DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and npr2

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	XP_009300100.1	Gene:	npr2 / 100331745	ZFINID:	ZDB-GENE-141030-2	Length:	1048	Species:	Danio rerio

Alignment Length:	1109	Identity:	475/1109 - (42%)
Similarity:	650/1109 - (58%)	Gaps:	129/1109 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 RLGARRQLVFVALLPSV-------ESDNKNDCIM-----------PKVLPVLELAIRHVQRMGFV 125
            ::|.|   ||:.||..:       |..|....:|           |:|||.:.:|...:|:.|.:
Zfish     6 KMGYR---VFIVLLTRMVVLECRAEKGNITVAVMLPENLKYSWASPRVLPAIRMAQEKIQKSGLL 67

  Fly   126 GG-----------------SHFDIQLISRDTFCSSKYGPIGFFEIYTQWPEVNAVFGLPCEYVLA 173
            .|                 |..:.|:|:.||            ::|.: |:  |..|..|.|.:|
Zfish    68 RGHTINLLNFSTEDSSGSCSENEAQIIAVDT------------KLYHK-PD--AFIGPGCTYSVA 117

  Fly   174 PISRYADVWQVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTALIYQ 238
            .:.|:|..|::|::|.||.|..|: |.|.:.|:.| .|.....||:.|..:...|||:..||:..
Zfish   118 SVGRFASHWKLPLITAGGPAYGFD-KWEEFKTIVR-TGPTTKKLGDFVNYLHGQFNWSSRALMIF 180

  Fly   239 NENAKVKGNSVCFLCLAAIHDTIEEHSVYQLGF---DTSTWTKADITRMLKNVAMQSRIVIMCAD 300
            :: .|.......||. ..|:..:.|.::..|.|   |..|:...|:...:|:   ..|||.:|..
Zfish   181 HD-LKQDDRPHYFLS-EGIYTVLREENITVLAFPYEDEQTYNYKDMITFIKD---NGRIVYICGP 240

  Fly   301 PQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTS---QPWYDKNDTDLNNERAQKAYTAML 362
            ..:..|||...|: .:....:|....:::|:  :.|:.   .||   ..:|:......|.:.::.
Zfish   241 LPTFFQIMKLFED-EVKSPEDYAIFYLDVFA--ESLSGDVPMPW---QGSDIQWNDPIKLFQSVF 299

  Fly   363 TVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEP-ISAFVTS-FFDGVLLYANALNESIREDP 425
            .||.::|:..|||....|:...|.:.:|...   || :..|:.. |.||.:|||.||:|::.:..
Zfish   300 VVTYQEPDSPEYTAFRKELHKRAIQDFNVQL---EPSMMDFIAGCFHDGFVLYAKALSEALADGV 361

  Fly   426 TMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDM-NPTTGRFEIVAHFLHNRLE 489
            :.    .:|.::..||.||...|:||.|:||....|.:.:||..| |..:|::.||.|:
Zfish   362 SQ----NDGINITARMQNRRLWGVTGLVSIDQKNARFTDFSLWAMTNLKSGQYAIVGHY------ 416

  Fly   490 FEANKEIHWAGDR-----EEAPP-DRPICGYDGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFG 548
            ...:|||.|:...     :..|| |.|.||:  :.|.::.||...|:::..|..:::..:..|..
Zfish   417 NGTSKEILWSPTEKIQWPKGCPPLDYPPCGF--SPCKEDHLPVLGIVAVGSGLALIIFGISSFLI 479

  Fly   549 YRHYIAEAEINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQSSQLTLMSE-----DMVSINGDR 608
            ||....|.|:..|.|::..|::.|...      ..:|.  :..|:|||...     .:::.:|..
Zfish   480 YRKLKLEKELAGMLWRIRWEELQFESP------NKYHK--RAGSRLTLSQRGSSYGSLITAHGKY 536

  Fly   609 QIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTE 673
            |:|...|.|:.:.||||.|....::  |||.::.|||.|:|:|.:||.:|.|||:|.....::||
Zfish   537 QLFAKTGYFKGNLVAIKHVNKKRIE--LTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTE 599

  Fly   674 YCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITD 738
            |||:||||||||||...||||||.||::|||:||.:||:|.|.||||||||||||||||||||||
Zfish   600 YCPRGSLQDILENESINLDWMFRYSLINDIVKGMNYLHNSYIGSHGNLKSSNCVVDSRFVLKITD 664

  Fly   739 FGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITT 803
            :||.:.|       |...|.:|||.::|.|||||||| :....||:||||||||:||||:.||..
Zfish   665 YGLASFR-------SSCENEDSHALYAKKLWTAPELL-IYDRHPPQGTQKGDVYSFGIILQEIAL 721

  Fly   804 RQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKP-FRPELEPNGDTKADINGIIRRCWAEDPAER 867
            |.||||:.  ..:.||:|||:.|:     ..||| |||..: |.....::..::..||:||||||
Zfish   722 RNGPFYVE--GMDLSPKEIIQKVR-----NGQKPYFRPTTD-NSRHCEELTILMEGCWSEDPAER 778

  Fly   868 PDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQ 932
            |||:.:|..|.:|||:..| :|::.||.|||.||||||.|||||||.|.|||:|.|.||||:||.
Zfish   779 PDFSHIKVFIAKFNKEGST-SILNXLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPH 842

  Fly   933 SVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKV 997
            |||.||..|:.|.||.||.||||||||||||::||||||:|||..|||||||||:|::|||||||
Zfish   843 SVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKV 907

  Fly   998 ETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVV 1062
            ||||||||||||||:|||..||||||.::|||||.|..|:|.|||.|:|:||||:|||...||||
Zfish   908 ETIGDAYMVVSGLPVRNGKLHAREIAGMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVV 972

  Fly  1063 GLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYW 1127
            ||||||||||||||||||||||.||||:||:|..|||.|||||.|....||.|.|||||:|.|||
Zfish   973 GLKMPRYCLFGDTVNTASRMESTGEALRIHMSSATKEVLDEFGYFELQLRGDVEMKGKGKMRTYW 1037

  Fly  1128 LEGE 1131
            |.||
Zfish  1038 LLGE 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	118/453 (26%)
		ANF_receptor	108..473	CDD:279440	104/390 (27%)
		PK_GC-A_B	589..883	CDD:270944	150/299 (50%)
		Pkinase_Tyr	613..877	CDD:285015	140/264 (53%)
		HNOBA	<893..938	CDD:285003	33/44 (75%)
		CYCc	917..1108	CDD:214485	144/190 (76%)
		Guanylate_cyc	944..1130	CDD:278633	141/185 (76%)
npr2	XP_009300100.1	Periplasmic_Binding_Protein_Type_1	32..426	CDD:299141	113/434 (26%)
		ANF_receptor	49..403	CDD:279440	102/388 (26%)
		PK_GC-A_B	520..794	CDD:270944	146/291 (50%)
		HNOBA	<803..848	CDD:285003	33/44 (75%)
		CYCc	827..1019	CDD:214485	145/191 (76%)
		Guanylate_cyc	854..1040	CDD:278633	141/185 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582917
Domainoid	1	1.000	292	1.000	Domainoid score	I1494
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	784	1.000	Inparanoid score	I500
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	1	1.000	-	-		FOG0002376
OrthoInspector	1	1.000	-	-		otm25592
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2472
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.800