DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and Gucy2e

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	XP_036012232.1	Gene:	Gucy2e / 14919	MGIID:	105123	Length:	1139	Species:	Mus musculus

Alignment Length:	1261	Identity:	384/1261 - (30%)
Similarity:	580/1261 - (45%)	Gaps:	253/1261 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 AAWFYDAESVGGVASIGVGSDEHSFKTPETKNSHKSQSTELVQHFPSLPMPDHRRLGARRQLVFV 89
            :||...|   ||:...|       |..| .:.|..|.|..|....|.||           .|:.:
Mouse     2 SAWLLPA---GGLPGAG-------FCVP-ARQSPSSFSRVLRWPRPGLP-----------GLLLL 44

  Fly    90 ALLPS-----------VESDNKNDCIMPKVLPVL--ELAIRHVQR-MGFVGGSHFDIQLISRDTF 140
            .||||           |......|.|..:..|.|  .||...:.| ....||..|::.|:.....
Mouse    45 LLLPSPSALSAVFKVGVLGPWACDPIFARARPDLAARLAANRLNRDFALDGGPRFEVALLPEPCL 109

  Fly   141 CSSKYGPIGFFEIYTQWPEVNAVFGL----------PCEYVLAPISRYADVWQVPVLTTGGNAKE 195
            .....|.:.        ..::.|.||          |.|.    :::.|.|..||....|
Mouse   110 TPGSLGAVS--------SALSRVSGLVGPVNPAACRPAEL----LAQEAGVALVPWGCPG----- 157

  Fly   196 FNKKSESYSTLTRLKGA---QVNNLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLCL--- 254
                       ||..|.   .|....:.:..:|.:|.|.|.|||...::..|:........|
Mouse   158 -----------TRAAGTTAPAVTPAADALYVLLRAFRWARVALITAPQDLWVEAGRALSTALRAR 211

  Fly   255 ---AAIHDTIEEHSVYQLGFDTSTWTKA-----DITRML-----------------------KNV 288
               .|:..::|..       |.|...:|     |..|:.                       .:|
Mouse   212 GLPVALVTSMETS-------DRSGAREALGRIRDGPRVRGKLPSRVRARWVGPAESGQRSEPASV 269

  Fly   289 AMQSRIVIMCADP-----QSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTD 348
            :::|.:|||....     :..|.::..||||.:.| |..||:.   |..:.|..| |..:.....
Mouse   270 SVRSAVVIMVMHSVLLGGEEQRYLLEAAEELALTD-GSLVFLP---FDTLHYALS-PGPEALAAF 329

  Fly   349 LNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDN-EPISAFVTSFFDGVLL 412
            :|:.:.::|:.|:||:|.:.|....   |.:.::. |.|........| :.:|....:.:|.|.|
Mouse   330 VNSSQLRRAHDAVLTLTRRCPPGGS---VQDSLRR-AQEHQELPLDLNLKQVSPLFGTIYDAVFL 390

  Fly   413 YANALNESIREDPTMLTRPINGTDMVRRMWN---RSFTGITGN--------VTIDANGDRLSAYS 466
            .|..:.   |....:....::|..:.|::..   ..|.|:.|.        :..||:|::|.|..
Mouse   391 LAGGVK---RARTAVGGGWVSGASVARQVREAQVSGFCGVLGRTEEPSFVLLDTDASGEQLFATH 452

  Fly   467 LLDMNPTTGRFEIVAHFLHNRLEFEANKEIHWAGDREEAPPDRPICGYD-GALCPDNSLPGYAIL 530
            |||  |..|...            .|...:|:........|| |.|.:| ..:|.....||...:
Mouse   453 LLD--PVLGSLR------------SAGTPMHFPRGGPAPGPD-PSCWFDPDVICNGGVEPGLVFV 502

  Fly   531 SIVLGTMVVVMAV--CFFFGY-RHYIAEAEINSMSWKV--SLEDVMF----RDAAERGLRGSFHS 586
            ..:|   |:.|.:  .|...| ||.:...::.|...|:  :||||.|    ..::.:.::||
Mouse   503 GFLL---VIGMGLTGAFLAHYLRHRLLHMQMASGPNKIILTLEDVTFLHPPGGSSRKVVQGS--- 561

