DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and gc2

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	XP_021333059.1	Gene:	gc2 / 140425	ZFINID:	ZDB-GENE-011128-8	Length:	1120	Species:	Danio rerio

Alignment Length:	1222	Identity:	384/1222 - (31%)
Similarity:	573/1222 - (46%)	Gaps:	243/1222 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 HSFKTPETKNSHKSQSTELVQHFPSLPMPDHRRLGARRQLVFVALLPSVESDN---------KND 102
            |||......:..:|.|.  :.||.|  .|.|..|......:.:.|||:..:..         ..|
Zfish     9 HSFLPARGTSGLRSPSQ--MPHFSS--DPKHIYLCLLWSTIILCLLPATNAATIKVGVVGPWSCD 69

  Fly   103 CIMPKVLP--VLELAIRHVQRMGFVG-GSHFDIQLISRD--------------TFCSSKYGPI-- 148
            .|..|..|  ...||:.|:.:..::. |..||..::..|              |..|...||:
Zfish    70 PIFTKAQPGVAARLAVAHINKDPYLSQGITFDYIILDEDCETSKSFARFLGYYTRASGFIGPVNP 134

  Fly   149 GFFE----IYTQWPEVNAVFGLPC-EYVLAPI---SRYADVWQVPVLTTGGNAKEFNKKSESYST 205
            |:.|    :...|.:  |||...| |:.|..:   ..:|....||.|
Zfish   135 GYCEAASLLGKSWNK--AVFSWSCIEHELDDVRSHPTFARTMPVPSL------------------ 179

  Fly   206 LTRLKGAQVNNLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLCLAAIH--DTIEEHSVYQ 268
                          |:.:.:..|.|....:|..:|:..|:         |||.  :.:..|.: .
Zfish   180 --------------VLLSFMRHFRWAHVGIISSSEDVWVE---------AAIKLANALRSHGL-P 220

  Fly   269 LGFDTSTWTKADITRMLKNVA-----MQSRIVIMCADPQSI-----RQIMLTAEELNMIDSGEYV 323
            :|..||  .:.|.|.:.:.:|     ...|:||:......|     :.::.||.::.|.| |..|
Zfish   221 VGIVTS--ARNDHTSVRQTLAKVRKVADLRLVILVMHSVLIGGRTQKLLLETAHDMRMTD-GSLV 282

  Fly   324 FINIE-LFSRVQYLTSQPWYDKNDTDLN-NERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAA 386
            |::.: ||      .|.|::......|. |.:..:||.|:||:|.:.|.:..:.:        |.
Zfish   283 FMSYDTLF------YSLPYHHVTQPALRYNSKLLRAYDAVLTITIESPKEQSFYQ--------AF 333

  Fly   387 EKYNYTFSDNE--------PISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWN 443
            ||..   .|.|        .:|....:.:..::..|:|: :|:|.....:    :|.::.:...|
Zfish   334 EKAQ---EDGELPKHLKPQQVSPLFGTIYSSIVFMAHAV-QSVRAAGQWM----SGGNIAQNARN 390

  Fly   444 RSFTGITGNVTIDANGDRLSA--YSLLD-------MNPTTGRFEI---VAHFLHNRLEFEANKEI 496
            ..|   .|..::.||......  |.:||       :.||. |.|:   :..||...:.|.
Zfish   391 LLF---KGGSSLQANSSDFGMLDYVILDTDGFSWELQPTY-RIEMQTDMVRFLGRHIHFP----- 446

  Fly   497 HWAGDREEAPP--DRPICGYDGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAE-- 557
             :||     ||  |.......|.:|.......:.|...:||.:.:.:::...:..|..|.:..
Zfish   447 -YAG-----PPRTDSSCWFTHGIICRGGVNLFHMISMFLLGFLFIFLSIGCSYCIRRKINKIRLV 505

  Fly   558 ---------INSMSW--------KVSLEDVMFRDAAERGLRGSFHSLVKQSSQLTLMSEDMVSIN 605
                     :|.:::        |:|::|....|........|..|.:...|..|..:.::....
Zfish   506 RGPNKILLTLNDVTFINPSLSNKKLSVDDSKASDTRMSISERSLVSPMSSQSPATYENSNVAIYE 570

