DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hmt-1 and abcb6

DIOPT Version :9

Sequence 1:NP_650503.1 Gene:Hmt-1 / 41925 FlyBaseID:FBgn0038376 Length:866 Species:Drosophila melanogaster
Sequence 2:NP_001072643.1 Gene:abcb6 / 780100 XenbaseID:XB-GENE-1001119 Length:849 Species:Xenopus tropicalis


Alignment Length:875 Identity:460/875 - (52%)
Similarity:611/875 - (69%) Gaps:49/875 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 YCPPNVTLSEVWTQHGISHCFMDTVGPAVYGGFLLLFGSIQLLMYRKYATRITDPTQISKSRLFA 67
            ||..|.::|:.|...|:|.||..|:.|:|...|..|.|::|..:|.:::|.: :|..|.:|||:.
 Frog     7 YCEHNGSISQAWLDSGLSPCFYFTLVPSVLLSFSFLLGALQSALYARHSTTM-EPKYIPRSRLYR 70

  Fly    68 MQLFLLLLLPVLALLRFLMNARIYPDSAVYGYMIFSTCVVCFSYPFSICLILKERYYQLPSMPTR 132
            :|:.|.::|.:.:::..:..|.  ....||||||...|:...::.||:.|:..||...|....:|
 Frog    71 LQIVLSVVLILQSVIGLIWQAA--GTDVVYGYMIVHGCLSVVAWGFSLWLLHLERTRALVREKSR 133

  Fly   133 GHGLVLLLFWTLAFINESLAFINLRHEDWWFHLK-TNKDQIEMGLFVTRFLCSLLIFVLGLKAPG 196
            |||:||||||.|||..|:||||:.:..:||:..: |...:::.||::||::|:|.:||||::|||
 Frog   134 GHGVVLLLFWALAFAAENLAFISWQSPNWWWLSRDTVPQKVQFGLWITRYVCTLFLFVLGIRAPG 198

  Fly   197 IMAPYNPHQRLDNDTANESQGNVQTGSAF-----RNGW----RKLRTVFPYLWPKKNIALQIAVI 252
              .|..|:..|    .||.:.:|:|....     ::.|    :||..|..|:||::||.||:.|.
 Frog   199 --RPRKPYIVL----INEDERDVETSQPLLRDPNQSTWQGFKKKLLLVMQYIWPRRNIPLQLLVA 257

  Fly   253 VCIILLLAGRVIKLFLPIYRKKLVDSLTIAPIVFRWDF----VLIYVALSFLQGGGTGSMGLFNN 313
            :|:.|:...|.|.:|:|||.||:||.||...   .|:.    |.|||.|.||||||.|:.|..:|
 Frog   258 LCMGLMGLERAINVFVPIYAKKIVDGLTEDS---TWNILAVTVCIYVLLKFLQGGGAGTTGFLSN 319

  Fly   314 LRTFLWIRVQQYTTREIEIELFRHLHQLSLRWHLQRKTGEVLRVMDRGTDSINNLLNYIVFSIAP 378
            ||||:||||||:|.||::|.||.|||.|||||||.||||||||.:||||.|||:||:||||||.|
 Frog   320 LRTFMWIRVQQFTNREVQIRLFAHLHSLSLRWHLGRKTGEVLRSVDRGTSSINSLLSYIVFSILP 384

  Fly   379 TILDLLVAVAYFVYAFNWWFGLIVFLTMFLYIASTIAITEWRTKYQRRMNLADNEQRARSVDSLL 443
            ||.|:::.:.||..:||.|||||:|:.|.||:..||.||||||||:|.||..|||.::|:|||||
 Frog   385 TIADIVIGIVYFTSSFNAWFGLIIFVCMTLYLTLTIIITEWRTKYRREMNTRDNEAKSRAVDSLL 449

