPISRYADVW 182
            ...:.|....:.|.|.:.   .||....|:...::  :|....||| |..|.|..||:.|:...|
Mouse    66 PDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDL--KWEHSPAVFLGPGCVYSAAPVGRFTAHW 128

  Fly   183 QVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTALIYQNENAKVKGN 247
            :||:||.|..|.....|.| |:..||...:.| .||:.|.|:.....|...||:...:  ::..:
Mouse   129 RVPLLTAGAPALGIGVKDE-YALTTRTGPSHV-KLGDFVTALHRRLGWEHQALVLYAD--RLGDD 189

  Fly   248 SVCFLCLAAIHDTIEE-------HSVYQLGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSIR 305
            ..||..:..::..:.|       |..:..| |...:||     :|:.|..:.|::.:|:.|.:.|
Mouse   190 RPCFFIVEGLYMRVRERLNITVNHQEFVEG-DPDHYTK-----LLRTVQRKGRVIYICSSPDAFR 248

  Fly   306 QIMLTAEELNMIDSG----EYVFINIELFSRVQY-----LTSQPWYDKNDTDLNNERAQKAYTAM 361
            .:||.|     :|:|    :|||.::::|.:...     :..:||  :.| |..:.||::|:.|.
Mouse   249 NLMLLA-----LDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPW--ERD-DGQDRRARQAFQAA 305

  Fly   362 LTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPT 426
            ..:|.|:|::.||.....::|.:|.:|:|:|..|... :....||.||:|||..|:.|::.:..|
Mouse   306 KIITYKEPDNPEYLEFLKQLKLLADKKFNFTMEDGLK-NIIPASFHDGLLLYVQAVTETLAQGGT 369

  Fly   427 MLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHNRLEFE 491
            :    .:|.::.:|||||||.|:||.:.||.||||.:.:||.||:|.||.|.:|.:|.....|..
Mouse   370 V----TDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELM 430

  Fly   492 ANKE--IHWAGDREEAPPDRPICGYDG--ALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHY 552
            |..|  ::|  .....|||.|.||:|.  ..|..:......:|::|....:|...:..||.||..
Mouse   431 AVSEHRLYW--PLGYPPPDIPKCGFDNEDPACNQDHFSTLEVLALVGSLSLVSFLIVSFFIYRKM 493

  Fly   553 IAEAEINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQSSQLTLMSE-----DMVSINGDRQIFI 612
            ..|.|:.|..|:|..||:. ..:.||.||.:       .|:|||...     .:::..|..|:|.
Mouse   494 QLEKELVSELWRVRWEDLQ-PSSLERHLRSA-------GSRLTLSGRGSNYGSLLTTEGQFQVFA 550

  Fly   613 PVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPK 677
            ....::.:.||:|.|....::  |||.::.|||.|:|:|::||.:|.|||.|.....:||||||:
Mouse   551 KTAYYKGNLVAVKRVNRKRIE--LTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPR 613

  Fly   678 GSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLH 742
            ||||||||||...||||||.||.:|||:||.|||:..|.|||||||||||||.||||||||:||.
Mouse   614 GSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLE 678

  Fly   743 TLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGP 807
            :.|    |.|.:.|    |..::|.|||||||||:. :.|..|:|.||||:||||:.||..|.|.
Mouse   679 SFR----DPEPEQG----HTLFAKKLWTAPELLRMA-SPPARGSQAGDVYSFGIILQEIALRSGV 734

  Fly   808 FYLGRCAYEKSPQEIIELV-KGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFN 871
            ||:.  ..:.||:||||.| :|..|     ||||.::.....: ::..:::|||||||.|||.|.
Mouse   735 FYVE--GLDLSPKEIIERVTRGEQP-----PFRPSMDLQSHLE-ELGQLMQRCWAEDPQERPPFQ 791

  Fly   872 TLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAA 936
            .::..:|:|||:| :.||:||||.|||.||||||||||||||.|.|||:|.|.||||:||.|||.
Mouse   792 QIRLALRKFNKEN-SSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAE 855

  Fly   937 QLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIG 1001
            ||..|:.|.||.||.|||||||||||||:||||||||||..|||||||||::::|||||||||||
Mouse   856 QLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIG 920

  Fly  1002 DAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKM 1066
            ||||||||||:|||..||||:||:|||||:||.:|||.|||:::|:||||:|||...||||||||
Mouse   921 DAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKM 985

  Fly  1067 PRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE 1131
            |||||||||||||||||||||||:||:|..||..|:||..|....||.|.|||||::.||||.||
Mouse   986 PRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050

  Fly  1132  1131
            Mouse  1051  1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_650505.2	PBP1_NPR-like	87..493	CDD:380596	127/441 (29%)
		PK_GC-A_B	589..883	CDD:270944	142/299 (47%)
		HNOBA	<890..938	CDD:462234	36/47 (77%)
		CYCc	917..1108	CDD:214485	144/190 (76%)
Npr1	NP_032753.5	PBP1_NPR_A	32..439	CDD:380608	126/431 (29%)
		PK_GC-A_B	530..803	CDD:270944	138/291 (47%)
		HNOBA	<809..857	CDD:462234	36/47 (77%)
		CYCc	836..1025	CDD:214485	144/188 (77%)