  Fly   606 GDRQIF--IPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRS 668
            ||....  :|.|.||    :|.|...|          :.||  ||||:|:::..|.|...|....
Zfish   571 GDWAWMKRLPYGTFR----SITPNTSD----------VFEL--MKDLRHENINPFLGFFHDCGVF 619

  Fly   669 FLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFV 733
            .::||:|.:|||:|:|.|:..:|||||:.||:.|:::||::||..:: .||.|||.|||||.|||
Zfish   620 AIVTEFCSRGSLEDLLVNDDVKLDWMFKSSLILDLIKGMKYLHHRNV-CHGRLKSRNCVVDGRFV 683

  Fly   734 LKITDFGLH-TLRRTRFD-LESDGGNCNSHAYWSKLLWTAPELLRVEHNRPP--EGTQKGDVYAF 794
            |||||:|.: .|...||. :|...         ..|||||||:||..:   |  .||..||||:|
Zfish   684 LKITDYGYNEVLESQRFPYIEPPA---------EDLLWTAPEILRGSY---PGLHGTHSGDVYSF 736

  Fly   795 GIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPF-RPELEPNGDTKADINGIIRR 858
            .||:.|:..|..||    |..|.:..||::.|:  .|..|.:|. .|:..|     .:...::::
Zfish   737 SIIMQEVVMRGPPF----CMLENTFDEIVQKVR--KPPPMCRPIVSPDHAP-----MECIQLMKQ 790

  Fly   859 CWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCE 923
            ||.|.|.:||.|:.:....:..||..:| ||:|::|:.:|.|::|||||:.|||::...||:|.|
Zfish   791 CWNEQPEKRPTFDEIFDQFKNVNKGKKT-NIIDSMLRMLEQYSSNLEELIRERTEELEIEKQKTE 854

  Fly   924 KLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSI 988
            |||.|:||.|||..|..|..|..|.|:.|::|||||||||.|||.|.|::||..||||||.||::
Zfish   855 KLLTQMLPPSVAEALKLGTTVEPEHFESVSLYFSDIVGFTTISANSEPIEVVDLLNDLYTTFDAV 919

  Fly   989 VENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLH 1053
            :.|.||||||||||||||.||:|:.|||:||.|||.:||.:|.||..||:.|.|:..:::|||||
Zfish   920 IGNHDVYKVETIGDAYMVASGVPVPNGNRHAAEIANMALDILSAVGTFRMRHMPDVPVRIRIGLH 984

  Fly  1054 TGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGT-FVTTRRGFVPM 1117
            ||.||||||||.|||||||||||.|||||||.|...:||:..:|.:.|.|... :....|....:
Zfish   985 TGPCVAGVVGLTMPRYCLFGDTVTTASRMESTGLPYRIHVHSSTVKILMELKLGYRVELRARTEL 1049

  Fly  1118 KGKGEMLTYWLEGE------VPRPNSLIS-----PSKLMLTRR----SSLKQ 1154
            |||....||||.|.      :|.|..|.|     ..|:||.:.    |:::|
Zfish  1050 KGKRIEETYWLTGRDGFTKPLPVPPVLKSGLESKDFKVMLKKAVRKISTVRQ 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	97/479 (20%)
		ANF_receptor	108..473	CDD:279440	84/422 (20%)
		PK_GC-A_B	589..883	CDD:270944	106/300 (35%)
		Pkinase_Tyr	613..877	CDD:285015	101/268 (38%)
		HNOBA	<893..938	CDD:285003	24/44 (55%)
		CYCc	917..1108	CDD:214485	117/191 (61%)
		Guanylate_cyc	944..1130	CDD:278633	110/186 (59%)
gc2	XP_021333059.1	PBP1_sensory_GC_DEF_like	59..440	CDD:107366	92/453 (20%)
		PK_GC-2D	551..815	CDD:270945	107/303 (35%)
		HNOBA	<824..869	CDD:311573	24/44 (55%)
		CYCc	848..1040	CDD:214485	117/191 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820