DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG31183 and Gucy2e

DIOPT Version :9

Sequence 1:NP_001287342.1 Gene:CG31183 / 41927 FlyBaseID:FBgn0051183 Length:1417 Species:Drosophila melanogaster
Sequence 2:NP_570093.2 Gene:Gucy2e / 113911 RGDID:69322 Length:1123 Species:Rattus norvegicus


Alignment Length:1135 Identity:361/1135 - (31%)
Similarity:545/1135 - (48%) Gaps:175/1135 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   102 DC--IMPKVLPVL--ELAIRHV-QRMGFVGGSHFDIQLISRDTFCSSKYGPIGFFEIYTQWPEVN 161
            ||  |..:.||.:  :||:..| |....:.||..|.:::  .|.|.:.:.    ...:.......
  Rat    79 DCDPIFAQALPSMATQLAVDRVNQDASLLLGSQLDFKIL--PTGCDTPHA----LATFVAHRNTV 137

  Fly   162 AVFGLPCEYVLAPISR-YADVWQVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNNL---GNVVR 222
            |.|..|......|.:. .|..|...:.:....|.|..             ||.|..|   .:|:.
  Rat   138 AAFIGPVNPGYCPAAALLAQGWGKSLFSWACGAPEGG-------------GALVPTLPSMADVLL 189

  Fly   223 AILNSFNWTRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTWT----KADITR 283
            :::..|.|.|.|::..:::       :.......:......|.: .:|..||...    ..::.:
  Rat   190 SVMRHFGWARLAIVSSHQD-------IWVTTAQQLATAFRAHGL-PIGLITSLGPGEKGATEVCK 246

  Fly   284 MLKNVAMQSRIVIMCADPQSI----RQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDK 344
            .|.:| ...:||::|.....:    :.::|.......:..|..||:..:..     |.:.|:.::
  Rat   247 QLHSV-HGLKIVVLCMHSALLGGLEQTVLLRCARKEGLTDGRLVFLPYDTL-----LFALPYRNR 305

  Fly   345 NDTDLNNE-RAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDN---EPISAFVTS 405
            :...|::: ..|:||.|:||::         ...|.|..|..|.|.....:.|   |.:|....:
  Rat   306 SYLVLDDDGPLQEAYDAVLTIS---------LDTSPESHAFTATKMRGGTAANLGPEQVSPLFGT 361

  Fly   406 FFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDM 470
            .:|.|:|.|:|||.|....     ..::|..:...:......|.:..:.||..|.||..|.:||.
  Rat   362 IYDAVILLAHALNHSEAHG-----TGLSGAHLGNHIRALDVAGFSQRIRIDGKGRRLPQYVILDT 421

  Fly   471 NPTTGRFEIVAHFL--HNRLEFEANKEIHWAGDREEAPPDRPI-CGYD-GALCPDNSLPGYAILS 531
            | ..|...:..|.|  ..:........:|:.|.   :||.|.. |.:| ..||    :.|...|.
  Rat   422 N-GEGSQLVPTHILDVSTQQVQPLGTAVHFPGG---SPPARDASCWFDPNTLC----IRGVQPLG 478

  Fly   532 IVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQSSQLTL 596
            .:| |:.:...:....|:..|.....:..:                |.|||. |.::....:||.
  Rat   479 SLL-TLTITCVLALVGGFLAYFIRLGLQQL----------------RLLRGP-HRILLTPQELTF 525

  Fly   597 M--------------SEDMVSING----------DRQI--FIP---VGMFRKSKVAIKPVEVDNV 632
            :              ||....::|          .|.:  |:.   |.:::...|.:|..|....
  Rat   526 LQRTPSRRRPHVDSGSESRSVVDGGSPQSVIQGSTRSVPAFLEHTNVALYQGEWVWLKKFEAGTA 590

  Fly   633 QGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRL 697
            ..|...||.| |::|::::|:::..|.|..:....|.::.|:|.:|||:|:|.||..:|||.|:.
  Rat   591 PDLRPSSLSL-LRKMREMRHENVTAFLGLFVGPEVSAMVLEHCARGSLEDLLRNEDLRLDWTFKA 654

  Fly   698 SLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHA 762
            ||:.|::||:::||.... .||.|||.|||||:||||||||.|....      |||   :|:...
  Rat   655 SLLLDLIRGLRYLHHRHF-PHGRLKSRNCVVDTRFVLKITDHGYAEF------LES---HCSFRP 709

  Fly   763 YWS--KLLWTAPELLRVEHN--RPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEII 823
            ..:  :||||||||||....  .|.:.|.||||::.|||:.|:.||..|:    |::..|.:|||
  Rat   710 QPAPEELLWTAPELLRGPRRPWGPGKATFKGDVFSLGIILQEVLTRDPPY----CSWGLSAEEII 770

  Fly   824 ELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGN 888
            ..|....|     ..||.:.|:......|. :::.||.|.|.:||..:.:.:..:..|:..:| :
  Rat   771 RKVASPPP-----LCRPLVSPDQGPLECIQ-LMQLCWEEAPDDRPSLDQIYTQFKSINQGKKT-S 828

  Fly   889 IVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVT 953
            :.|::|:.:|.|:.:||.||:|||::...|::|.|:||.|:||.|||..|..|..|..|.|||||
  Rat   829 VADSMLRMLEKYSQSLEGLVQERTEELELERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVT 893

  Fly   954 IYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQH 1018
            ||||||||||.|||.|.|::||.|||||||.||:::::.||||||||||||||.||||.||||:|
  Rat   894 IYFSDIVGFTTISALSEPIEVVGFLNDLYTMFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRH 958

  Fly  1019 AREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRME 1083
            |.|||.:||.:|....|||:.|.|:..:::|.|||:|.||||||||.||||||||||||||||||
  Rat   959 AAEIANMALEILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRME 1023

  Fly  1084 SNGEALKIHISETTKEA---LDEFGTFVTTRRGFVPMKGKGEMLTYWLEGEVPRPNSLISPSKL- 1144
            |.|...:||:|..|.:|   |||  .:....||...:||||...||||.|:.....||.:|..: 
  Rat  1024 STGLPYRIHVSRNTVQALLSLDE--GYKIDVRGQTELKGKGLEETYWLTGKTGFCRSLPTPLSIQ 1086

  Fly  1145 ----------------MLTRRSSLKQPQRS 1158
                            ....|.||.:|:.|
  Rat  1087 PGDPWQDHINQEIRTGFAKARQSLAEPRSS 1116

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31183NP_001287342.1 PBP1_NPR_like 88..498 CDD:107368 83/418 (20%)
ANF_receptor 108..473 CDD:279440 77/383 (20%)
PK_GC-A_B 589..883 CDD:270944 105/326 (32%)
Pkinase_Tyr 613..877 CDD:285015 97/270 (36%)
HNOBA <893..938 CDD:285003 21/44 (48%)
CYCc 917..1108 CDD:214485 122/193 (63%)
Guanylate_cyc 944..1130 CDD:278633 119/188 (63%)
Gucy2eNP_570093.2 PBP1_sensory_GC_DEF-like 71..445 CDD:380594 83/413 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 529..556 3/26 (12%)
PK_GC-2D 554..824 CDD:270945 100/290 (34%)
CYCc 861..1050 CDD:214485 121/190 (64%)
Interaction with NCALD. /evidence=ECO:0000269|PubMed:18178149 880..921 28/40 (70%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D123766at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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