Protein Alignment Hmt-1 and ATM1

DIOPT Version :10

• Sequence 1: NP_650503.1
• Gene: Hmt-1 / 41925
• FlyBaseID: FBgn0038376
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_014030.1
• Gene: ATM1 / 855347
• SGDID: S000004916
• Length: 690
• Species: Saccharomyces cerevisiae
• Alignment Length: 621
• Identity: 251/621 - (40%)
• Similarity: 366/621 - (58%)
• Gaps: 62/621 - (9%)

  Fly   232 LRTVFPYLWPKKNIALQIAVIVCIILLLAGRVIKLFLPIYRKKLVDSLTIAPIVFRWD------- 289
            |:.:|.|:|||.|..::|.|::.:.||::.:::.:.:|.:.|:.:||:.||     ||
Yeast    92 LKDLFRYIWPKGNNKVRIRVLIALGLLISAKILNVQVPFFFKQTIDSMNIA-----WDDPTVALP 151

  Fly   290 -----FVLIYVALSFLQGGGTGSMGLFNNLRTFLWIRVQQYTTREIEIELFRHLHQLSLRWHLQR 349
                 .:|.|....|      ||: ||..||..::.:|.|...|.:.::.|:||.:|.|.|||.|
Yeast   152 AAIGLTILCYGVARF------GSV-LFGELRNAVFAKVAQNAIRTVSLQTFQHLMKLDLGWHLSR 209

  Fly   350 KTGEVLRVMDRGTDSINNLLNYIVFSIAPTILDLLVAVAYFVYAFNWWFGLIVFLTMFLYIASTI 414
            :||.:.|.|||||..|:.:|..:||.|.|...::.|......|.|...|..|.|.||.||...||
Yeast   210 QTGGLTRAMDRGTKGISQVLTAMVFHIIPISFEISVVCGILTYQFGASFAAITFSTMLLYSIFTI 274

  Fly   415 AITEWRTKYQRRMNLADNEQRARSVDSLLNFETVKYYGAEHYEVDCYREAILKYQKEEFLSMLTL 479
            ..|.|||.::|..|.|||:..:.::|||:|||.|||:..|.|..|.|..:::.|:..:.....:|
Yeast   275 KTTAWRTHFRRDANKADNKAASVALDSLINFEAVKYFNNEKYLADKYNGSLMNYRDSQIKVSQSL 339

  Fly   480 NMLNTAQNIIL-----------CLGLLAGSLLCVYLVVHHQTLTVGDFVLFSTYLMELYMPLNWF 533
            ..||:.||:|.           |.|::.|:            |||||.||.:..:.:|.:|||:.
Yeast   340 AFLNSGQNLIFTTALTAMMYMGCTGVIGGN------------LTVGDLVLINQLVFQLSVPLNFL 392

  Fly   534 GTYYRAIQKNFVDMENMFDLLKEEEEIVDAPGCSPLLTAGG---GIEFSNVTFGYSPEKIVLRNV 595
            |:.||.::::.:|||.:|.|.|.|.:|.:|.  .||:....   .|.|.||||||.|::.:|:|.
Yeast   393 GSVYRDLKQSLIDMETLFKLRKNEVKIKNAE--RPLMLPENVPYDITFENVTFGYHPDRKILKNA 455

  Fly   596 SFTVPAGKTVAIVGPSGAGKSTIMRLLFRFYDVQTGAILIDGQNIKLVQQQSLRKAIGVVPQDTV 660
            |||:|||...||||.||:|||||::|:|||||.::|.|||:|::||.....:|||.||||||||.
Yeast   456 SFTIPAGWKTAIVGSSGSGKSTILKLVFRFYDPESGRILINGRDIKEYDIDALRKVIGVVPQDTP 520

  Fly   661 LFNNTIFYNIEYAKLGASDEAVYEAARAADIHERILGFPEKYETKVGERGLRLSGGEKQRVAIAR 725
            |||:||:.|:::.::.|:||.|......|.:...|...|:.::|.||||||.:|||||||:||||
Yeast   521 LFNDTIWENVKFGRIDATDEEVITVVEKAQLAPLIKKLPQGFDTIVGERGLMISGGEKQRLAIAR 585

  Fly   726 TLLKAPIIVLLDEATSALDTHTERNIQAALARVCAN-----RTTIIVAHRLSTIIHADEILVLQQ 785
            .|||...|:..||||||||||||   ||.|..:..|     ||::.:||||.||..||:|:||..
Yeast   586 VLLKNARIMFFDEATSALDTHTE---QALLRTIRDNFTSGSRTSVYIAHRLRTIADADKIIVLDN 647

  Fly   786 GSIAERGRHEELVLREDGIYADMW--QQQLKNLDAE 819
            |.:.|.|:|.||:.....:|.::|  |:.|.:|:.|
Yeast   648 GRVREEGKHLELLAMPGSLYRELWTIQEDLDHLENE 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmt-1	NP_650503.1	MTABC_N	3..241	CDD:465049	3/8 (38%)
		ATM1	222..821	CDD:444078	251/621 (40%)
ATM1	NP_014030.1	ATM1	81..674	CDD:444078	247/610 (40%)