DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and ADCY1

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_066939.1	Gene:	ADCY1 / 107	HGNCID:	232	Length:	1119	Species:	Homo sapiens

Alignment Length:	337	Identity:	102/337 - (30%)
Similarity:	163/337 - (48%)	Gaps:	57/337 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   890 VDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQP----VVAETFD 950
            ||..|:...|:|...|   ||| :|..:.|....::|:.|||..||...:...|    :..:::.
Human   805 VDIRLRLDYLWAAQAE---EER-EDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYS 865

  Fly   951 QVTIYFSDIVGFT----AISAESTPMQVVQFLNDLYTCFDSIVE-NF--DVYKVETIGDAYMVVS 1008
            ||.:.|:.|..|.    .:...:..::.::.||::...||.::| :|  |:.|::|||..||...
Human   866 QVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAV 930

  Fly  1009 GLPIRNG-------NQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKM 1066
            ||...:|       :.|...:|..|:.:.:.:.  .|:::..:...||:|::.|..||||:|.:.
Human   931 GLAPTSGTKAKKSISSHLSTLADFAIEMFDVLD--EINYQSYNDFVLRVGINVGPVVAGVIGARR 993

  Fly  1067 PRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFG-TFVTTRRGFVPMKGKGEMLTYWLEG 1130
            |:|.::|:|||.||||:|.|...:|.::|.....|.... .||.  ||.|.:|||||||||:|||
Human   994 PQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVC--RGKVSVKGKGEMLTYFLEG 1056

  Fly  1131 EVPRPNSLISPSKLMLTR------RSSLKQPQRSQSHNLHKQYSELVVASPPPQLPPPAIALP-- 1187
            ......|.|  ..|.|.|      |:.| |.:|                  ||..|.|.:::.
Human  1057 RTDGNGSQI--RSLGLDRKMCPFGRAGL-QGRR------------------PPVCPMPGVSVRAG 1100

  Fly  1188 -PPPSPSKDSPN 1198
             ||.||.:..|:
Human  1101 LPPHSPGQYLPS 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944
		Pkinase_Tyr	613..877	CDD:285015
		HNOBA	<893..938	CDD:285003	15/44 (34%)
		CYCc	917..1108	CDD:214485	57/209 (27%)
		Guanylate_cyc	944..1130	CDD:278633	64/200 (32%)
ADCY1	NP_066939.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		AC_N	<161..292	CDD:292831
		CYCc	258..453	CDD:214485
		Guanylate_cyc	294..476	CDD:278633
		Interaction with calmodulin. /evidence=ECO:0000250	493..520
		CYCc	826..1037	CDD:214485	58/212 (27%)
		Guanylate_cyc	859..1056	CDD:278633	64/200 (32%)
		Interaction with calmodulin. /evidence=ECO:0000250	1024..1047		8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810