DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hmt-1 and CG10226

DIOPT Version :9

Sequence 1:	NP_650503.1	Gene:	Hmt-1 / 41925	FlyBaseID:	FBgn0038376	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster

Alignment Length:	703	Identity:	191/703 - (27%)
Similarity:	312/703 - (44%)	Gaps:	183/703 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 FVTRFLCSLLIFVLGLKAPGIMAPYNPHQRLDNDTANES-------QGNVQTGSAFRNGWRKLRT 234
            ||..||.| |:|.:.:.....:......:.|...|::.:       .|.:.|.:::....::||
  Fly    57 FVAAFLQS-LVFPIAIVVYSELVAMFIERTLGQGTSSVTIGLSLFGGGKILTNASYEENMQELR- 119

  Fly   235 VFPYLWPKKNIALQIAVIVCIILLLAGRVIKLFLPIYRKKLVDSLTIAPIVFRWDFVLIYVALSF 299
                   |.:::..       ||:....::.||..:|   .||:
  Fly   120 -------KDSVSFG-------ILMTLNTLLMLFSGVY---YVDA--------------------- 146

  Fly   300 LQGGGTGSMGLFNNLRTFLWIRVQQYTTREIEIELFRHLHQLSLRWH-LQRKTGEVLRVMDR--- 360
                       ||.|...|.:|:::        |.|:...:..:.|| :.:.....:|:.|.
  Fly   147 -----------FNRLALKLTVRMRR--------EFFKATLRQEIGWHDMAKDQNFAVRITDNMEK 192

  Fly   361 -GTDSINNLLNYIVFSIAPTILDLLVAVAY-FVYAFNWWFGLIVFLTMFLYIASTIAITEWRTKY 423
             .:....||.:|:     ..:.|::::|.. |:|.:.....::.::.:.|.:.|.:|      .|
  Fly   193 IRSGIAENLGHYV-----EIMCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVA------HY 246

  Fly   424 QRRMNLADNEQ----RARSV--DSLLNFETVKYYGAEHYEVDCYREAILKYQKEEFLSMLTLNML 482
            |.:  |...||    ||.||  :.:....||..:|.|       |...|:|.          ::|
  Fly   247 QGK--LTGQEQSSYVRASSVVEEVIGAIRTVVAFGGE-------RSESLRYD----------SLL 292

  Fly   483 NTAQNIILCLGLLAGSLLCVYLVVHHQTLTVGDFVLFSTYLMELYMPLNWFGT----YYR----- 538
            ..|.......|..:|           .:.||...:||.|.....     |:|.    |||
  Fly   293 KPALKAGKWKGAFSG-----------LSDTVMKAMLFITGAGSF-----WYGANLILYYRDPSIP 341

  Fly   539 ------------------AIQKNFVDMENMF---------------DLLKEEEEIVDAPGCSPLL 570
                              .:..|.:...:.|               |:: :...::|     ||.
  Fly   342 IDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVI-DRTSLID-----PLS 400

  Fly   571 TAG--------GGIEFSNVTFGYSPEK--IVLRNVSFTVPAGKTVAIVGPSGAGKSTIMRLLFRF 625
            .||        |.:||.:|.|.|...:  ||||.::..|..|:|||:|||||.||||.::||.||
  Fly   401 KAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRF 465

  Fly   626 YDVQTGAILIDGQNIKLVQQQSLRKAIGVVPQDTVLFNNTIFYNIEYAKLGASDEAVYEAARAAD 690
            ||...|.:|:||::::....:.||..|.||.|:.|||..:|..||.:.|..|:.:.|.:||:||:
  Fly   466 YDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAAN 530

  Fly   691 IHERILGFPEKYETKVGERGLRLSGGEKQRVAIARTLLKAPIIVLLDEATSALDTHTERNIQAAL 755
            .|:.|:...:.|:|.:.|:|::||||::||:||||.|::.|.|:||||||||||.|:|:.:||||
  Fly   531 AHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQAAL 595

  Fly   756 ARVCANRTTIIVAHRLSTIIHADEILVLQQGSIAERGRHEELVLREDGIYADM 808
            .:.|..|||::|:||||.|.||..|:.::.|...|:|.|||| ::.:|.|..|
  Fly   596 DKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEEL-MKLEGFYHKM 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmt-1	NP_650503.1	MTABC_N	3..241	CDD:292803	13/70 (19%)
		ABC_membrane	255..530	CDD:279056	53/286 (19%)
		ATM1	314..811	CDD:227590	168/559 (30%)
		ABCC_ATM1_transporter	576..812	CDD:213220	110/235 (47%)
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	184/678 (27%)
		ABC_membrane	<147..333	CDD:279056	48/239 (20%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	110/235 (47%)
		ABC_membrane	749..1019	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I2340
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.010