DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and npr3

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	XP_004910476.1	Gene:	npr3 / 100495974	XenbaseID:	XB-GENE-1012470	Length:	508	Species:	Xenopus tropicalis

Alignment Length:	475	Identity:	144/475 - (30%)
Similarity:	236/475 - (49%)	Gaps:	50/475 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 VALLPSVESDNKNDCIMPKVLPVLELAIRHVQ-RMGFVGGSHFDIQLISRDTFCSSKYGPIGFFE 152
            :.|||   .||.....|.:|.|.::.|:|.:| ....:.|.||::  |..|:.|.:: ......:
Frog    30 LVLLP---KDNSYMFSMDRVRPAVDHALRSIQENQTLLPGMHFNV--IYNDSDCGNQ-ALFSLID 88

  Fly   153 IYTQWPEVNAVFGLPCEYVLAPISRYADVWQVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNNL 217
            |..|..:.:.:.|..|||..||::|.|..|.||:|:.|..|..|.:||..||.|||:... .:.:
Frog    89 IAMQLQKPDVILGPVCEYAAAPVARLASHWNVPMLSAGALAIGFMQKSNEYSHLTRVSPV-YSKM 152

  Fly   218 GNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTWTK-ADI 281
            |.:..|:.....||:..|:|.::|.:..    ||..|..:|...:|.. |.:.......|| .|.
Frog   153 GEMFLAMFRYHKWTKAFLLYTDDNLQRN----CFFTLEGVHLAFKEEG-YAMSIHNFDETKHVDA 212

  Fly   282 TRMLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWY--DK 344
            ..::.::..:.|:|||||...::|.|||.|....| .:|:|||.|||||:...| .:..|.  ||
Frog   213 EEIVHSIQNKERVVIMCASSDTVRNIMLAAHRQGM-TNGDYVFFNIELFNSSTY-GNGSWKRGDK 275

  Fly   345 NDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDG 409
            .|.:     |::||:::.|||..:....|:.:.|.|:|: :.:|..  .::::.::.||..|.|.
Frog   276 YDLE-----AKQAYSSLQTVTLLRTVKPEFEKFSMEVKS-SVQKLG--LNEDDYVNMFVEGFHDA 332

  Fly   410 VLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDM-NPT 473
            ::|||.||:|.::...:..    :|..:|::||||::.||.|.|:|||||||...:|::.| :..
Frog   333 IILYALALHELLKNGFSKK----DGEKLVQQMWNRTYEGIAGQVSIDANGDRYGDFSVIAMTDKE 393

  Fly   474 TGRFEIVAHF--LHNRLEFEANKEIHWAGDR-------EEAPPDRPICGYDGALCPDNSLPGYAI 529
            ||..|::..:  :....|...|.:..|...|       .|.|...| |...|.|...      |:
Frog   394 TGTQEVIGDYYGIQGHFEIRPNVKPPWGPGRLLINERIVEHPSTTP-CKSSGGLGES------AV 451

  Fly   530 LSIVLGTMV---VVMAVCFF 546
            ..||:|..:   ::||..||
Frog   452 TGIVVGAFLGTGLLMAFYFF 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	128/415 (31%)
		ANF_receptor	108..473	CDD:279440	117/369 (32%)
		PK_GC-A_B	589..883	CDD:270944
		Pkinase_Tyr	613..877	CDD:285015
		HNOBA	<893..938	CDD:285003
		CYCc	917..1108	CDD:214485
		Guanylate_cyc	944..1130	CDD:278633
npr3	XP_004910476.1	PBP1_NPR_C	25..414	CDD:380609	127/409 (31%)
npr3	XP_004910476.1	TM_EphA1	443..474	CDD:391457	10/35 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910