  Fly   587 LVKQSSQLTLMSEDMVSINGDRQIFIPVGMFR-----------KSKVAIKPVEVDNVQGLLTRSL 640
               :||..|..:.|:.|:....|....||::.           :..:||:|.         |::
Mouse   562 ---RSSLATRSASDIRSVPSQPQESTNVGLYEGDWVWLKKFPGEHHMAIRPA---------TKT- 613

  Fly   641 MLELKRMKDLQHDHLVKFYGACL----DQRRS------FLLTEYCPKGSLQDILENEQFQLDWMF 695
              ...::::|:|:::..:.|..|    |...:      .:::|:|.:|||.|:|...:.:|||||
Mouse   614 --AFSKLRELRHENVALYLGLFLAGTADSPATPGEGILAVVSEHCARGSLHDLLAQREIKLDWMF 676

  Fly   696 RLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNS 760
            :.||:.|:::||::||...: :||.|||.|||||.|||||:||.|...|...:..|......
Mouse   677 KSSLLLDLIKGMRYLHHRGV-AHGRLKSRNCVVDGRFVLKVTDHGHGRLLEAQRVLPEPPSA--- 737

  Fly   761 HAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIEL 825
                ...||||||||| :.:....||..|||::..||:.|:..|..|:.:    .|.:|:|:|:.
Mouse   738 ----EDQLWTAPELLR-DPSLERRGTLAGDVFSLAIIMQEVVCRSTPYAM----LELTPEEVIQR 793

  Fly   826 VKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIV 890
            |:  :|..:.:|    |........:...::.:||||.|..||..:....:.:..||..:| ||:
Mouse   794 VR--SPPPLCRP----LVSMDQAPMECIQLMTQCWAEHPELRPSMDLTFDLFKSINKGRKT-NII 851

  Fly   891 DNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIY 955
            |::|:.:|.|::|||:|:.|||::..:||:|.::||.|:||.|||..|..|..|..|.|::||:|
Mouse   852 DSMLRMLEQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLY 916

  Fly   956 FSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAR 1020
            ||||||||.|||.|.|::||..||||||.||:|:...||||||||||||||.||||.|||.:||.
Mouse   917 FSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGAHDVYKVETIGDAYMVASGLPQRNGQRHAA 981

  Fly  1021 EIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESN 1085
            |||.::|.:|.||.:||:.|.||..:::|||||:|.||||||||.|||||||||||||||||||.
Mouse   982 EIANMSLDILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMEST 1046

  Fly  1086 GEALKIHISETT---KEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE------VPRPNSL--- 1138
            |...:||::.:|   ..|||:  .|....||...:||||...||||.|.      :|:|..|
Mouse  1047 GLPYRIHVNMSTVRILRALDQ--GFQMECRGRTELKGKGIEDTYWLVGRLGFNKPIPKPPDLQPG 1109

  Fly  1139 -----ISPSKLMLTRRSSLKQPQRSQ 1159
                 ||..::...||..|::.:..|
Mouse  1110 ASNHGISLQEIPPERRKKLEKARPGQ 1135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	98/487 (20%)
		ANF_receptor	108..473	CDD:279440	88/431 (20%)
		PK_GC-A_B	589..883	CDD:270944	91/314 (29%)
		Pkinase_Tyr	613..877	CDD:285015	84/284 (30%)
		HNOBA	<893..938	CDD:285003	21/44 (48%)
		CYCc	917..1108	CDD:214485	118/193 (61%)
		Guanylate_cyc	944..1130	CDD:278633	116/188 (62%)
Gucy2e	XP_036012232.1	PBP1_sensory_GC_DEF-like	58..465	CDD:380594	93/467 (20%)
		PK_GC-2D	570..845	CDD:270945	88/305 (29%)
		HNOBA	<854..899	CDD:400168	21/44 (48%)
		CYCc	879..1070	CDD:214485	118/192 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820