DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and gcy-7

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_001360539.1	Gene:	gcy-7 / 179222	WormBaseID:	WBGene00001534	Length:	1117	Species:	Caenorhabditis elegans

Alignment Length:	1217	Identity:	387/1217 - (31%)
Similarity:	598/1217 - (49%)	Gaps:	165/1217 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PQAGQGLSLLLILCLLQAHLFPSAAWFYDAESVGGVASIGVGSDEHSFKTPETKNSHKSQSTELV 66
            |.....|.|.|::.||...:||..|    ..:.|.|..:|.              .|       .
Worm     3 PFYSMSLVLFLVITLLPKPMFPQVA----TGTTGNVIRVGF--------------IH-------C 42

  Fly    67 QHFPSLPMPDHRRLGARRQLVFVALLPSVESDNKNDCIMPKVLPVLELAIRHVQRMGFVGGSHFD 131
            :.|.|.|:....|..|                           ....:|:..::|...:.|..|:
Worm    43 RDFQSAPITVGYRTSA---------------------------AAASIAVDRLKRENLMSGWEFN 80

  Fly   132 IQLISRDTFCSSKYG-PIGFFEIYTQWPEVNAVFGLPC--EYVLAP--ISRYADVWQVPVLTTG- 190
            ..:...|...|...| .:...|.:    .|:.:.| |.  :..||.  :|.|   :..|::..|
Worm    81 FTIEFDDCVESEAAGMTVDLIEKH----NVDVIIG-PTMNQPTLAAFIVSNY---FNRPIIAWGL 137

  Fly   191 GNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLCLA 255
            .||.:.: ..|.:.....|...| .:||..:||:|..:.|::....|..|....|       |:.
Worm   138 VNAAQLD-DFERFPNAGILSAGQ-RSLGVAIRAVLKRYEWSQFVYAYFTEEDTEK-------CVT 193

  Fly   256 AIHDTIEEHSVYQ---LGFDTSTWTKADIT-----RMLKNVAMQSRIVIMC-ADPQSI-RQIMLT 310
            ..:|..:..|.:.   |.:....   |||:     ..||.:..:.||::.| .|...: |:.:|.
Worm   194 MRNDLQQVVSYFGDIILAYSIQV---ADISNDGMIEALKKIQSRGRIIVTCMKDGIGLRRKWLLA 255

  Fly   311 AEELNMIDSGEYVFINIELFSRVQYLT------SQP-WYDKNDTDLNNERAQKAYTAMLTVTPKQ 368
            |||..|| ..|||::..::.|: .|:.      .:| |.....:|.|:.||.||:...:.:....
Worm   256 AEEAGMI-GDEYVYVFSDIKSK-GYVVPLLGGGERPSWILSTGSDENDTRALKAFKQSIFICDMM 318

  Fly   369 PNDN---EYTRVSNEIKAIAAEKYNYTFSD----NEPISA-FVTSFFDGVLLYANALNESIREDP 425
            ...:   .||....||.|...|...:...|    |..::| :.....|.|..|..||::.::...
Worm   319 GQGSIATNYTIFGQEIIARMKEAPYFCTKDCEGENFTVAATYAGQLHDAVYAYGVALDKMLKAGQ 383

  Fly   426 TMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHN-RLE 489
            ....|  |.|..: |.:.:||.|::|||||:..|.|.....||.::.......:...::.| ...
Worm   384 IAQYR--NATAFM-RYFPQSFIGMSGNVTINEKGTRNPTLFLLALDENNNNTRMATIYVENMSAT 445

  Fly   490 FEA---NKEIHWAGDREEA-PPDRPICGYDGALCPDNSLPGY---AILSIVLGTMVVVMAVC-FF 546
            |.|   ::.:.||..:..| |.|.|:||:.|.|||.:.:..|   .|::||:..:.:..|.| .:
Worm   446 FNALYSDEGVMWASRKNNARPVDVPLCGFTGNLCPKSFVDEYLIWVIVAIVVLFLAITAAACGIY 510

