DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and Adcy9

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	XP_011244107.1	Gene:	Adcy9 / 11515	MGIID:	108450	Length:	1372	Species:	Mus musculus

Alignment Length:	437	Identity:	106/437 - (24%)
Similarity:	183/437 - (41%)	Gaps:	96/437 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   889 IVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVT 953
            |.|:|:|:.:..:.|  .:....|......|||          .|:....|:.:|...:..::|:
Mouse   342 IADDLMKQGDEESEN--SVKRHATSSPKNRKKK----------SSIQKAPIAFRPFKMQQIEEVS 394

  Fly   954 IYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQH 1018
            |.|:||||||.:||..:...:|..||||:..||.:.|.....|:.|:||.|..|:|.|....: |
Mouse   395 ILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEQTKCEKISTLGDCYYCVAGCPEPRAD-H 458

  Fly  1019 AREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRME 1083
            |.....:.|.:::|:..|  ....::.:.:|:|:|||..:.|::|::..::.::.:.||.|:.||
Mouse   459 AYCCIEMGLGMIKAIEQF--CQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLME 521

  Fly  1084 SNGEALKIHISETTKEALDE------------FGTFVTTRRGFVPMKGKGEMLTYWLEGEVPRPN 1136
            ..|.|.|:||||.|.:.||:            .|..|...:    :||   :.||.:.|:..: .
Mouse   522 QLGVAGKVHISEATAKYLDDRYEMEDGRVIERLGQSVVADQ----LKG---LKTYLISGQRAK-E 578

  Fly  1137 SLISPSKLML--------TRRSSLKQPQRSQSHNLHKQYSELVVASPPPQLPPPAIALPPPPSPS 1193
            |..|.::.:|        :|.||..:.|.:.|.......::.|......:..|.......|.|.:
Mouse   579 SHCSCAEALLSGFEVIDDSRESSGPRGQGTASPGSVSDLAQTVKTFDNLKTCPSCGITFAPKSEA 643

  Fly  1194 -----------KDSPNLRVKRKISSS------------SPKLNGGGFDYHKTENHYLDTAAAAQR 1235
                       :|.|  :...|::||            .||.:||  ...||:|..|...|..:.
Mouse   644 GAEGGTVQNGCQDEP--KTSTKVTSSWLLFLSVPLLAHPPKASGG--PNSKTQNGLLSPPAEEKL 704

  Fly  1236 N------CDIYSSRS----------------LRDMEETSDSWELAHF 1260
            .      |:|...:.                .:::.|.:|    |||
Mouse   705 TNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTD----AHF 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944
		Pkinase_Tyr	613..877	CDD:285015
		HNOBA	<893..938	CDD:285003	8/44 (18%)
		CYCc	917..1108	CDD:214485	61/202 (30%)
		Guanylate_cyc	944..1130	CDD:278633	60/197 (30%)
Adcy9	XP_011244107.1	MFS	<134..260	CDD:391944
		Guanylate_cyc	385..573	CDD:306677	60/197 (30%)
		Guanylate_cyc	1069..1260	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900