DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and gcy-18

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_502449.2	Gene:	gcy-18 / 178237	WormBaseID:	WBGene00001543	Length:	1113	Species:	Caenorhabditis elegans

Alignment Length:	1166	Identity:	344/1166 - (29%)
Similarity:	543/1166 - (46%)	Gaps:	175/1166 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PETK-NSHKSQSTELVQHFPSLPMPDHRRLGARRQLVFVALLPSVESDNKNDCIMPKVLPVLELA 115
            |:.| |..||..|:...........:|:|      ::.:..:.:|.       :||....:|.::
Worm    23 PDIKENGEKSSYTQFDNGAKLEVNKEHKR------VIKIGHIGAVG-------VMPNDARILNIS 74

  Fly   116 IRHVQRMGFVGGSHFDIQLISRDTFCSSKYGPIGFFEIYTQWPEVNAVFGLPCEYVLAPISRYAD 180
            ..::...|.| |...:.:::||.....|..|.....|:| ...:|.|..|..|...|..:::.|.
Worm    75 KENLIEEGLV-GDDIEFEIVSRQACSESFEGVAVAAELY-HVHQVRAFIGPYCAAELEAVTKMAT 137

  Fly   181 VWQVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTALIYQNENAKVK 245
            .|.:|:::........:.:| .|.||.|:.....|::.....|:|..:.|.:.|:       ...
Worm   138 FWNIPIISYSSVPNAVSDRS-VYKTLARVSSKNTNSIAEATVALLLHYKWLKVAI-------ATN 194

  Fly   246 GNSVCFLCLAAIHDTIEEHS---VYQLGFDTSTWTKADITRM-----LKNVAMQSRIVI-MCADP 301
            ..|..|..::...:.:....   |.::.||.:|    |...|     |.::|..:||:| :.:..
Worm   195 TGSTAFERVSIFEEIMHREGVTIVKKVMFDENT----DANEMMNSGQLGDLAANARIIICLFSST 255

  Fly   302 QSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTP 366
            :.:.:..:.|.....:::.||.:|...|.|..:.||  ||...:...|  :|.:..|...:.|..
Worm   256 KELSKEFMQATYTMRMNNAEYAYIIPWLQSGTKDLT--PWIGADGEML--QRVKDHYANAIIVDD 316

  Fly   367 KQPNDNEYTRVSNEIKAIAAEKYNYTFSDNE--PISAFVTSFFDGVLLYANALNESIRE--DPTM 427
            ....|:..  ||:.::.|  ||:....||.:  .|:.:: ..||.:.|||.|:.:.:.|  :...
Worm   317 VNGFDDSV--VSSFVEKI--EKHGMQKSDIDVTNINGYL-HLFDSLKLYALAIRKVLNETDNEAY 376

  Fly   428 LTRPINGTDMVRRMWNRSFTGIT--------------GNVTIDANGDRLSAYSLLDMNPTTGRF- 477
            :|   ||..:..||....|.|:.              |.|.:|...||...:|...::|...:.
Worm   377 VT---NGQFIWNRMRRMKFEGVVSRSSSEENKDAGAIGTVLMDDVADRAPIFSAFYISPNRDKVM 438

  Fly   478 -------EIVAHF--LHNR-----LEFEANKEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYA 528
                   |::::.  |.|:     |:....|...|..:....|.|.|||||.|..|      .|
Worm   439 KMVNMESELISNCDGLKNKSGCFQLKINDIKSGFWPSEDGSMPLDEPICGYRGQRC------SY- 496

  Fly   529 ILSIVLGTMVVVM---AVCFFFGYRHYIAEAEINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQ 590
            :|.|.:|::::::   :|.|||.:| |....::..|.|::..:|:.|.|..:      ..|::..
Worm   497 LLEISVGSLIILLILISVVFFFLFR-YCENKQLEKMPWRIFHDDLQFIDEEQ------VKSMMSV 554

