Protein Alignment Hmt-1 and ABCB7

DIOPT Version :10

• Sequence 1: NP_650503.1
• Gene: Hmt-1 / 41925
• FlyBaseID: FBgn0038376
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_728642.2
• Gene: ABCB7 / 38193
• FlyBaseID: FBgn0035244
• Length: 743
• Species: Drosophila melanogaster
• Alignment Length: 685
• Identity: 271/685 - (39%)
• Similarity: 396/685 - (57%)
• Gaps: 45/685 - (6%)

  Fly   185 LLIFVLGLKAPG--------------IMAPYNPHQRLDNDTANESQGNVQTGSAFRNGWRK---- 231
            ||..|.|.||.|              ...||.|.|:    .:.....::..||...:|..|
  Fly    71 LLGGVFGKKAKGGAPAAAAAKTTTLQRQRPYRPQQQ----QSRLCHVHIGGGSDGGSGLGKLDAP 131

  Fly   232 -------LRTVFPYLWPKKNIALQIAVIVCIILLLAGRVIKLFLPIYRKKLVDSLTIAPIVFRWD 289
                   ||.:..|:|||::..::..|.:.:.||...:::.:.:|...|..||::|...:....|
  Fly   132 EVTSKDMLRAMMAYIWPKEDPLVRKRVGISLGLLAGSKLLTVCVPFLFKGAVDTMTTLNMDTAPD 196

  Fly   290 FVL-IYVALSFLQGGGTGSMGLFNNLRTFLWIRVQQYTTREIEIELFRHLHQLSLRWHLQRKTGE 353
            .|| ...||....|....|...||.||..::.:|..::.|:|...:|.|||.|.|.:||.::||.
  Fly   197 AVLSAATALMLGYGIARASAAGFNELRNAVFAKVAHHSIRKIASNVFLHLHNLDLAFHLNKQTGA 261

  Fly   354 VLRVMDRGTDSINNLLNYIVFSIAPTILDLLVAVAYFVYAFNWWFGLIVFLTMFLYIASTIAITE 418
            :.:.:|||:..||.:|:.:||:|.|||.:|.:..:.........|..:....:.:|.|.|:::|:
  Fly   262 LSKTIDRGSRGINFVLSAMVFNIVPTIFELALVSSILGVKCGLAFAGVSMGCVGIYAAYTLSVTQ 326

  Fly   419 WRTKYQRRMNLADNEQRARSVDSLLNFETVKYYGAEHYEVDCYREAILKYQKEEFLSMLTLNMLN 483
            |||:::..||.|:||...::||||:|:|||||:..|.||..||.|.:.||:.....:..:|.:||
  Fly   327 WRTQFRVFMNQAENEAGNKAVDSLINYETVKYFNNEKYEAGCYNEVLKKYEAASLKTSSSLALLN 391

  Fly   484 TAQNIILCLGLLAGSLLCVYLV--VHHQTLTVGDFVLFSTYLMELYMPLNWFGTYYRAIQKNFVD 546
            ..||.|....|   ||:.|...  :....:||||.|:.:..|.:|.:||.:.|:.||.:::..:|
  Fly   392 FGQNAIFSSAL---SLIMVLAAKEIAQGNMTVGDLVMVNALLFQLSIPLGFLGSVYREVRQALLD 453

  Fly   547 MENMFDLLKEEEEIVDAPGCSPLL--TAGGGIEFSNVTFGYSPEKIVLRNVSFTVPAGKTVAIVG 609
            |..||.|:..:..|..|....||.  |....|||.||:|.|.|.|.:.|::|||:||||.|||||
  Fly   454 MRAMFTLMNVDSSIQTAANAQPLFVDTTNSSIEFRNVSFEYEPGKPIFRDLSFTIPAGKNVAIVG 518

  Fly   610 PSGAGKSTIMRLLFRFYDVQTGAILIDGQNIKLVQQQSLRKAIGVVPQDTVLFNNTIFYNIEYAK 674
            .||:|||:::||||||::..:|.:||.||:|..|..:||||.|.|||||:|||:|||.:||.|..
  Fly   519 GSGSGKSSMVRLLFRFFEPNSGKVLIGGQDISAVDLESLRKVIAVVPQDSVLFHNTIEHNIHYGN 583

  Fly   675 LGASDEAVYEAARAADIHERILGFPEKYETKVGERGLRLSGGEKQRVAIARTLLKAPIIVLLDEA 739
            |..|...|..|||.||:|:.|:.:|.:|.|:||||||:|||||||||||||.:||...|::.|||
  Fly   584 LSKSHAEVQNAARMADLHDSIMSWPGQYSTQVGERGLKLSGGEKQRVAIARAILKNTPILIFDEA 648

  Fly   740 TSALDTHTERNIQAALARVCANRTTIIVAHRLSTIIHADEILVLQQGSIAERGRHEELVLREDGI 804
            ||:||:.||.||..||.|..:.||:|.:||||||:..|||||||:.|.:.|||.|.|| ||::|:
  Fly   649 TSSLDSITEHNILQALTRATSGRTSICIAHRLSTVKDADEILVLENGRVGERGTHSEL-LRQNGL 712

  Fly   805 YADMWQQQLKNLDAEQSGGSDNGDASAESGSEKRR 839
            ||.:|:.|.:..|..:       :.:.|..::|.|
  Fly   713 YARLWETQTQQFDPSR-------EINEEVAAKKTR 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmt-1	NP_650503.1	MTABC_N	3..241	CDD:465049	18/80 (23%)
		ATM1	222..821	CDD:444078	257/614 (42%)
ABCB7	NP_728642.2	ATM1	147..732	CDD:444078	250/595 (42%)