DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and ADCY2

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_065433.2	Gene:	ADCY2 / 108	HGNCID:	233	Length:	1091	Species:	Homo sapiens

Alignment Length:	372	Identity:	99/372 - (26%)
Similarity:	167/372 - (44%)	Gaps:	71/372 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   807 PFYLGRCA-------------YEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRR 858
            |:::..|.             ||.....::..:.|||...:.            |.|.:.|...:
Human   738 PYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLH------------THAHVLGDYSQ 790

  Fly   859 CWAEDPAERPDFNTLKSM-IRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKC 922
            ...|.|....|..|:.|: :..|       .|...:|.|...|...|:.|.:.:.:...||.:..
Human   791 VLFERPGIWKDLKTMGSVSLSIF-------FITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETM 848

  Fly   923 EK----LLYQLLPQSVA----AQLISGQPVVAETFDQVTIYFSDIVGFTAISAES----TPMQVV 975
            |.    ||..:||..||    |:.:..:.:..:::|.|.:.|:.|..|.....||    ..::.:
Human   849 ENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECL 913

  Fly   976 QFLNDLYTCFDSIVEN---FDVYKVETIGDAYMVVSGLPIRNGNQHARE----------IARLAL 1027
            :.||::...||.::..   ..|.|::|||..||..:||......:|::|          :...|.
Human   914 RLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAF 978

  Fly  1028 AL---LEAV--HNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGE 1087
            ||   |:|:  |:|       :..|||:|::.|..:|||:|.:.|:|.::|:|||.||||:|.|.
Human   979 ALVGKLDAINKHSF-------NDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGV 1036

  Fly  1088 ALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGEVPR 1134
            ..||.::|.|...|...| :..|.||.:.:||||::.||::..|:.|
Human  1037 LDKIQVTEETSLVLQTLG-YTCTCRGIINVKGKGDLKTYFVNTEMSR 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944	16/89 (18%)
		Pkinase_Tyr	613..877	CDD:285015	15/83 (18%)
		HNOBA	<893..938	CDD:285003	15/52 (29%)
		CYCc	917..1108	CDD:214485	66/220 (30%)
		Guanylate_cyc	944..1130	CDD:278633	65/207 (31%)
ADCY2	NP_065433.2	AC_N	<33..260	CDD:292831
		CYCc	236..439	CDD:214485
		Guanylate_cyc	281..465	CDD:278633
		DUF1053	495..599	CDD:283888
		CYCc	848..1056	CDD:214485	64/215 (30%)
		Guanylate_cyc	878..1077	CDD:278633	65/206 (32%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	905..922		2/16 (13%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	990..993		2/9 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810