DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and daf-11

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_505960.3	Gene:	daf-11 / 179605	WormBaseID:	WBGene00000907	Length:	1077	Species:	Caenorhabditis elegans

Alignment Length:	1171	Identity:	283/1171 - (24%)
Similarity:	506/1171 - (43%)	Gaps:	258/1171 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 CSSKYGPIGFFEIYTQWPEVNAVFGLPCEYVLAPISRYADVWQVPVLTTGGNAKEFNKKSESYST 205
            |||.:..........|..|:|.:.|.|.|                                 :.|
Worm     5 CSSNFLRFANLTAEMQSLEINILKGYPYE---------------------------------HPT 36

  Fly   206 LTRLKGAQVNNLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCF----LCLAAIHDTIEEHSV 266
            :..:......||...:.::|..|.|.:...:...|         |:    |.......|||:.
Worm    37 MIDMVTRSPQNLAQNLVSLLRGFEWGQVGAVLCEE---------CYEGDELASEIYFSTIEDI-- 90

  Fly   267 YQLGFDTSTWTKADITRMLK---NVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIE 328
                |:.:.....:..|:.|   :|.:...|.|.  :| |.|.|:|              |:..:
Worm    91 ----FENNNIALKETVRIGKRENSVNISDAITIF--EP-SARVILL--------------FLGNK 134

  Fly   329 LFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAA--EK--- 388
            |....:::|:.        .:||...:: ||.::.::   .|..|.|....|..|||.  :|
Worm   135 LNDYTEFMTAM--------SMNNYTTEE-YTPVIVIS---KNSLELTFPWKENDAIAELFDKAII 187

  Fly   389 -YNYTFSDNEPISAFVTSF--------------FDGVLLYANALNESIREDPTMLTRPINGTDMV 438
             ||..: |...||:|::|:              ::|..|....|..:|..     |...|.....
Worm   188 VYNNCY-DKSKISSFLSSYSFSTIEETIISLQMYEGYHLLGYYLYTAITN-----TTLFNYVQPE 246

  Fly   439 RRMWNRSFTGITGNVTIDANGDRLSAYSLL--DMNPTTGRF---------------EIVAHF-LH 485
            :.:.:.|..|..|.:.|::||.|::.|.:|  |.:..:..|               :...:| |:
Worm   247 KAISSMSIPGPFGEIFINSNGQRIAGYDVLVVDKSLNSNNFIMPLGTISTDKKCPDQACLNFVLN 311

  Fly   486 NRLEFEANKEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYR 550
            :...||..|::             |:||:.|.:|....:  ...:::::|  |::|.:......|
Worm   312 STSSFEPLKDV-------------PLCGFHGEICDQTGV--IIAIAVIMG--VLLMFIIILTTIR 359

  Fly   551 HYIAEAEINSMS--WKVSLEDVMFRDAAERGLRGSFHSLV---------KQSSQLTLMSEDMVSI 604
            .....::..|:|  |.:..:||.|.|..  ...||.|..:         ||..|....::.:.::
Worm   360 KCCNGSKGRSISNPWVIPFQDVRFIDLT--NTEGSQHMSIQSLQRNMEEKQRLQSLARTKHIATV 422

  Fly   605 NGDRQIFIPVGMF-RKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQ-RR 667
            :   |:::....: .:.|:....:::         :|:.::|  ..||||:|..|.|..:|: ..
Worm   423 D---QVYVLADKYVMRDKLRYDKIDI---------NLLYQMK--SHLQHDNLNSFVGITIDKASH 473

  Fly   668 SFLLTEYCPKGSLQDILENEQFQLDWMFRLS--LMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDS 730
            .:::...|.:|||.|.:..::.|.....|..  .:.||::|::::|:|.|..||||...||::||
Worm   474 MYIIWNQCFRGSLHDHIFTKERQRGTATRFEGLFLRDILKGLEYIHASAIDFHGNLTLHNCMLDS 538