  Fly   444 NFETVKYYGAEHYEVDCYREAILKYQKEEFLSMLTLNMLNTAQNIILCLGLLAGSLLCVYLVVHH 508
            ||||||||.||.|||..:.::|:|||..|:....:|.|||..||:|:.||||||||||.|.|..:
 Frog   450 NFETVKYYNAEGYEVGRFNDSIMKYQVSEWKVNASLAMLNQTQNLIIGLGLLAGSLLCAYFVTEN 514

  Fly   509 QTLTVGDFVLFSTYLMELYMPLNWFGTYYRAIQKNFVDMENMFDLLKEEEEIVDAPGCSPLLTAG 573
            : ..|||:|||.||:::||.||||||||||.||.:|:||||||:|..|::|:.||.....|:...
 Frog   515 K-FKVGDYVLFGTYIIQLYTPLNWFGTYYRMIQSSFIDMENMFELFNEDQEVKDAVNAPALMFRS 578

  Fly   574 GGIEFSNVTFGYSPEKIVLRNVSFTVPAGKTVAIVGPSGAGKSTIMRLLFRFYDVQTGAILIDGQ 638
            |.|||.||.|.|...|.:||::||||..|:::|:|||||:|||||:|||||||||:.|.|.:|||
 Frog   579 GKIEFENVHFSYLDGKEILRDISFTVMPGQSIALVGPSGSGKSTIIRLLFRFYDVKGGTIKVDGQ 643

  Fly   639 NIKLVQQQSLRKAIGVVPQDTVLFNNTIFYNIEYAKLGASDEAVYEAARAADIHERILGFPEKYE 703
            :|..|:|:|||..||||||||||||:||..||.|.::.|:|:.|.|||.|||||||||.|.:.|:
 Frog   644 DISTVRQESLRSHIGVVPQDTVLFNDTIRNNIRYGRVSATDDEVEEAAAAADIHERILSFRDGYD 708

  Fly   704 TKVGERGLRLSGGEKQRVAIARTLLKAPIIVLLDEATSALDTHTERNIQAALARVCANRTTIIVA 768
            |:.|||||:||||||||||||||:||||.|:|||||||||||.|||||||:||:||||||||:||
 Frog   709 TQTGERGLKLSGGEKQRVAIARTILKAPQIILLDEATSALDTETERNIQASLAKVCANRTTIVVA 773

  Fly   769 HRLSTIIHADEILVLQQGSIAERGRHEELVLREDGIYADMWQQQLKNLDAEQSGGSDNGDASAE- 832
            |||||:|::|:||||::|.|.||||||||:|: .|:||.|||:|       |||...:.|:.:| 
 Frog   774 HRLSTVINSDQILVLKEGQIVERGRHEELLLK-GGVYAGMWQKQ-------QSGSESSSDSDSER 830

  Fly   833 --SGSEKRRAGGAGGPSGTGTGGAHFRAGH 860
              ..|||.:.     |..|.      |.||
 Frog   831 KDRTSEKLQP-----PKATP------RRGH 849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hmt-1NP_650503.1 MTABC_N 3..241 CDD:292803 86/247 (35%)
ABC_membrane 255..530 CDD:279056 163/278 (59%)
ATM1 314..811 CDD:227590 323/496 (65%)
ABCC_ATM1_transporter 576..812 CDD:213220 163/235 (69%)
abcb6NP_001072643.1 Required for ATPase activity. /evidence=ECO:0000250|UniProtKB:Q9NP58 1..227 81/228 (36%)
Required for the lysosomal targeting. /evidence=ECO:0000250|UniProtKB:Q9NP58 1..195 71/190 (37%)
MTABC_N 6..246 CDD:318426 86/247 (35%)
ATM1 320..815 CDD:227590 323/496 (65%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 814..849 13/52 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 327 1.000 Domainoid score I1180
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H11375
Inparanoid 1 1.050 870 1.000 Inparanoid score I411
OMA 1 1.010 - - QHG54509
OrthoDB 1 1.010 - - D248727at2759
OrthoFinder 1 1.000 - - FOG0004593
OrthoInspector 1 1.000 - - otm48742
Panther 1 1.100 - - LDO PTHR24221
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3271
SonicParanoid 1 1.000 - - X3206
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1313.110

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