Protein Alignment Hmt-1 and Abcb6

DIOPT Version :10

• Sequence 1: NP_650503.1
• Gene: Hmt-1 / 41925
• FlyBaseID: FBgn0038376
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_076221.1
• Gene: Abcb6 / 74104
• MGIID: 1921354
• Length: 842
• Species: Mus musculus
• Alignment Length: 848
• Identity: 439/848 - (51%)
• Similarity: 569/848 - (67%)
• Gaps: 39/848 - (4%)

  Fly     3 YCPPNVTLSEVWTQHGISHCFMDTVGPAVYGGFLLLFG--SIQLLMYRKYATRITDPTQIS---- 61
            ||.........|||:|:|.||..|:.|:.    ||..|  ::.|::.|:.......|.::|
Mouse     7 YCETEGPAGPAWTQNGLSPCFFFTLVPST----LLTLGVLALVLVLPRRRREVPAGPEELSWAAG 67

  Fly    62 -KSRLFAMQLFLLLL---LPVLALLRFLMNARIYPDSAVYGYMIFSTCVVCFSYPFSICLILKER 122
             :...:.:||||..|   ||:..|...:..||   ...:.||::.::.:...:....:.|::.||
Mouse    68 PRVAPYVLQLFLATLQMALPLAGLAGRVGTAR---GVRLPGYLLLASVLESLASVCGLWLLVVER 129

  Fly   123 YYQLPSMPTRG------HGLVLLLFWTLAFINESLAFINLRHEDWWFHLKTNKDQIEMGLFVTRF 181
            .....|: ..|      |.|.|||.||:.|..|:||.::.....||:.......|::.||:|.|:
Mouse   130 SQARQSL-AMGVWMKFRHSLGLLLLWTVTFAAENLALVSWNSPQWWWARADLGQQVQFGLWVLRY 193

  Fly   182 LCSLLIFVLGLKAPGIM-APYNPHQRLDNDTANESQG-NVQTGSAFRNGWRKLRTVFPYLWPKKN 244
            :.|..:|:|||.|||:. ..|..|...::.....:|| :....|.:|:..||||.:..||||:.:
Mouse   194 VTSGGLFILGLWAPGLRPQSYTLHVHEEDQDVGGNQGRSTDRRSTWRDLGRKLRLLSSYLWPRGS 258

  Fly   245 IALQIAVIVCIILLLAGRVIKLFLPIYRKKLVDSLTI-APIVFRWD----FVLIYVALSFLQGGG 304
            .:||:.|::|:.|:...|.:.:.:||:.:.:|:.||. ||    |.    .|..||.|.||||||
Mouse   259 PSLQLIVLICLGLMGLERALNVLVPIFYRDIVNLLTAKAP----WSSLAWTVTTYVFLKFLQGGG 319

  Fly   305 TGSMGLFNNLRTFLWIRVQQYTTREIEIELFRHLHQLSLRWHLQRKTGEVLRVMDRGTDSINNLL 369
            |||.|..:||||||||||||:|:|.:|:.||.|||:|||||||.|:||||||::||||.|:..||
Mouse   320 TGSTGFVSNLRTFLWIRVQQFTSRGVELRLFSHLHELSLRWHLGRRTGEVLRIVDRGTSSVTGLL 384

  Fly   370 NYIVFSIAPTILDLLVAVAYFVYAFNWWFGLIVFLTMFLYIASTIAITEWRTKYQRRMNLADNEQ 434
            :|:||||.||:.|:::.:.||...||.||||||||.|.||:..||.:||||.|::|.||..:|..
Mouse   385 SYLVFSIIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLILTIVVTEWRAKFRRDMNTQENAT 449

  Fly   435 RARSVDSLLNFETVKYYGAEHYEVDCYREAILKYQKEEFLSMLTLNMLNTAQNIILCLGLLAGSL 499
            |||:||||||||||||||||.||||.|||||||:|..|:.|..:|.:||..||:::.||||||||
Mouse   450 RARAVDSLLNFETVKYYGAEGYEVDRYREAILKFQGLEWKSTASLVVLNQTQNLVIGLGLLAGSL 514

  Fly   500 LCVYLVVHHQTLTVGDFVLFSTYLMELYMPLNWFGTYYRAIQKNFVDMENMFDLLKEEEEIVDAP 564
            ||.|. |..|.|.|||||||.||:.:|||||||||||||.||.||:||||||||||||.|:.|.|
Mouse   515 LCAYF-VSEQKLQVGDFVLFGTYITQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDVP 578

  Fly   565 GCSPLLTAGGGIEFSNVTFGYSPEKIVLRNVSFTVPAGKTVAIVGPSGAGKSTIMRLLFRFYDVQ 629
            |..||....|.|||.||.|.|:..:..|::|||||..|:|||:|||||||||||:||||||||:.
Mouse   579 GAGPLRFHKGRIEFENVHFSYADGQETLQDVSFTVMPGQTVALVGPSGAGKSTILRLLFRFYDIS 643

  Fly   630 TGAILIDGQNIKLVQQQSLRKAIGVVPQDTVLFNNTIFYNIEYAKLGASDEAVYEAARAADIHER 694
            :|.|.||||:|..|.|.|||..||||||||||||:||..||.|.::.|.|..|..||:||.||:.
Mouse   644 SGCIRIDGQDISQVTQISLRSHIGVVPQDTVLFNDTIANNIRYGRVTAGDSEVEAAAQAAGIHDA 708

  Fly   695 ILGFPEKYETKVGERGLRLSGGEKQRVAIARTLLKAPIIVLLDEATSALDTHTERNIQAALARVC 759
            ||.|||.|||:||||||:||||||||||||||:||||.|:|||||||||||..||.|||:||:||
Mouse   709 ILSFPEGYETQVGERGLKLSGGEKQRVAIARTILKAPDIILLDEATSALDTSNERAIQASLAKVC 773

  Fly   760 ANRTTIIVAHRLSTIIHADEILVLQQGSIAERGRHEELVLREDGIYADMW--QQQLKNLDAEQSG 822
            .|||||::||||||:::||:|||::.|.|.||||||.|:.| .|:||:||  |||.:....|:|.
Mouse   774 TNRTTIVIAHRLSTVVNADQILVIKDGCIIERGRHEALLSR-GGVYAEMWQLQQQGQETVPEESK 837

  Fly   823 GSD 825
            ..|
Mouse   838 PQD 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmt-1	NP_650503.1	MTABC_N	3..241	CDD:465049	73/255 (29%)
		ATM1	222..821	CDD:444078	372/605 (61%)
Abcb6	NP_076221.1	Required for ATPase activity. /evidence=ECO:0000250|UniProtKB:Q9NP58	1..236		65/236 (28%)
		Required for the lysosomal targeting. /evidence=ECO:0000250|UniProtKB:Q9NP58	1..205		57/205 (28%)
		MTABC_N	6..255	CDD:465049	73/255 (29%)
		ATM1	232..830	CDD:444078	371/603 (62%)