DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and LOC100489435

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	XP_017947350.2	Gene:	LOC100489435 / 100489435	-ID:	-	Length:	1106	Species:	Xenopus tropicalis

Alignment Length:	1189	Identity:	381/1189 - (32%)
Similarity:	564/1189 - (47%)	Gaps:	266/1189 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 RRLGARRQ------------LVFVALLPSVESDNKN-----------DCIMPKVLPVL--ELAIR 117
            |||.|:|.            |:....:.|:..|.||           |.:..|..|.|  .||::
Frog    20 RRLCAKRPTRTFPFSIPSWWLLMGVFMNSLGVDCKNFTVGVVGPWQCDPLFSKAFPELAARLAVQ 84

  Fly   118 HVQRMGFVG-GSHFDIQLI--------------SRDTFCSSKYGPI--GFFEIYT----QWPEVN 161
            .:.....:| |..||.:::              |.|...|:..||:  |:.:..|    .|.:
Frog    85 KINNDATLGIGYKFDYRILQENCETSKALVDFSSYDKHSSAFVGPMNPGYCDAATLLGKNWDK-- 147

  Fly   162 AVFGLPCEYVLAPISRYADVWQVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILN 226
            |||...|      |:.                 :.:.|| |:.|..|...|..    .|:...:.
Frog   148 AVFSWAC------INH-----------------DLDDKS-SFPTFARTMPAPT----KVLFHFMK 184

  Fly   227 SFNWTRTALIYQNENAKV-KGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTWT-KADITRMLKNV- 288
            .|.|....::..|::..| .|..|.        ..:..|.: .:|..||... :..:...|.|:
Frog   185 YFRWAHVGIVSSNDDLWVDTGRKVA--------SALRNHGL-PIGIVTSMGNGEEGLRATLANIE 240

  Fly   289 -AMQSRIVIMCADPQSI----RQIMLT-AEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDT 347
             |...|::|||.....|    :...|| |.|:.:.| |.|||:..:..     |.|.|:.:.:..
Frog   241 EAHDLRVIIMCMHSVLIGGAEQATFLTQAHEMGLTD-GRYVFVPYDTL-----LYSLPYKNSSYQ 299

  Fly   348 DL-NNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNY-TFSDNEPISAFVTSFFDGV 410
            .| .|...:.||.|:||:|....|.:.|     |:.|.|.|:... |..:.:.:|....:.::.:
Frog   300 VLEKNPELKAAYDAVLTITMDYENLSFY-----EVFAEAKERGEIKTSVEPQQVSPLFGTIYNAM 359

  Fly   411 LLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTG 475
            .|.|.|::.:.::...     ::||::|....|..:.|.|..:..|..|:.||.:.:||   |.|
Frog   360 YLLAKAMSSAWKQGAW-----VSGTNLVDYAKNLEYPGFTQTLYTDGKGNDLSNFVVLD---TDG 416

  Fly   476 RFEIVAHFLHNRLEFEAN------KEIHWAGDREEAPPDRPICGYD-GALCPDNSLPGYAILSIV 533
            :...:  |....:|..:|      |.|.:.|.  ..||....|.:| ..||.....|...||  :
Frog   417 KVNQL--FPTYSVEMSSNLVRFLGKTIRFPGG--TPPPSDSSCWFDPDTLCIGGIEPYIVIL--I 475

  Fly   534 LGTMVVVMAVC---FFFGYRHYIAEAEINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQSSQLT 595
            .| :|..:|:|   ..:..||.|.:.:                             |||..:::.
Frog   476 FG-LVFALALCGVVVSYLIRHSILQIQ-----------------------------LVKGPNKIL 510

  Fly   596 LMSEDMVSINGDRQIFIPVGMFRKSKVAIKPVEVDNVQGL-----------LTRSLMLE------ 643
            |..:|:..||              .|:::|.:.:||:...           |||||..:
Frog   511 LSLDDLTFIN--------------PKLSMKKLNIDNISDTKSISDCKSLKSLTRSLSAKSLGASH 561

  Fly   644 ---------------------------------LKRMKDLQHDHLVKFYGACLDQRRSFLLTEYC 675
                                             |::||||:::::..|.|...|.....::||:|
Frog   562 ETSSVAIYEGDWVWLKKFEPGVYHELRQSTTSTLRKMKDLRNENVNPFLGFFSDCGIFAIVTEHC 626

  Fly   676 PKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFG 740
            .:|||:|:|.||..:|||||:.||:.|:::||::||..|. |||.|||.|||||.||||||||:|
Frog   627 SRGSLEDLLRNEDVKLDWMFKSSLLLDLIKGMRYLHHRDF-SHGRLKSRNCVVDGRFVLKITDYG 690

  Fly   741 ----LHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEI 801
                :.|.:..|:.:..:           :|.|||||||| :......||.||||::|.||:.|:
Frog   691 YNEVVETQKSPRYSMPPE-----------ELFWTAPELLR-DQALSRRGTFKGDVFSFAIILQEV 743

  Fly   802 TTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKP---FRPELEPNGDTKADINGIIRRCWAED 863
            ..| ||.|   |....|.:|||..||        ||   .||.:.|: ....:...::::||:|.
Frog   744 VVR-GPPY---CTSGLSAEEIIRKVK--------KPPPLCRPAVAPD-QAPLECIQLMKQCWSEL 795

  Fly   864 PAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQ 928
            ...||.|:.:....:..||..:| ||:|::|:.:|.|::|||:|:.|||::...||:|.||||.|
Frog   796 AERRPTFDEIFDQFKTINKGKKT-NIIDSMLRMLEQYSSNLEDLIRERTEELEVEKQKTEKLLSQ 859

  Fly   929 LLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFD 993
            :||.|||..|.:|..|..|.||.||||||||||||.|||.|.|::||..||||||.||:::.|.|
Frog   860 MLPPSVAEALKTGGTVEPEYFDHVTIYFSDIVGFTTISALSEPIEVVDLLNDLYTLFDAVLCNHD 924

  Fly   994 VYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACV 1058
            |||||||||||||.||||.||||:|..|||.::|.:|.:|.:|::.|.|:..:::|||||:|.||
Frog   925 VYKVETIGDAYMVASGLPKRNGNRHTAEIANMSLDILSSVGSFQMRHMPDVPVRIRIGLHSGPCV 989

  Fly  1059 AGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFG-TFVTTRRGFVPMKGKGE 1122
            ||||||.|||||||||||||||||||.|...:||::::|...|.... .:....||...:||||.
Frog   990 AGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNQSTAAILRTLNERYKIELRGKTELKGKGV 1054

  Fly  1123 MLTYWLEGE------VPRP 1135
            ..|:||.|:      :|||
Frog  1055 EETFWLVGKEGFSKPLPRP 1073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	102/460 (22%)
		ANF_receptor	108..473	CDD:279440	89/398 (22%)
		PK_GC-A_B	589..883	CDD:270944	109/350 (31%)
		Pkinase_Tyr	613..877	CDD:285015	103/320 (32%)
		HNOBA	<893..938	CDD:285003	23/44 (52%)
		CYCc	917..1108	CDD:214485	117/191 (61%)
		Guanylate_cyc	944..1130	CDD:278633	111/186 (60%)
LOC100489435	XP_017947350.2	PBP1_sensory_GC_DEF-like	57..438	CDD:380594	96/440 (22%)
		PK_GC-2D	550..815	CDD:270945	98/290 (34%)
		HNOBA	<824..869	CDD:400168	23/44 (52%)
		CYCc	849..1041	CDD:214485	117/191 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010