  Fly   591 SSQLTLMSEDMVSINGDRQIFIPVGMFR-------KSKVAIKPVEVDNVQGLLTRSLMLELKRMK 648
            .|..|.:|...   .|.:|..| :|:..       |.:..||.::.|          |..|.:||
Worm   555 GSVTTKLSNIQ---TGQKQHAI-IGVNTHTTYHRYKQRRPIKFIKED----------MQLLTQMK 605

  Fly   649 DLQHDHLVKFYGACLDQRRSFL-LTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHS 712
            ...||:|..|.||..:::...| |.::|.:|::|||:.|....||..|..:.:.||..|:::||:
Worm   606 QAVHDNLNPFLGAAFNEKEEMLVLWKFCSRGTIQDIIYNANVVLDEKFHGAFVRDITLGLEYLHA 670

  Fly   713 SDIRSHGNLKSSNCVVDSRFVLKITDFGL-HTLRRTRFD--------LESDGGNCNSHAYWSKLL 768
            |.|..||:|....|::|..:::|::|:|: :.|.|....        .:||..:..|.|  :.::
Worm   671 SPIGYHGSLTPWCCLIDRNWMVKLSDYGIANPLERWEKQGAIEIAAAKDSDDKSQASQA--TSII 733

  Fly   769 WTAPELLRVEHNRPPEG------------TQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQE 821
            :.|||||:........|            .|.||:|:||::::||..|..||        :....
Worm   734 YMAPELLKNRETNKRRGMDQSWVKQSMLRRQAGDIYSFGMVMYEILFRSLPF--------RDNTN 790

  Fly   822 IIELV----KGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNK 882
            |.|||    .|      .|...||::.......|:|.::|.||:|:|..||.       |||...
Worm   791 ISELVDYLADG------SKTVSPEIQNQMGLHPDLNALLRDCWSENPEIRPS-------IRRVRL 842

  Fly   883 DNE-----TGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQ 942
            :.|     .|::||.::|.||.||||||:||.|||....|...:.::||.||||..||.:|..|:
Worm   843 NTEMVLKTKGSLVDQMMKMMEQYANNLEKLVAERTGMLEEANIRADQLLTQLLPAYVANELKMGR 907

  Fly   943 PVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVV 1007
            .|..:.:...||.||||||||.|.:.|||::||..||.|||.||..:.....|||||||||||||
Worm   908 SVAPKLYSSATILFSDIVGFTTICSGSTPLEVVNMLNGLYTGFDECITRNKSYKVETIGDAYMVV 972

  Fly  1008 SGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLF 1072
            ||:|..|...|:|.||..||.:.:.:..::|.|||..|::.|.|.|||:..||||||..||||||
Worm   973 SGIPEENEYNHSRNIANTALDMRQYLTGYQIPHRPTHRVRCRWGFHTGSVAAGVVGLTCPRYCLF 1037

  Fly  1073 GDTVNTASRMESNGEALKIHISETTKEAL-DEFGTFVTTRRGFVPMKGKGEMLTYWLEGEV 1132
            |||||.:|||||.|....|.:||.....: .....|.||.||.|.:||||...|:|||..|
Worm  1038 GDTVNVSSRMESTGTPGMIQMSEEAHMHIRAHHPVFTTTERGEVQVKGKGTCRTFWLEDRV 1098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	93/451 (21%)
		ANF_receptor	108..473	CDD:279440	84/391 (21%)
		PK_GC-A_B	589..883	CDD:270944	90/326 (28%)
		Pkinase_Tyr	613..877	CDD:285015	81/296 (27%)
		HNOBA	<893..938	CDD:285003	23/44 (52%)
		CYCc	917..1108	CDD:214485	94/191 (49%)
		Guanylate_cyc	944..1130	CDD:278633	96/186 (52%)
gcy-18	NP_502449.2	Periplasmic_Binding_Protein_Type_1	87..448	CDD:299141	82/385 (21%)
		ANF_receptor	87..395	CDD:279440	73/332 (22%)
		PKc_like	549..846	CDD:304357	91/333 (27%)
		HNOBA	<857..903	CDD:285003	23/45 (51%)
		CYCc	882..1073	CDD:214485	94/190 (49%)
		Guanylate_cyc	909..1095	CDD:278633	95/185 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910