DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and Gucy2d

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_001124165.1	Gene:	Gucy2d / 14918	MGIID:	106030	Length:	1117	Species:	Mus musculus

Alignment Length:	1150	Identity:	368/1150 - (32%)
Similarity:	561/1150 - (48%)	Gaps:	211/1150 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 DC--IMPKVLPVL--ELAIRHV-QRMGFVGGSHFDIQLI--------SRDTFCSSK------YGP 147
            ||  |..:.||.:  :||:..| |....:.||..|.:::        :..||.:.|      .||
Mouse    79 DCDPIFAQALPSIATQLAVDQVNQDASLLPGSQLDFKVLPTGCDTPHALATFVAHKNIVAAFVGP 143

  Fly   148 I--GFFE----IYTQWPEVNAVFGLPCEYVLAPISRYADVWQVPVLTTGGNAKEFNKKSESYSTL 206
            :  ||..    :...|.:  ::|...||   ||              .||        .:...||
Mouse   144 VNPGFCSAAALLAQGWGK--SLFSWACE---AP--------------EGG--------GDLVPTL 181

  Fly   207 TRLKGAQVNNLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHSVYQLGF 271
            .        :..:|:.:::..|.|.|.|::..:::       :.......:......|.: .:|.
Mouse   182 P--------SAADVLLSVMRHFGWARWAIVSSHQD-------IWVTTAQQLATAFRTHGL-PIGL 230

  Fly   272 DTSTWT----KADITRMLKNVAMQSRIVIMCADPQSIRQIMLT-----AEELNMIDSGEYVFINI 327
            .||...    ..::.:.|.:| ...:||::|.....:..:..|     |.|..:.| |..||:..
Mouse   231 VTSLGPGEKGATEVCKQLHSV-HGLKIVVLCMHSALLGGLEQTTLLHCAWEEGLTD-GRLVFLPY 293

  Fly   328 ELFSRVQYLTSQPWYDKNDTDLNNE-RAQKAYTAMLTVT-PKQPNDNEYTRVSNEIKAIAAEKYN 390
            :..     |.:.|:.:::...|::. ..|:||.|:|||: ...|..:.:|         |.|...
Mouse   294 DTL-----LFALPYGNRSYLVLDDHGPLQEAYDAVLTVSLESSPESHAFT---------ATEMSG 344

  Fly   391 YTFSDNEP--ISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNV 453
            ...::.||  :|....:.:|.|:|.|:|||.|......:....:.  |.||.:   ...|.:..:
Mouse   345 GATANLEPEQVSPLFGTIYDAVILLAHALNRSETHGAGLSGAHLG--DHVRAL---DVAGFSQRI 404

  Fly   454 TIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHN---RLEFEANKEIHWAGDREEAPPDRPI-CGY 514
            ..|..|.||:.|.:||.: ..|...:..|.|..   ::: ...|.||:.|.   :||.... |.:
Mouse   405 RTDGKGRRLAQYVILDTD-GEGSQLVPTHILDTSTWQVQ-PLGKPIHFPGG---SPPAHDASCWF 464

  Fly   515 D-GALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKVSLEDVMFRDAAER 578
            | ..||.....|..::|::.:..::.::.     |:..|.....:..:                |
Mouse   465 DPNTLCIRGVQPLGSLLTLTIACVLALVG-----GFLAYFIRLGLQQL----------------R 508

  Fly   579 GLRGSFHSLVKQSSQLTLM--------------SEDMVSINGDRQIFIPVGMFRKSKVAIKPVEV 629
            .|||. |.::..|.:||.:              ||....::|.....:..|..|.....::...|
Mouse   509 LLRGP-HRILLTSQELTFLQRTPSRRRPHVDSGSESRSVVDGGSPRSVTQGSARSLPAFLEHTNV 572

  Fly   630 DNVQGL--------------LTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSL 680
            ...||.              |..|.:..|:::::::|:::..|.|..:....|.::.|:|.:|||
Mouse   573 ALYQGEWVWLKKFEAGVAPDLRPSSLSFLRKLREMRHENVTAFLGLFVGPGVSAMVLEHCARGSL 637

  Fly   681 QDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLR 745
            :|:|:||..:|||.|:.||:.|::||:::||.... .||.|||.|||||:||||||||.|....
Mouse   638 EDLLQNENLRLDWTFKASLLLDLIRGLRYLHHRRF-PHGRLKSRNCVVDTRFVLKITDHGYAEF- 700

  Fly   746 RTRFDLESDGGNCNSHAYWS--KLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPF 808
                 |||   :|:|....:  :||||||||||    .|.:.|.||||::..||:.|:.||..|:
Mouse   701 -----LES---HCSSRPQPAPEELLWTAPELLR----GPGKATFKGDVFSLAIILQEVLTRDPPY 753

  Fly   809 YLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTL 873
                |::..|.:|||..|....|     ..||.:.|:......|. :::.||.|.|.:||..:.:
Mouse   754 ----CSWGLSAEEIIRKVASPPP-----LCRPLVSPDQGPLECIQ-LMQLCWEEAPDDRPSLDQI 808

  Fly   874 KSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQL 938
            .:..:..|:..:| ::||::|:.:|.|:.:||:||:|||::...|::|.|:||.|:||.|||..|
Mouse   809 YTQFKSINQGKKT-SVVDSMLRMLEKYSESLEDLVQERTEELELERRKTERLLSQMLPPSVAHAL 872

  Fly   939 ISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDA 1003
            ..|..|..|.|||||||||||||||.|||.|.|::||.|||||||.||:::::.|||||||||||
Mouse   873 KMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTLFDAVLDSHDVYKVETIGDA 937

  Fly  1004 YMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPR 1068
            |||.||||.||||:||.|||.|||.:|....|||:.|.|:..:::|.|||:|.||||||||.|||
Mouse   938 YMVASGLPRRNGNRHAAEIANLALDILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPR 1002

  Fly  1069 YCLFGDTVNTASRMESNGEALKIHISETTKEA---LDEFGTFVTTRRGFVPMKGKGEMLTYWLEG 1130
            ||||||||||||||||.|...:||:|::|.:|   |||  .:....||...:||||...||||.|
Mouse  1003 YCLFGDTVNTASRMESTGLPYRIHVSQSTVQALLSLDE--GYKIDVRGQTELKGKGLEETYWLTG 1065

  Fly  1131 EV----PRPNSL-ISPSKLMLTR------------RSSLKQPQRS 1158
            :|    |.|..| |.|......|            |..|.:|::|
Mouse  1066 KVGFCRPLPTPLSIKPGDPWQDRINQEIRTGFAKARQGLAEPRKS 1110

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	91/436 (21%)
		ANF_receptor	108..473	CDD:279440	83/400 (21%)
		PK_GC-A_B	589..883	CDD:270944	102/323 (32%)
		Pkinase_Tyr	613..877	CDD:285015	95/279 (34%)
		HNOBA	<893..938	CDD:285003	21/44 (48%)
		CYCc	917..1108	CDD:214485	123/193 (64%)
		Guanylate_cyc	944..1130	CDD:278633	120/188 (64%)
Gucy2d	NP_001124165.1	PBP1_sensory_GC_DEF-like	71..445	CDD:380594	89/431 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..557		3/27 (11%)
		PK_GC-2D	554..818	CDD:270945	96/287 (33%)
		CYCc	855..1044	CDD:214485	122/190 (64%)
		Interaction with NCALD. /evidence=ECO:0000250\|UniProtKB:P51839	874..915		28/40 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1096..1117		3/14 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920