Protein Alignment CG31183 and gcy-8

DIOPT Version :10

• Sequence 1: NP_650505.2
• Gene: CG31183 / 41927
• FlyBaseID: FBgn0051183
• Length: 1417
• Species: Drosophila melanogaster
• Sequence 2: NP_501324.2
• Gene: gcy-8 / 177584
• WormBaseID: WBGene00001535
• Length: 1152
• Species: Caenorhabditis elegans
• Alignment Length: 1139
• Identity: 331/1139 - (29%)
• Similarity: 532/1139 - (46%)
• Gaps: 194/1139 - (17%)

  Fly   100 KNDCIMPKVLPVLELAIRHVQRMGFVGGSHFDIQLISRDTFCSSKYGPIGFFEIYTQWPEVNAVF 164
            :||      :.:||::.:.:|..|.: ....|:::||: |.|...|..:..........:|.|..
 Worm    81 RND------VKILEVSHKALQAEGIL-DDDLDVEIISQ-TGCGESYEGVAVAADMYHLQKVKAFI 137

  Fly   165 GLPCEYVLAPISRYADVWQVPV---LTTGGNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILN 226
            |..|...:..::|.|..|.:|:   :....|..:.|    :|.||.|:.....|::.....|:|.
 Worm   138 GPYCNAEMDAVARMAAFWNIPIIGYMAASNNLADKN----AYPTLARISLRTTNSIAEATCAMLR 198

  Fly   227 SFNWTRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHS---VYQLGFDTSTWTKADITRMLKNV 288
            .:.|.:.|:|   .|..:    :.:..:.:..:...:..   |.::.||....:||.|...|.|.
 Worm   199 HYGWNKVAII---TNTGI----LAYDRVLSFEEVFHQRGINVVKKIMFDEFADSKAMIASGLLND 256

  Fly   289 AMQSRIVIMCA---DPQSIRQIMLTA--EELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTD 348
            ...|..:::|.   ..:|.|:.:..|  :.:|:.:.| |||               ||......|
 Worm   257 IKNSARIVVCLFSNTRESSREFLTAANTQGMNVNEYG-YVF---------------PWLQDGGKD 305

  Fly   349 LNN---------ERAQKAYTAMLTVTPKQPNDNEYT-----RVSN----EIKAIAAEKYNYTFSD 395
            .:.         ::.:..|...:.:......||...     |:.:    |.....|..|.|.:
 Worm   306 ASPWTGADGSMLQKVKDQYANAIIIDDVNSFDNTIVGPFIERIKDVGLTEADVDIANIYGYLY-- 368

  Fly   396 NEPISAFVTSFFDGVLLYANA----LNESIREDPTMLTRPINGTDMVRRMWNRSFTGI------- 449
                      .||.:.|||.|    |||:.:.:     ..:||..|.:.|....|.|:
 Worm   369 ----------LFDALKLYAIAARKVLNETGKAE-----NLLNGRMMWQNMRKLKFVGMVGASGIA 418

  Fly   450 TGNVTIDANGDRLSAY-------------SLLDMNPT-----------TGRFEIVAHFLHNRLEF 490
            :|.|::|...:|...|             .::.|.||           :|.:|||...:..  :|
 Worm   419 SGQVSMDDRAERAPLYRGFFVSPNSDSVLPMVHMEPTMLDNCDGIANKSGCYEIVVTDIMR--DF 481

  Fly   491 EANKEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAE 555
                   |.....:.|.|.|.|||....| |.:|   .|:...|..:.:|.||..||..: .:.:
 Worm   482 -------WPSVDRKMPKDEPDCGYRNERC-DYTL---IIIGAALILLFIVAAVSAFFAQK-ILEK 534

  Fly   556 AEINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQSSQLTLMSEDMVSIN-GDRQIFIPVG---- 615
            ..::.:.:::..:|:.|.|  |..|:    |::...|..|.||    ::| |.|...| ||
 Worm   535 RALDKLPFRIYRDDLQFID--EEQLK----SMLSLGSTRTKMS----NMNYGSRNHAI-VGTNTH 588

  Fly   616 -MFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLT-EYCPKG 678
             ::.| .|..:|:..:.....|       ::.||...||::..|.|...::|...||. ::|.:|
 Worm   589 AIYHK-YVQRRPIVFNRADKTL-------IQLMKAAVHDNINPFLGMVWNEREEMLLVWKFCSRG 645

  Fly   679 SLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGL-H 742
            :||||:.||..|||..|..:.:.||:.|:::||:|.|..||:|...:|::|..:::|:||:|: .
 Worm   646 TLQDIIYNESIQLDTKFHGAFIRDILAGLEYLHASQIGYHGSLTPWSCLIDRNWMIKLTDYGIAD 710

  Fly   743 TLRR-------TRFDLESDGGNCNSHAYWSKLLWTAPELLR-VEHNR-----------PPEGTQK 788
            .|.|       :|..|.||.....: ...:.:|:.:||:|: .|.||           .....|.
 Worm   711 PLERWEKSQSISRDGLTSDDDKSQA-TQATSILYESPEMLKNREKNRVRRVDQDWMRQTQTRRQL 774

  Fly   789 GDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADIN 853
            |||||||::::||..|..||..|     .:..|::|.::..:     |..:|.:..|.....|::
 Worm   775 GDVYAFGLVMYEIIFRALPFPEG-----TNQSELVEWLRDGS-----KVVKPTIPQNKVLNMDLS 829

  Fly   854 GIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEE 918
            .:|:.||...|..||....:|..:..:.  |..|::||.:.:.||.||||||:||.|||....|.
 Worm   830 ALIQDCWNTTPEMRPSLRRIKLNVETYL--NIKGSLVDQMTRMMEQYANNLEKLVAERTGMLEEA 892

  Fly   919 KKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYT 983
            .::.::||.||||..||.:|..|:||..:||...|:.||||||||.:...::|::||..||.::.
 Worm   893 NQRADRLLSQLLPAYVANELKLGRPVPPKTFTSSTVLFSDIVGFTEMCQNASPLEVVAVLNGIFD 957

  Fly   984 CFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKL 1048
            .||..:...|.|||||||||||||||:|..||::|..|||.:||.:.:.:..|.:.|:.:.:::.
 Worm   958 GFDQFIARKDAYKVETIGDAYMVVSGVPEENGHRHINEIASIALDVHKFLSEFIVPHKRDTKVQC 1022

  Fly  1049 RIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKE-ALDEFGTFVTTRR 1112
            |:|.|||...|.||||..|||||||||||.|||||||.|..|..||||.|. .|.|:..::..:|
 Worm  1023 RLGFHTGPVAAAVVGLNAPRYCLFGDTVNMASRMESNSEPGKTQISETAKNLLLKEYPDYICEQR 1087

  Fly  1113 GFVPMKGKGEMLTYWLEGEVP----RPNSLISPS 1142
            |.:|:||||..:||||.|...    |..:.::||
 Worm  1088 GEIPIKGKGLCMTYWLMGTKSEGSGRSGAYLAPS 1121

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_650505.2	PBP1_NPR-like	87..493	CDD:380596	90/456 (20%)
		PK_GC-A_B	589..883	CDD:270944	91/320 (28%)
		HNOBA	<890..938	CDD:462234	24/47 (51%)
		CYCc	917..1108	CDD:214485	95/191 (50%)
gcy-8	NP_501324.2	PBP1_NPR_GC-like	80..456	CDD:380575	84/426 (20%)
		Protein Kinases, catalytic domain	558..850	CDD:473864	91/319 (29%)
		CYCc	891..1084	CDD:214485	95/192 (49%)