DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and gcy-22

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_508018.2	Gene:	gcy-22 / 180365	WormBaseID:	WBGene00001547	Length:	1058	Species:	Caenorhabditis elegans

Alignment Length:	1016	Identity:	339/1016 - (33%)
Similarity:	520/1016 - (51%)	Gaps:	119/1016 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 NAVFGLPC---EYVLAPISRYAD----VWQVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNNLG 218
            :.|.|.||   ..|...:::|.|    :|..|..::..|..|       |.|:.....:.:....
Worm    99 HVVLGPPCVRPAQVAGSVAKYLDFPLILWGPPFDSSLLNQFE-------YPTIASTTSSTLYQAT 156

  Fly   219 NVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLCLAAIHD---TIEEHSVYQLGF--DTSTWTK 278
            :::| :|..:.||..||||.     |..:.:...|...|.|   .:..:....:.:  ..|..|.
Worm   157 SLIR-LLEYYKWTEIALIYY-----VARSDLIPRCTPLISDFEGLVNNNDNLTITYRRQMSVITN 215

  Fly   279 ADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYD 343
            ......|:|:...:|:||:|.:....|:.::.:...|.:|..|||:|..|  ||.....|..|
Worm   216 TSYATALRNLKELARVVIVCLESDEARRNLMISISENGMDGDEYVYIMAE--SRRAGFASSFW-- 276

  Fly   344 KNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFS-----DNEPISAFV 403
             |.||..|:.|.:|....|.:..::.||.  |....|::|..:..   .||     :.:|..:.|
Worm   277 -NGTDGKNDLALRAARKFLVMDNQKYNDT--TTFVQEVRAAFSRP---PFSCPNCTNIDPTVSQV 335

  Fly   404 TSFFDGVLLYANALNESI---REDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAY 465
            ....|.:||||.|||.||   ..:||       ||:.........|.|.||.|.|:.|..|...:
Worm   336 GPLGDALLLYAYALNRSIATGNPNPT-------GTEFCEVAKGMEFLGFTGKVIINQNSTRTPLF 393

  Fly   466 SLLDMNPTTGRFEI-------------VAHFLHNRLEFEANKEIHWAGDREEAPPDRPICGYDGA 517
            .:.:::.|.....:             ||..::..:...|.....|.......|...||||:.|.
Worm   394 VVYNLDSTDKEMIVMQITEDLDDSKDPVASSVNYYITLVATPAQIWDTWGGTVPLSTPICGFTGT 458

  Fly   518 LCPDNSLPGYAILSIVLG----TMVVVMAV--CFFFGYRHYIAEAEINSMSWKVSLEDVMFRDAA 576
            .||.:....|  |:|:||    .:|:::||  ...|..|....|.|..:..|:|.     |....
Worm   459 DCPKSFTDQY--LAIILGCTAAALVLIIAVISTIVFLVRSKRQEEERLNQLWQVH-----FSSLV 516

  Fly   577 ERGLRGSFHSLVKQSSQLTLMSEDMVSING----DRQIFIPVGMFRKSKVAIKPVEVDNVQGLLT 637
            :...:.:.||  .:|.|.|:.:...|:||.    :|..|..:.  ..|.||.|    .|.:...|
Worm   517 KPPQKNTMHS--SRSLQSTVTTSTKVTINSKKDTERHSFYFLN--NDSVVARK----HNFRATFT 573

  Fly   638 RSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHD 702
            ::.....::|:::.:|:|.||.|..||......:..||.:|||||::.....|:||.|:.|||.|
Worm   574 KNDRAMFRKMRNVDNDNLCKFIGLSLDSPTLISIWRYCSRGSLQDVIAKGSLQMDWFFKYSLMRD 638

  Fly   703 IVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKL 767
            :...:.:||.|.|..||.|.||.|:||.|:.:|::.|||..:::.....:.|            .
Worm   639 VADAIYYLHHSPIGPHGWLSSSTCLVDERWQVKVSFFGLSAIKQYEVKEQRD------------F 691

  Fly   768 LWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPH 832
            |.||||.:| :.|.|.  |::.|:|:|.||..|:.|::..:.|     |....:|.|||     :
Worm   692 LHTAPEHIR-DTNLPI--TKEMDIYSFAIICSELITKKSAWDL-----ENETFDIEELV-----Y 743

  Fly   833 RMQK----PFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNL 893
            :::|    |.||.||...:....::.::|.||.|:|.:||....:|::::..| .|.:.|::|::
Worm   744 KIKKGGRSPPRPSLETEDEHNGSMSLLVRDCWNENPDQRPTSEQIKTLMKSMN-HNRSSNLMDHV 807

  Fly   894 LKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSD 958
            ...:|.||:|||:.|:.|.::..||||:.:.|||::||:.||.:|..||.|..||||.|||:|||
Worm   808 FNVLEQYASNLEDEVQARMKELTEEKKRSDVLLYRMLPKQVAEKLKLGQSVEPETFDCVTIFFSD 872

  Fly   959 IVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIA 1023
            :|.||.:::..||:|||..||||||.||:|:|..||||||||||.|:.|||||.||||:||:||:
Worm   873 VVSFTTLASRCTPLQVVNLLNDLYTTFDAIIEQHDVYKVETIGDGYLCVSGLPHRNGNEHAKEIS 937

  Fly  1024 RLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEA 1088
            .::.:||:|:..||:.|.|::|:.:|:|||||..|.||||:.|||||||||:|||||||||||:.
Worm   938 SMSFSLLKAIKTFRVPHLPKERINIRVGLHTGPVVTGVVGMTMPRYCLFGDSVNTASRMESNGKP 1002

  Fly  1089 LKIHIS-ETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWL 1128
            .::||| |..|...:..|.:.|..||.|.:||||.:.|:||
Worm  1003 GRVHISTECMKFLTEVIGGYQTEPRGEVIVKGKGAVQTHWL 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	87/369 (24%)
		ANF_receptor	108..473	CDD:279440	83/331 (25%)
		PK_GC-A_B	589..883	CDD:270944	92/301 (31%)
		Pkinase_Tyr	613..877	CDD:285015	83/267 (31%)
		HNOBA	<893..938	CDD:285003	19/44 (43%)
		CYCc	917..1108	CDD:214485	112/191 (59%)
		Guanylate_cyc	944..1130	CDD:278633	109/186 (59%)
gcy-22	NP_508018.2	Periplasmic_Binding_Protein_Type_1	28..408	CDD:299141	84/338 (25%)
		ANF_receptor	48..399	CDD:279440	83/329 (25%)
		PKc_like	553..795	CDD:304357	84/272 (31%)
		HNOBA	<791..852	CDD:285003	23/61 (38%)
		CYCc	831..1023	CDD:214485	112/191 (59%)
		Guanylate_cyc	858..1044	CDD:278633	109/186 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7809
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020