DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and gucy2d

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	XP_005165318.1	Gene:	gucy2d / 140426	ZFINID:	ZDB-GENE-011128-9	Length:	1141	Species:	Danio rerio

Alignment Length:	1118	Identity:	364/1118 - (32%)
Similarity:	569/1118 - (50%)	Gaps:	130/1118 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 DCIMPKVLPVL--ELAIRHVQRMGFVG-GSHFDIQLISRDTFCSSKYGPIGFFEIYTQWPEVNAV 163
            |.:..|.||.|  .||:..:.:...:. |..:|..:|:.|  |||..|...|.|:    ....:.
Zfish    88 DPMYSKALPDLAARLAMSRINKDPELNKGYWYDYTVINED--CSSSRGLARFAEL----EGYGSA 146

  Fly   164 FGLPCE--YVLAPISRYADVWQVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILN 226
            |..|..  |..| .:..|..|...:|:.|....|.::  |.|.|..|    .:.....|:.::|.
Zfish   147 FLGPANPGYCTA-ATLLAKNWNKGILSWGCLKAEMDE--EMYPTFLR----PLPLSSRVLFSVLR 204

  Fly   227 SFNWTRTALI-YQNENAKVKGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTWTKADITRMLKNVAM 290
            .|.|....:: .:.:..:..|:.     |||        |:..||.........:..:.....|:
Zfish   205 FFRWAHVGIVTAEGDMWEATGHE-----LAA--------SLRALGLPVGKVVTMEQDKEGPRQAL 256

  Fly   291 QS-------RIVIMCADPQSI-----RQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYD 343
            |:       |:||||.....|     .|::.||.|:.|||.| |:||..:..     |.|.|:.:
Zfish   257 QAIRDTDRVRVVIMCMHSALIGGEEQYQLLTTALEMRMIDRG-YIFIPYDTL-----LYSLPYEN 315

  Fly   344 -KNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDN-EPISAFVTSF 406
             |.....|:.:.::||..:||||..|...|.|     |....|.|.:....|.: |.::.:|:.|
Zfish   316 VKYPILANDSKLRRAYDGVLTVTMDQGEQNFY-----EAFNAAQESFEIRGSTSAEEVTRWVSPF 375

  Fly   407 FDGV--LLYANAL-NESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSA-YSL 467
            |..:  ::|..|: .|..|....  .|.::|..:.:......|.|....::...||:.:.. |::
Zfish   376 FGTIYNMIYYTAMAAEQSRASSG--GRWVSGDLLSQNEGGFEFDGFNQRISGGTNGEGMQVRYAV 438

  Fly   468 LDMNPTTGRFEIVAHFL--------HNRLEFEANKEIHWAGDREEAPPDRPICGYDGALCPDNSL 524
            || :..:|......|.|        :..|:: ..|.||:||   .:|.....|.:...:.....|
Zfish   439 LD-SDGSGSSLYRTHALEASHTYGKYGGLKY-LGKSIHFAG---ASPSSDANCWFSPYIACSGGL 498

  Fly   525 PGYAILSIVLGTMVVVM-AVCFFFGYRHYIAEAEINSM--------SWKVSLEDVMFRDAAERGL 580
            .|..:..:::..:|::. |...|...|.|.|.....:.        ...::|:|::|.:......
Zfish   499 DGVTLFFLLMFFIVLIAGAGILFLQVRKYGAGGFFGAFIGGGGSPTKIVLTLDDLVFINTTLSRR 563

  Fly   581 RGSFHSLVKQSSQLTLMSEDMVSINGDRQIFIP-----VGMFRKSKVAIKPVEVDNVQGLLTRSL 640
            :.:..|::|  |||.:.: ...|::|...|...     |.:|....|.:|.....:....::.|.
Zfish   564 KLNDESMLK--SQLDVKT-PRHSVSGRSYITSTPETSNVAVFEGDWVWLKKCPCADSITEISEST 625

  Fly   641 MLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVR 705
            .....:::|::|::|..|.|..:|.....::||:|.:|||:|:|.||:.:|||||:.||:.|::|
Zfish   626 QTIFVKLRDMRHENLNLFLGLFMDTGIFGIVTEHCTRGSLEDLLNNEEMRLDWMFKSSLLLDLIR 690

  Fly   706 GMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWT 770
            ||::||:..| .||.|||.|||||.|||||:||:|.:.:...:..:..|  |.....:     ||
Zfish   691 GMKYLHNRGI-IHGRLKSRNCVVDGRFVLKVTDYGFNEILNCQNIILED--NAPEDQF-----WT 747

  Fly   771 APELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQ 835
            |||:|| ..:...:||..||||:|.||:.|:.:|..||    |..:..|:||||.|:...|
Zfish   748 APEILR-NPDLKKKGTYPGDVYSFSIIMQEVISRCAPF----CMLDMPPEEIIEKVRSPPP---- 803

  Fly   836 KPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELY 900
             ..||.:..: :...|:..::::.|:|:|.:||.|..:....:..||..:| ||:|::|:.:|.|
Zfish   804 -LCRPTVSMD-EAPLDVIQLMKQAWSEEPEQRPTFEDIFRQFKSMNKGKKT-NIIDSMLRMLEQY 865

  Fly   901 ANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAI 965
            ::|||:|:.|||::...|::|.:.||.|:||:|||..|.:|:||..|.|.:||:|||||||||.|
Zfish   866 SSNLEDLIRERTEELEVERQKTDALLAQMLPKSVALALKTGKPVKPEHFAEVTLYFSDIVGFTTI 930

  Fly   966 SAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALL 1030
            ||.|.|::||..||||||.||.|:...||||||||||||||.||:|.|||.:||.|:|.::|.:|
Zfish   931 SALSEPIEVVDLLNDLYTHFDGIIAIHDVYKVETIGDAYMVASGVPNRNGTRHAAEMANMSLDIL 995

  Fly  1031 EAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISE 1095
            ..:..|::.|.|:.::|:|||||:|..|||||||||||||||||||||||||||.|...:||:::
Zfish   996 HCIGTFKMRHMPDVKVKIRIGLHSGPVVAGVVGLKMPRYCLFGDTVNTASRMESTGLPYRIHVNQ 1060

  Fly  1096 TTKEALD--EFGTFVTTRRGFVPMKGKGEMLTYWLEGE------VPRPNSL--------ISPSKL 1144
            :|.:.|:  :.|..:.| ||...:||||...|:||.|.      :|.|..|        ||..::
Zfish  1061 STVDVLNSLKLGYKIDT-RGRTELKGKGVEETFWLVGRDGFDKPLPIPPDLTPGASNHGISLDEI 1124

  Fly  1145 MLTRRSSLKQPQR 1157
            ...||......|:
Zfish  1125 PTDRRQKFLDRQK 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	101/427 (24%)
		ANF_receptor	108..473	CDD:279440	93/388 (24%)
		PK_GC-A_B	589..883	CDD:270944	100/298 (34%)
		Pkinase_Tyr	613..877	CDD:285015	92/268 (34%)
		HNOBA	<893..938	CDD:285003	20/44 (45%)
		CYCc	917..1108	CDD:214485	112/192 (58%)
		Guanylate_cyc	944..1130	CDD:278633	109/187 (58%)
gucy2d	XP_005165318.1	PBP1_sensory_GC_DEF_like	78..470	CDD:107366	99/422 (23%)
		PK_GC-2D	581..849	CDD:270945	96/286 (34%)
		HNOBA	<858..903	CDD:311573	20/44 (45%)
		CYCc	883..1075	CDD:214485	112/191 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920