DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and gucy2f

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_571939.2	Gene:	gucy2f / 140424	ZFINID:	ZDB-GENE-011128-7	Length:	1107	Species:	Danio rerio

Alignment Length:	997	Identity:	341/997 - (34%)
Similarity:	514/997 - (51%)	Gaps:	149/997 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 ESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTALIYQNEN------AKV------KGNSVCFLC 253
            :.|.|..|...:.:..|.||    |..|.|....::..||:      ||:      :|..|..:.
Zfish   165 QGYPTFARTLPSPLRVLFNV----LKFFRWANIGIVSSNEDIWIDTAAKLASALRNRGLPVGIVT 225

  Fly   254 LAAIHDTIEEHSVYQLGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSI---RQIMLTAEELN 315
            ....:||:.|:::..                :|| |...:::|||.....|   :|.....:..:
Zfish   226 SMGNNDTMLENTLMS----------------IKN-AGDIKVIIMCMHSVLIGGEQQATFLTKAYD 273

  Fly   316 M-IDSGEYVFINIELFSRVQYLTSQPWYDKNDTDL-NNERAQKAYTAMLTVTPKQPNDNEYTRVS 378
            | :.||.||||..:..     |.|.|:.:.....| ||.:..|||.|:||:|           :.
Zfish   274 MGLASGRYVFIPYDTL-----LYSLPYINITYYPLQNNSKLSKAYDAVLTIT-----------LD 322

  Fly   379 NEIKAI-----AAEKYNYTFSDNEP--ISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTD 436
            ::|...     ||::........||  :|....:.::.:.|.|.:::.:.|..     |.::||:
Zfish   323 SDIMTFNEAFNAAKQLGELMVTQEPEQVSPLFGTIYNSLYLLAKSMHNARRAG-----RWLSGTN 382

  Fly   437 MVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNP-TTGRFEIVAHFLHNRLEFEANKEIHWAG 500
            :.....|.:|||...::..|..|:..:.|.:||... .|..:......:.:.|...|.:.||:.|
Zfish   383 LAYFTRNITFTGFNQDIQTDEQGNGQTNYVILDTEAWGTQLYRCFLVDMTSDLVLFAGRFIHFPG 447

  Fly   501 DREEAPPDRPICGY-DGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWK 564
              |..||....|.: |.|:|.......|.|::.|:..::|:.::......|..|.:.::.....:
Zfish   448 --ESPPPSDSRCWFEDNAICTGGVDIIYVIIAFVIVLIIVLGSIGLSLFIRRRIQQIQLIKGPNR 510

  Fly   565 V--SLEDVMFRDAAERGLRGSFHSLVKQSSQLTLMSEDMVSI----NGDRQIFIPVGMFRKSKVA 623
            :  :|||:.|.:.          .|.|:...|..:|:....|    .|||...:       :.:|
Zfish   511 ILLTLEDLTFINP----------QLSKRKITLEDLSDSKSYIEEKSTGDRSRSV-------NSMA 558

  Fly   624 IKPVEVDNV---QG------LLTRSLMLELK--------RMKDLQHDHLVKFYGACLDQRRSFLL 671
            ....|..||   :|      ..|.....|:|        :||||:::::..|.|...|.....::
Zfish   559 TATHETSNVAVYEGDWVWLKKFTEGHFKEVKQSTTKIFTKMKDLRNENVNPFLGFFTDCEMFAIV 623

  Fly   672 TEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKI 736
            ||:|.:|||.|:|.|:..:|||||:.||:.|:::||::||..:. .||.|||.|||||.||||||
Zfish   624 TEHCSRGSLHDLLRNDDVKLDWMFKSSLVLDLIKGMKYLHHREF-PHGRLKSRNCVVDGRFVLKI 687

  Fly   737 TDFG----LHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGII 797
            ||:|    |.|.:..:..|..:           .|.|||||.|| :...|.:||.|||||:|.||
Zfish   688 TDYGYNEILETQKAPKETLPPE-----------DLFWTAPEHLR-DPESPRKGTYKGDVYSFAII 740

  Fly   798 VHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKP---FRPELEPNGDTKADINGIIRRC 859
            :.|:..|..|:    |....||:|||..||        ||   .||.:.|: ....:...::::|
Zfish   741 LQEVVVRGAPY----CMLGLSPEEIIRKVK--------KPPPMCRPTVAPD-QAPLECIQLMKQC 792

  Fly   860 WAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEK 924
            |:|.|..||.|:.:....:..||..:| ||:|::|:.:|.|::|||:|:.|||::...||::.||
Zfish   793 WSEQPDRRPPFDQIFDQFKLINKGKKT-NIIDSMLRMLEQYSSNLEDLIRERTEELEVEKQRTEK 856

  Fly   925 LLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIV 989
            ||.::||.|||..|.:|..|..|.|||||||||||||||.||:.|.|::||..|||||:.||:::
Zfish   857 LLSEMLPPSVAEALKTGASVEPEYFDQVTIYFSDIVGFTTISSLSDPIEVVDLLNDLYSLFDAVL 921

  Fly   990 ENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHT 1054
            .:.||||||||||||||.||||.:|||:||.|||.::|.:|.:|.:|::.|.||..:::|||:|:
Zfish   922 GSHDVYKVETIGDAYMVASGLPKKNGNKHAAEIANMSLNILSSVGSFKMRHMPEVPVRIRIGIHS 986

  Fly  1055 GACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGT-FVTTRRGFVPMK 1118
            |.||||||||.|||||||||||||||||||.|...:||::.:|.:.|..... :....||...:|
Zfish   987 GPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNISTVQILRSLNDGYKIDVRGKTELK 1051

  Fly  1119 GKGEMLTYWLEGEV----PRPN 1136
            |||...||||.|:.    |.||
Zfish  1052 GKGIEETYWLVGKANFTKPLPN 1073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	71/321 (22%)
		ANF_receptor	108..473	CDD:279440	67/296 (23%)
		PK_GC-A_B	589..883	CDD:270944	108/321 (34%)
		Pkinase_Tyr	613..877	CDD:285015	100/287 (35%)
		HNOBA	<893..938	CDD:285003	21/44 (48%)
		CYCc	917..1108	CDD:214485	113/191 (59%)
		Guanylate_cyc	944..1130	CDD:278633	110/186 (59%)
gucy2f	NP_571939.2	PBP1_sensory_GC_DEF_like	59..440	CDD:107366	69/316 (22%)
		PK_GC-2D	551..816	CDD:270945	101/297 (34%)
		HNOBA	<825..870	CDD:311573	21/44 (48%)
		CYCc	850..1042	CDD:214485	113/191 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820