DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and ADCY9

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	XP_005255136.1	Gene:	ADCY9 / 115	HGNCID:	240	Length:	1372	Species:	Homo sapiens

Alignment Length:	683	Identity:	149/683 - (21%)
Similarity:	261/683 - (38%)	Gaps:	197/683 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   718 HGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRP 782
            |..|..|.|:..:..||..| ||.|......|.....|.          |.|   |||
Human   239 HLPLYLSLCLGVAYSVLFET-FGYHFRDEACFPSPGAGA----------LHW---ELL------- 282

  Fly   783 PEGTQKGDVYAFGI---IVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEP 844
            ..|...|.::|.|:   ::.::.:|.....:|:........|:.:.:|    .||
Human   283 SRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALK----ERM---------- 333

  Fly   845 NGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVE 909
                   |:.::.|..|:|            ::::.::::|      |.:||
Human   334 -------IHSVMPRIIADD------------LMKQGDEESE------NSVKR------------- 360

  Fly   910 ERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQV 974
            ..|......|||          .|:....|:.:|...:..::|:|.|:||||||.:||..:...:
Human   361 HATSSPKNRKKK----------SSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHAL 415

  Fly   975 VQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIH 1039
            |..||||:..||.:.|.....|:.|:||.|..|:|.|....: ||.....:.|.:::|:..|  .
Human   416 VGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRAD-HAYCCIEMGLGMIKAIEQF--C 477

  Fly  1040 HRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDE- 1103
            ...::.:.:|:|:|||..:.|::|::..::.::.:.||.|:.||..|.|.|:||||.|.:.||:
Human   478 QEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDR 542

  Fly  1104 -----------FGTFVTTRRGFVPMKGKGEMLTYWLEGEVPRPNSLISPSKLMLT-----RRSSL 1152
                       .|..|...:    :||   :.||.:.|:..: .|..|.::.:|:     ..|.:
Human   543 YEMEDGKVIERLGQSVVADQ----LKG---LKTYLISGQRAK-ESRCSCAEALLSGFEVIDGSQV 599

  Fly  1153 KQPQRSQ----SHNLH------KQYSELVVASPPPQLPPPAIALPP----------PPSPSKDSP 1197
            ....|.|    |.|:.      |.:..|...      |...|...|          |.:..:|..
Human   600 SSGPRGQGTASSGNVSDLAQTVKTFDNLKTC------PSCGITFAPKSEAGAEGGAPQNGCQDEH 658

  Fly  1198 NLRVKRKISSS------------SPKLNGGGFDYHKTENHYL-----DTAAAAQRN-CDIYSSRS 1244
              :...|::||            .||.:||  ...||:|..|     :....:|.: |:|...:.
Human   659 --KNSTKVTSSWLLFLSVPLLAHPPKASGG--PNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKG 719

  Fly  1245 ----------------LRDMEETSDSWELAHF--RLPLSGALKSHHH---LNNNSHGYV-----H 1283
                            .:::.|.:|    |||  .:.....:|.:..   :|..|..::     .
Human   720 RWAGVSLDQSALLPLRFKNIREKTD----AHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELER 780

  Fly  1284 SNSSSNLSGILQPPPLGVQRTRLKPSPTISTLL 1316
            |..:|....:::..|:     :...|||.|:||
Human   781 SYRTSYQEEVIKNSPV-----KTFASPTFSSLL 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944	31/167 (19%)
		Pkinase_Tyr	613..877	CDD:285015	31/161 (19%)
		HNOBA	<893..938	CDD:285003	7/44 (16%)
		CYCc	917..1108	CDD:214485	61/202 (30%)
		Guanylate_cyc	944..1130	CDD:278633	60/197 (30%)
ADCY9	XP_005255136.1	DUF2339	<118..>301	CDD:287113	21/82 (26%)
		CYCc	326..544	CDD:214485	72/282 (26%)
		Guanylate_cyc	385..573	CDD:278633	60/197 (30%)
		CYCc	1043..1243	CDD:214485
		Guanylate_cyc	1069..1260	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810