DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and Gucy2c

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_001120790.1	Gene:	Gucy2c / 14917	MGIID:	106903	Length:	1072	Species:	Mus musculus

Alignment Length:	1071	Identity:	337/1071 - (31%)
Similarity:	512/1071 - (47%)	Gaps:	214/1071 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 FEIY----TQWPEVNA-VFGLPCEY------VLAPISR----YADVWQVPVLTTGGNAKEFNKKS 200
            |::|    ..:|.::| .:||.|:|      :|.|..:    ..|.|
Mouse   129 FQMYLDTELNYPMISAGSYGLSCDYKETLTRILPPARKLMYFLVDFW------------------ 175

  Fly   201 ESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHS 265
                        :|||      |....|:| .::.:|:|.:..    ..||..|.|:...:...|
Mouse   176 ------------KVNN------ASFKPFSW-NSSYVYKNGSEP----EDCFWYLNALEAGVSYFS 217

  Fly   266 VYQLGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQI---MLTAEELNMIDSGEYVFINI 327
            .. |.|............:|.....:|.:::||..|:|...:   :..||:.        |.|.:
Mouse   218 EV-LNFKDVLRRSEQFQEILTGHNRKSNVIVMCGTPESFYDVKGDLQVAEDT--------VVILV 273

  Fly   328 ELFSRVQYL---TSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKY 389
            :|||. .|.   |:.|.|..|             ..:||:..:|...|  |.|        ||::
Mouse   274 DLFSN-HYFEENTTAPEYMDN-------------VLVLTLPSEQSTSN--TSV--------AERF 314

  Fly   390 NYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVT 454
            :...||      |..::.:|.||:.:.|...:.....     :.|....|...|.:|.|..|.||
Mouse   315 SSGRSD------FSLAYLEGTLLFGHMLQTFLENGEN-----VTGPKFARAFRNLTFQGFAGPVT 368

  Fly   455 IDANGDRLSAYSLLDMNPTTGRFEIVAHFLHNRLEFEANKEIHWAGDREEAPPDRPICGYDGALC 519
            :|.:||..:..|||.::..|.:::::..:     :...||.|             |:......:.
Mouse   369 LDDSGDIDNIMSLLYVSLDTRKYKVLMKY-----DTHKNKTI-------------PVAENPNFIW 415

  Fly   520 PDNSLP------GYAILSIVLGTM---VVVMAVCFFFGYRHYIAEAEINSMSWK-VSLEDVMFRD 574
            .::.||      |..||.|.:.|:   :||:.:......|.|..:..:....|. :..|::
Mouse   416 KNHKLPNDVPGLGPQILMIAVFTLTGILVVLLLIALLVLRKYRRDHALRQKKWSHIPSENI---- 476

  Fly   575 AAERGLRGSFHSLVKQSSQLTLMSED---MVSINGDRQIFIPVGMFRKSKVAIKPVEVDNVQGLL 636
                     |.....:::.::|..:|   ..:|...||.     .:.|.||.:|  ::.:..|..
Mouse   477 ---------FPLETNETNHISLKIDDDRRRDTIQRVRQC-----KYDKKKVILK--DLKHSDGNF 525

  Fly   637 TRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQ------LDWMF 695
            :....::|.::....:.:|.||||......|.|.:.|||.:|||:::| |:...      :||.|
Mouse   526 SEKQKIDLNKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCERGSLREVL-NDTISYPDGTFMDWEF 589

  Fly   696 RLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNS 760
            ::|:::||.:||.:||||.|..||.|||:|||||||.|:||||||                 |||
Mouse   590 KISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFG-----------------CNS 637

  Fly   761 HAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIEL 825
            .....|.|||||     ||.|....:||||||:|.||..||..|:..||...|  ....::|..:
Mouse   638 ILPPKKDLWTAP-----EHLRQATISQKGDVYSFAIIAQEIILRKETFYTLSC--RDHNEKIFRV 695

  Fly   826 VKGYNPHRMQKPFRPE--LEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRR----FNKDN 884
            ...|.     |||||:  ||...:.:.::..:::.||.|||.:||||..::|.:.:    |: |.
Mouse   696 ENSYG-----KPFRPDLFLETADEKELEVYLLVKSCWEEDPEKRPDFKKIESTLAKIFGLFH-DQ 754

  Fly   885 ETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETF 949
            :..:.:|.|::|::||:.|||.|||||||.|..|:.:.:.|.:.|||:.|...|.....|..|.:
Mouse   755 KNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFMLLPRLVVKSLKEKGIVEPELY 819

  Fly   950 DQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRN 1014
            ::||||||||||||.|...||||:||..|||:|..||.||::.||||||||||||:|.||||:||
Mouse   820 EEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHDVYKVETIGDAYVVASGLPMRN 884

  Fly  1015 GNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTA 1079
            ||:||.:|:::||.:|..:..|.:.|.|...:.:|||:|:|.|.|||||:|||||||||||||||
Mouse   885 GNRHAVDISKMALDILSFIGTFELEHLPGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTA 949

  Fly  1080 SRMESNGEALKIHISETTKEALDEFG-TFVTTRRGFVPMKGKGEMLTYWLEGEVPRPNSLISPSK 1143
            |||||.|..|:||:|.:|...|.... .|:...||...:||:|...||||.|...:..:|.||
Mouse   950 SRMESTGLPLRIHMSSSTITILKRTDCQFLYEVRGETYLKGRGTETTYWLTGMKDQEYNLPSP-- 1012

  Fly  1144 LMLTRRSSLKQPQRSQSHNLHKQYSELVVAS 1174
                       |.......|..::|:::|::
Mouse  1013 -----------PTVENQQRLQTEFSDMIVSA 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	78/367 (21%)
		ANF_receptor	108..473	CDD:279440	74/342 (22%)
		PK_GC-A_B	589..883	CDD:270944	105/308 (34%)
		Pkinase_Tyr	613..877	CDD:285015	99/271 (37%)
		HNOBA	<893..938	CDD:285003	21/44 (48%)
		CYCc	917..1108	CDD:214485	104/191 (54%)
		Guanylate_cyc	944..1130	CDD:278633	107/186 (58%)
Gucy2c	NP_001120790.1	Periplasmic_Binding_Protein_Type_1	35..415	CDD:299141	79/388 (20%)
		PKc_like	480..749	CDD:304357	104/305 (34%)
		STYKc	502..744	CDD:214568	101/278 (36%)
		CYCc	787..978	CDD:214485	104/190 (55%)
		Guanylate_cyc	814..1001	CDD:278633	107/186 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.780