DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and ADCY6

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_001377760.1	Gene:	ADCY6 / 112	HGNCID:	237	Length:	1168	Species:	Homo sapiens

Alignment Length:	248	Identity:	80/248 - (32%)
Similarity:	133/248 - (53%)	Gaps:	25/248 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   898 ELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQ----VTIYFSD 958
            :|.|...:|.:|| .|.|:      .:||:.:||:.|||..::.:....|.:.|    |.:.|:.
Human   927 KLQATGEKEEMEE-LQAYN------RRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFAS 984

  Fly   959 IVGFT----AISAESTPMQVVQFLNDLYTCFDSIV--ENF-DVYKVETIGDAYMVVSGLPIRN-- 1014
            |..|:    .:.|.:..::.::.||::...||.|:  |.| .:.|::|||..||..|||....
Human   985 IANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYD 1049

  Fly  1015 --GNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVN 1077
              |..|...:|..|:.|:|.:.:  |:....:..:::|||:.|..||||:|.:.|:|.::|:|||
Human  1050 QVGRSHITALADYAMRLMEQMKH--INEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVN 1112

  Fly  1078 TASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEG 1130
            .:|||:|.|...:|.::....:.|...| :....||.|.:||||||.||:|.|
Human  1113 VSSRMDSTGVPDRIQVTTDLYQVLAAKG-YQLECRGVVKVKGKGEMTTYFLNG 1164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944
		Pkinase_Tyr	613..877	CDD:285015
		HNOBA	<893..938	CDD:285003	14/39 (36%)
		CYCc	917..1108	CDD:214485	60/205 (29%)
		Guanylate_cyc	944..1130	CDD:278633	65/200 (33%)
ADCY6	NP_001377760.1	AC_N	<16..368	CDD:318454
		Guanylate_cyc	370..554	CDD:306677
		DUF1053	582..668	CDD:399378
		Guanylate_cyc	970..1164	CDD:306677	64/196 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810