DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and gucy1b1

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_001238874.1	Gene:	gucy1b1 / 100150304	ZFINID:	ZDB-GENE-090313-160	Length:	608	Species:	Danio rerio

Alignment Length:	593	Identity:	174/593 - (29%)
Similarity:	245/593 - (41%)	Gaps:	176/593 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   632 VQGLLTRSLMLELKRMKDLQHDHLVKFYGA-------CLDQRR--SFLLTEYCPKGSLQDILENE 687
            |.|...|..:..|    |..||||...|..       |.|..:  :.:|..|..:..||||:
Zfish    89 VLGSNVREFLQNL----DALHDHLGTIYPGMRAPSFRCTDAEKGNNLILHYYSEREGLQDIV--- 146

  Fly   688 QFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHG-NLKSSNCVVDS-RFVLKITDFGLHTLRRTRFD 750
                     :.::..:.   |.:|.::|.... ..||..|  |. :|:::
Zfish   147 ---------IGIIKTVA---QQIHGTEIEMKVIQPKSEEC--DHIKFLIE--------------- 182

  Fly   751 LESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDV--YAFGIIVHEITTRQGPFYL--- 810
             |.|.   ...|::.       :|...|.|    |||:..:  |.|        .:..||:|
Zfish   183 -EKDS---EEEAFYE-------DLDGFEEN----GTQETRISPYTF--------CKAFPFHLMFD 224

  Fly   811 --------GRCAYEKSPQ---------EIIELVKGYNPHRMQKPFRPELEPNGDTKADINGI--- 855
                    |...:...||         .:..||:   || :...|...|       :.||.:
Zfish   225 KDLMLTQCGNAIFRVLPQLQPGVCNLSSVFSLVR---PH-IDFSFHGIL-------SHINTVFVL 278

  Fly   856 --------IRRCWAEDPAERPDFNTLK---SMIRRFNKDNETGNI-------VDNL--LKRMELY 900
                    :.....||.....:.:.|:   .||..    .||.||       |.||  |.|..||
Zfish   279 RSKEGLLNVETAENEDELTGTEISCLRLKGQMISL----PETENILFLCSPSVMNLDDLTRRGLY 339

  Fly   901 ANNLE-------------------------ELVEERTQD----YHEEKKKCEKLLYQLLPQSVAA 936
            .:::.                         |::.:|.|.    ..:||||.::|||.:||.|||.
Zfish   340 LSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQHTLRALEDEKKKTDRLLYSVLPPSVAN 404

  Fly   937 QLISGQPVVAETFDQVTIYFSDIVGFTAI-----SAESTPMQVVQFLNDLYTCFDSIVE---NFD 993
            :|...:||.|:.:|.|||.||.||||.|.     |||.. :::|..|||:||.||.:.:   |..
Zfish   405 ELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASAEGA-IKIVNLLNDIYTRFDILTDSRKNPY 468

  Fly   994 VYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACV 1058
            ||||||:||.||.||||| .....||:.|..|||.::|.....::   .||.:::.||:|||..|
Zfish   469 VYKVETVGDKYMTVSGLP-EPCTHHAKSICHLALDMMEIAGQVKV---DEDPVQITIGIHTGEVV 529

  Fly  1059 AGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGT----FVTTRRGFVPMKG 1119
            .||:|.:||||||||:|||..||.|:.||..||::||.|...|.....    |....||.|.|||
Zfish   530 TGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLQSVENADPQFHLEYRGPVTMKG 594

  Fly  1120 KGEMLTYW 1127
            |.|.:..|
Zfish   595 KKEPMKVW 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944	56/297 (19%)
		Pkinase_Tyr	613..877	CDD:285015	54/291 (19%)
		HNOBA	<893..938	CDD:285003	20/75 (27%)
		CYCc	917..1108	CDD:214485	94/202 (47%)
		Guanylate_cyc	944..1130	CDD:278633	90/196 (46%)
gucy1b1	NP_001238874.1	HNOB	2..166	CDD:285002	21/95 (22%)
		HNOBA	207..406	CDD:285003	47/221 (21%)
		CYCc	385..584	CDD:214485	95/203 (47%)
		Guanylate_cyc	412..605	CDD:278633	90/196 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810