  Fly   547 FGYRHYIAEAEINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQSSQLTLMSEDMVSINGDRQIF 611
            |..:....|.|..:..|::....:...::.::| :|.......||...||.|...||...:.:.|
Worm   511 FSIQARRQEIERLNRLWQIPFIHLHQINSKQKG-KGEHSVRSLQSGTSTLSSRTTVSFKTESRNF 574

  Fly   612 IPVGMFRKS--------KVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRS 668
            :...:.|:|        |.|.:| .:|:.:....|||       ::|..|:|.:|.|.|||..:.
Worm   575 LFFSLQRESDYEPVVAKKHAYRP-RLDDDKCTFMRSL-------RNLDQDNLNRFIGLCLDGPQM 631

  Fly   669 FLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFV 733
            ..:..:|.:||:.|::.....|:|..|..||:.|:|.|:.|||.|.:..||.|.|..|::|.|:.
Worm   632 LSVWRFCSRGSIADVILKATIQMDNFFIYSLIKDMVHGLVFLHGSMVGYHGMLTSKCCLIDDRWQ 696

  Fly   734 LKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIV 798
            :||:::||..||......:.|            |||:||||||.|..:   |:::||||:.|||.
Worm   697 VKISNYGLQDLRSPEMYEKKD------------LLWSAPELLRAEDIK---GSKEGDVYSLGIIC 746

  Fly   799 HEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADIN----GIIRRC 859
            .|:.||:|.|.:.  ..::.|:|||.|:|   ...::.| ||:||  .|...:||    .::|.|
Worm   747 AELITRKGVFNME--DRKEDPEEIIYLLK---KGGLKSP-RPDLE--YDHTIEINPALLHLVRDC 803

  Fly   860 WAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEK 924
            :.|.|:|||...|::|.:|..| .:...|::|::...:|.||::|||.|.|||::..|||||.:.
Worm   804 FTERPSERPSIETVRSQLRGMN-SSRNDNLMDHVFNMLESYASSLEEEVSERTKELVEEKKKSDV 867

  Fly   925 LLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIV 989
            |||::||::||.:|..||.|..|||:||||:|||:|.||.::::.||:|||..||||||.||.|:
Worm   868 LLYRMLPKTVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLASKCTPLQVVNLLNDLYTIFDGII 932

  Fly   990 ENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHT 1054
            |..||||||||||.|:.|||||.||||:|.|:||.::||.|.::..||:.|.|.:|:.||||::.
Worm   933 EKHDVYKVETIGDGYLCVSGLPHRNGNEHVRQIALMSLAFLSSLQFFRVPHLPSERINLRIGMNC 997

  Fly  1055 GACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKG 1119
            |:.|||||||.|||:|||||.|||||||||||:..|||:|......|...|.|.|..||.|.:||
Worm   998 GSVVAGVVGLTMPRFCLFGDAVNTASRMESNGKPGKIHVSAEANRMLHLVGGFDTESRGEVIIKG 1062

  Fly  1120 KGEMLTYWLEGEVPRPNSLISPSKLMLTRRSSLKQPQRSQSHNLHKQ 1166
            ||.|.|:||.|:   ....:|.::.:..::.|.|..:..|...:|:|
Worm  1063 KGVMETFWLTGQ---GTGAVSGARHVSAKKVSKKMYEEFQMDEIHRQ 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	97/444 (22%)
		ANF_receptor	108..473	CDD:279440	94/395 (24%)
		PK_GC-A_B	589..883	CDD:270944	103/305 (34%)
		Pkinase_Tyr	613..877	CDD:285015	93/275 (34%)
		HNOBA	<893..938	CDD:285003	22/44 (50%)
		CYCc	917..1108	CDD:214485	113/190 (59%)
		Guanylate_cyc	944..1130	CDD:278633	111/185 (60%)
gcy-7	NP_001360539.1	PBP1_NPR_GC-like	36..438	CDD:380575	101/474 (21%)
		PKc_like	550..822	CDD:389743	101/302 (33%)
		CYCc	860..1049	CDD:214485	112/188 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7809
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020