  Fly   731 RFVLKITDFGLHTLR---RTRFDLESDGGNCNSHAYWSK---LLWTAPELLRVEHNR-------- 781
            .:::|::.||::.|.   :|...:.::     .|....|   |.:..|.:.::..|.
Worm   539 HWIVKLSGFGVNRLLVKWKTSGQIFTE-----DHTPVIKSEELHYFDPAMKKIWKNYADRNERAL 598

  Fly   782 -PPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEK---SPQEIIE--LVKGYNPHRMQKPFRP 840
             .|:..:|.|:|:||:|:|||       .|.:...|:   ||:|..:  |:...|.....:...|
Worm   599 ITPQFGKKCDMYSFGVILHEI-------ILKKKFVEQLFDSPREEDDSVLIDDENDAIASRFPLP 656

  Fly   841 ELEPNG-DTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNL 904
            .:.|.| :...|:..::..|:.   :.|||....:.:|....|  .:|::||.::|.:..|...|
Worm   657 IIIPEGIEMHNDLIKMLENCFG---SVRPDIALARKIIDTVLK--MSGSLVDLMIKNLTAYTQGL 716

  Fly   905 EELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAES 969
            .|.|:.||.:..:|::|.::||.:|||:|||..|.:|..|..:.::..||.:|||||||::.::|
Worm   717 NETVKNRTAELEKEQEKGDQLLMELLPKSVANDLKNGIAVDPKVYENATILYSDIVGFTSLCSQS 781

  Fly   970 TPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVH 1034
            .||:||..|:.:|..||.|:.....||:|||||||.|.:|||:.....|.:.|..:||...:.:|
Worm   782 QPMEVVTLLSGMYQRFDLIISQQGGYKMETIGDAYCVAAGLPVVMEKDHVKSICMIALLQRDCLH 846

  Fly  1035 NFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKE 1099
            :|.|.|||...|..|.|.::|...|||:|.|.|||..||:.|..||:|||:|...:|.::..:::
Worm   847 HFEIPHRPGTFLNCRWGFNSGPVFAGVIGQKAPRYACFGEAVILASKMESSGVEDRIQMTLASQQ 911

  Fly  1100 ALDE-FGTFVTTRRGFVPMKGKGEMLTYWLE----------------------------GEV--- 1132
            .|:| |..||.:.||...::|.|.:||||||                            ||:
Worm   912 LLEENFPQFVCSNRGGRTIEGIGRILTYWLEGVNAGEQVKVVEFQNDLNDELSRIMKKDGELLAA 976

  Fly  1133 -----PRPNSLISPSKLMLTRRSSLKQPQRSQS-------HNLHKQYSELVVASPPPQLPPPAIA 1185
                 |:....::..|::..|::..::.||.|:       |....:.:|::|.....:..|..:.
Worm   977 ATALKPKDKMTLAKEKVIAERKNEEERLQRQQTLQEALEEHEEEIEMNEVLVDEDEGEGKPKEVD 1041

  Fly  1186 L 1186
            |
Worm  1042 L 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	76/401 (19%)
		ANF_receptor	108..473	CDD:279440	70/360 (19%)
		PK_GC-A_B	589..883	CDD:270944	72/318 (23%)
		Pkinase_Tyr	613..877	CDD:285015	67/288 (23%)
		HNOBA	<893..938	CDD:285003	17/44 (39%)
		CYCc	917..1108	CDD:214485	80/191 (42%)
		Guanylate_cyc	944..1130	CDD:278633	80/214 (37%)
daf-11	NP_505960.3	Periplasmic_Binding_Protein_Type_1	<33..295	CDD:299141	63/344 (18%)
		PKc_like	447..695	CDD:304357	67/264 (25%)
		HNOBA	<714..750	CDD:285003	15/35 (43%)
		CYCc	729..922	CDD:214485	81/192 (42%)
		Guanylate_cyc	756..943	CDD:278633	79/186 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910