Protein Alignment Hmt-1 and ABCB4

DIOPT Version :10

• Sequence 1: NP_650503.1
• Gene: Hmt-1 / 41925
• FlyBaseID: FBgn0038376
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_182223.1
• Gene: ABCB4 / 819314
• AraportID: AT2G47000
• Length: 1286
• Species: Arabidopsis thaliana
• Alignment Length: 659
• Identity: 196/659 - (29%)
• Similarity: 298/659 - (45%)
• Gaps: 149/659 - (22%)

  Fly   234 TVFPYLWPKKNIALQIA---------------------VIVCIILLLAGRVIKLFL--PIYRKKL 275
            |..|...|||....:||                     ||:.|..:|...|||.|.  |   |||
plant   694 TTQPKTEPKKVSIFRIAALNKPEIPVLILGSISAAANGVILPIFGILISSVIKAFFQPP---KKL 755

  Fly   276 VDSLTIAPIVFR---WDFVLIYVALSFLQGGGTGSMGLFNNLRTFLWIRVQQYTTREIEIELFRH 337
            .:..:...|:|.   :..::.|.|                  :||.:........:.|....|..
plant   756 KEDTSFWAIIFMVLGFASIIAYPA------------------QTFFFAIAGCKLVQRIRSMCFEK 802

  Fly   338 LHQLSLRW--HLQRKTGEVLRVMDRGTDSINNLLNYIVFSIAPTILDLLVAVAYFVYAF--NWWF 398
            :..:.:.|  ..:..:|.:...:.....:|..|:.   .|:|.|:.:|...:|..:.||  .|..
plant   803 VVHMEVGWFDEPENSSGTIGARLSADAATIRGLVG---DSLAQTVQNLSSILAGLIIAFLACWQL 864

  Fly   399 GLIVF-------LTMFLYIASTIAITEWRTKYQRRMNLADNEQ---RARSV--DSLLNFETVKYY 451
            ..:|.       |..|||:           |:.:..: ||.::   .|..|  |::.:..||..:
plant   865 AFVVLAMLPLIALNGFLYM-----------KFMKGFS-ADAKKMYGEASQVANDAVGSIRTVASF 917

  Fly   452 GAEHYEVDCYREAILKYQKEEFLSMLTLNMLNTAQNIILCLGLLAGSLLCVYLVVHHQTLTVGDF 516
            .||...::.|.:......|.           ...|.|:..:|                 .....|
plant   918 CAEDKVMNMYSKKCEGPMKN-----------GIRQGIVSGIG-----------------FGFSFF 954

  Fly   517 VLFSTYLMELYMPL-------NWFGTYYRAI--------------------QKNFVDMENMFDLL 554
            ||||:|....|:..       ..|.:.:|..                    .|..|...::|.::
plant   955 VLFSSYAASFYVGARLVDDGKTTFDSVFRVFFALTMAAMAISQSSSLSPDSSKADVAAASIFAIM 1019

  Fly   555 KEEEEIVDAPGCSPLLTAG-------GGIEFSNVTFGY--SPEKIVLRNVSFTVPAGKTVAIVGP 610
            ..|.:|      .|.:.:|       |.||..:|:|.|  .|:..:.:::..::.||||||:||.
plant  1020 DRESKI------DPSVESGRVLDNVKGDIELRHVSFKYPARPDVQIFQDLCLSIRAGKTVALVGE 1078

  Fly   611 SGAGKSTIMRLLFRFYDVQTGAILIDGQNIKLVQQQSLRKAIGVVPQDTVLFNNTIFYNIEYAKL 675
            ||:||||::.||.||||..:|.|.:||..||.::.:.||:..|:|.|:.:|||.||..||.|.|.
plant  1079 SGSGKSTVIALLQRFYDPDSGEITLDGVEIKSLRLKWLRQQTGLVSQEPILFNETIRANIAYGKG 1143

  Fly   676 G-ASDEAVYEAARAADIHERILGFPEKYETKVGERGLRLSGGEKQRVAIARTLLKAPIIVLLDEA 739
            | ||:..:..:|..::.|..|.|..:.|:|.|||||::||||:||||||||.::|.|.::|||||
plant  1144 GDASESEIVSSAELSNAHGFISGLQQGYDTMVGERGIQLSGGQKQRVAIARAIVKDPKVLLLDEA 1208

  Fly   740 TSALDTHTERNIQAALARVCANRTTIIVAHRLSTIIHADEILVLQQGSIAERGRHEELVLREDGI 804
            |||||..:||.:|.||.||..|||||:||||||||.:||.|.|::.|.|.|:|:|:.|:..:||:
plant  1209 TSALDAESERVVQDALDRVMVNRTTIVVAHRLSTIKNADVIAVVKNGVIVEKGKHDTLINIKDGV 1273

  Fly   805 YADMWQQQL 813
            ||.:.|..|
plant  1274 YASLVQLHL 1282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmt-1	NP_650503.1	MTABC_N	3..241	CDD:465049	2/6 (33%)
		ATM1	222..821	CDD:444078	196/659 (30%)
ABCB4	NP_182223.1	PTZ00265	46..1280	CDD:240339	194/655 (30%)
		MdlB	705..1285	CDD:440747	191/648 (29%)