DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and gcy-32

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_506452.5	Gene:	gcy-32 / 179887	WormBaseID:	WBGene00001552	Length:	684	Species:	Caenorhabditis elegans

Alignment Length:	624	Identity:	157/624 - (25%)
Similarity:	260/624 - (41%)	Gaps:	130/624 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   636 LTRSLMLELKRMKD----LQH--DHLVKFYGA--------CLDQRRSFLLTEY---------CPK 677
            |.||:...||...|    |.:  ||:|  |.|        |.:.....||..|         ..|
Worm    86 LVRSMSPNLKGFLDNLDSLHYFIDHVV--YKANLRGPSFRCEETPDGTLLLHYFTGRPGLYHIVK 148

  Fly   678 GSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSH----------------GN----LK 722
            |.::::.: ..|.||  ..|.:.....|.:...:...:..|                |:    |.
Worm   149 GVVKEVAK-RVFDLD--ITLVVQGRTQRSVHMNNGERVEEHVVFLINNLSEPRRDSEGSEVSLLT 210

  Fly   723 SSNC----VVDSRFVLKITDFG----LHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRV-E 778
            |:|.    :||....:.:.||.    .|.:......|...|...::|.. ::||.....:||: |
Worm   211 STNANFPTIVDDTLGISLDDFSKALPYHFVIDESCKLVQCGSELHNHIP-NELLQPGTPILRIFE 274

  Fly   779 HNRPPEGTQKGDVYAFGIIVHEITTRQGPF---YLGRCAYEKSPQEI--------IELVKGYNPH 832
            .|||.......::..|...|..:..:..|.   ::...:.|:..||:        .||.:|::
Worm   275 INRPQIPLDFENICNFINAVFVLQVKTSPLKKKHMDAMSQEELKQEMETLDEDATNELTQGHH-- 337

  Fly   833 RMQKPFRPELEPNGDTK--ADINGIIRRCWAEDPAERPDFNTLKSMIR------RFNKDNETGNI 889
                     |:..|...  |....||..|       .|...::..:::      .....:.|.::
Worm   338 ---------LKLKGQMMLLASKKHIIYLC-------SPYVTSINELMQYGMRLTAMPLHDATRDL 386

  Fly   890 VDNLLKR---------MELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVV 945
            :  ||.:         ::|.|||  |.:|..|::...|::|.:.:|..:||:.:|.||:||:.:.
Worm   387 I--LLNQQRLSDVEVNLQLEANN--EQLETMTRELELERQKTDSILKDMLPRRIAQQLLSGEHIE 447

  Fly   946 AETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGL 1010
            | ...:.|:.|.|:..|.....:.:|..:|..||:::...|.||....||||||:.|:||.|||:
Worm   448 A-CEHEATVMFCDLPAFQQAIPQCSPKDIVNMLNEIFRKLDRIVVIRGVYKVETVSDSYMAVSGI 511

  Fly  1011 PIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDT 1075
            |... .:||..:..:||.::....:. |....:....||||:|:|...|||||...|:|||||:|
Worm   512 PDYT-PEHAENMCHVALGMMWEARSV-IDPVSKTPFLLRIGIHSGTITAGVVGTVHPKYCLFGET 574

  Fly  1076 VNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGEVPRP----- 1135
            |..||:|||.|.|.||..|:...:...|.|.|..:.||.:.:|.:|...||:|...:.:.
Worm   575 VTLASQMESLGMAGKIQCSKWAYQKAMETGRFEFSPRGRIDVKQRGLTETYFLTRSLKKSIWEII 639

  Fly  1136 --------NSLISPSKL------MLTRRSSLKQPQRSQS 1160
                    ||:....:|      .:|.:|:|.:|.:..|
Worm   640 DHDRDINVNSIEGYEELETAIENAVTIKSALPRPDQRNS 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944	60/317 (19%)
		Pkinase_Tyr	613..877	CDD:285015	60/305 (20%)
		HNOBA	<893..938	CDD:285003	15/53 (28%)
		CYCc	917..1108	CDD:214485	71/190 (37%)
		Guanylate_cyc	944..1130	CDD:278633	69/185 (37%)
gcy-32	NP_506452.5	HNOB	3..167	CDD:285002	22/85 (26%)
		HNOBA	226..440	CDD:285003	46/236 (19%)
		CYCc	419..608	CDD:214485	72/191 (38%)
		Guanylate_cyc	452..627	CDD:278633	67/176 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810