DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hmt-1 and hmt1

DIOPT Version :9

Sequence 1:	NP_650503.1	Gene:	Hmt-1 / 41925	FlyBaseID:	FBgn0038376	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_588371.3	Gene:	hmt1 / 3361134	PomBaseID:	SPCC737.09c	Length:	830	Species:	Schizosaccharomyces pombe

Alignment Length:	850	Identity:	326/850 - (38%)
Similarity:	465/850 - (54%)	Gaps:	85/850 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VYGGFLLLFGSIQLLMYRKYATRITDP----TQISKSRLFAMQLFLLLLLPVLALLRFLMNARIY 91
            :|.||..: ||:.||..|| ||  :||    .:..|..:..:..::|.:  .|..:..:.|..||
pombe    18 LYVGFFSI-GSLNLLQKRK-AT--SDPYRRKNRFGKEPIGIISWWILGI--ALTYVVDISNLVIY 76

  Fly    92 PDSAVYGYMIFSTCVVC---FSYPFSICLILKERYYQLPSMP---TRGHGLVLLLFWTLAFINES 150
            . ..|..:....|.|||   |...:.|.||.......||...   .:.:.|.:|..|.:..:.|:
pombe    77 A-LRVPNWWPCKTTVVCLILFLLFWIIVLISCADSKALPKNADSILKAYRLSVLYVWAIDIVFET 140

  Fly   151 LAFINLRHEDWWFHLKTNKDQIEMGLFVTRFLCSLLIFVLGLKAPGIMAPY----NPHQRLD--- 208
            :..:...|.:..|          .|:.:...:..|::.|.   |..|...|    :.|..||
pombe   141 IFIVYSPHPNETF----------QGIVLADHVARLVLCVF---ATAIYLTYRRKRHTHDPLDFEE 192

  Fly   209 ---------NDTA-NESQGNVQTG--------------------SAFRNGWRKLRTVFPYLWPKK 243
                     |:.| :::...||.|                    .::...:|...|:.|||||.|
pombe   193 RQLTEESNVNENAISQNPSTVQLGVSASTSNFGTLKSTSKKPSDKSWAEYFRSFSTLLPYLWPTK 257

  Fly   244 NIALQIAVIVCIILLLAGRVIKLFLPIYRKKLVDSLTIAPIVFRWDFVLIYVALSFLQGGGTGSM 308
            :..||..:.:||:||..||.:.:..|.....|.:.||.......|..|:::|...|||    |:|
pombe   258 DYRLQFQIFICIVLLFLGRAVNILAPRQLGVLTEKLTKHSEKIPWSDVILFVIYRFLQ----GNM 318

  Fly   309 GLFNNLRTFLWIRVQQYTTREIEIELFRHLHQLSLRWHLQRKTGEVLRVMDRGTDSINNLLNYIV 373
            |:..:||:|||:.|.||..|.|..:..||:..||..:||.::.||||..:.:|: |:|.....:|
pombe   319 GVIGSLRSFLWVPVSQYAYRAISTKALRHVLNLSYDFHLNKRAGEVLTALTKGS-SLNTFAEQVV 382

  Fly   374 FSIAPTILDLLVAVAYFVYAFNWWFGLIVFLTMFLYIASTIAITEWRTKYQRRMNLADNEQRARS 438
            |.|.|.:|||.||:.||...|:.:|.|||.:....|...|:.||.|||:.:|:|..:..|..|..
pombe   383 FQIGPVLLDLGVAMVYFFIKFDIYFTLIVLIMTLCYCYVTVKITSWRTEARRKMVNSWRESYAVQ 447

  Fly   439 VDSLLNFETVKYYGAEHYEVDCYREAILKYQKEEFLSMLTLNMLNTAQNIILCLGLLAGSLLCVY 503
            .|:::||||||.:.|:.:|.:.|..|:..|.|:|...:.:||.||..|..|....|....||..|
pombe   448 NDAIMNFETVKNFDADDFENERYGHAVDIYLKQERKVLFSLNFLNIVQGGIFTFSLAIACLLSAY 512

  Fly   504 LVVHHQTLTVGDFVLFSTYLMELYMPLNWFGTYYRAIQKNFVDMENMFDLLKEEEEIVDAPGCSP 568
            .|..... ||||||:..||:::|..|||:|||.||::|.:.:|.|.:.::.:|:..:|:.|....
pombe   513 RVTFGFN-TVGDFVILLTYMIQLQQPLNFFGTLYRSLQNSIIDTERLLEIFEEKPTVVEKPNAPD 576

  Fly   569 LLTAGGGIEFSNVTFGYSPEKIVLRNVSFTVPAGKTVAIVGPSGAGKSTIMRLLFRFYDVQTGAI 633
            |....|.:.||:|:|.|.|.|.||.:::|....||.:|:||.||.|||||||:|.||:||.:|:|
pombe   577 LKVTQGKVIFSHVSFAYDPRKPVLSDINFVAQPGKVIALVGESGGGKSTIMRILLRFFDVNSGSI 641

  Fly   634 LIDGQNIKLVQQQSLRKAIGVVPQDTVLFNNTIFYNIEYAKLGASDEAVYEAARAADIHERILGF 698
            .||.|:|:.|...|||.:|||||||:.|||:||.|||:|||..|::|.:|.||:||.||:|||.|
pombe   642 TIDDQDIRNVTLSSLRSSIGVVPQDSTLFNDTILYNIKYAKPSATNEEIYAAAKAAQIHDRILQF 706

  Fly   699 PEKYETKVGERGLRLSGGEKQRVAIARTLLKAPIIVLLDEATSALDTHTERNIQAALARVCANRT 763
            |:.|.::||||||:||||||||||:||.:||.|.|:|||||||||||:|||.|||||.|:.:.||
pombe   707 PDGYNSRVGERGLKLSGGEKQRVAVARAILKDPSIILLDEATSALDTNTERQIQAALNRLASGRT 771

  Fly   764 TIIVAHRLSTIIHADEILVLQQGSIAERGRHEELVLREDGIYADMWQQQLKNLDAEQSGGSDNGD 828
            .|::|||||||.:||.||.:..|.|.|.|.||||:.|:.|.|..||.||..            |.
pombe   772 AIVIAHRLSTITNADLILCISNGRIVETGTHEELIKRDGGAYKKMWFQQAM------------GK 824

  Fly   829 ASAES 833
            .|||:
pombe   825 TSAET 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmt-1	NP_650503.1	MTABC_N	3..241	CDD:292803	55/256 (21%)
		ABC_membrane	255..530	CDD:279056	102/274 (37%)
		ATM1	314..811	CDD:227590	241/496 (49%)
		ABCC_ATM1_transporter	576..812	CDD:213220	141/235 (60%)
hmt1	NP_588371.3	ATM1	1..404	CDD:227590	113/410 (28%)
		ABC_membrane	269..538	CDD:279056	102/274 (37%)
		ATM1	324..819	CDD:227590	241/496 (49%)
		ABCC_ATM1_transporter	584..820	CDD:213220	141/235 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	191	1.000	Domainoid score	I717
eggNOG	1	0.900	-	-		E1_COG5265
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11375
Inparanoid	1	1.050	521	1.000	Inparanoid score	I220
OMA	1	1.010	-	-		QHG54509
OrthoFinder	1	1.000	-	-		FOG0004593
OrthoInspector	1	1.000	-	-		oto101440
orthoMCL	1	0.900	-	-		OOG6_100761
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3271
SonicParanoid	1	1.000	-	-		X3206
TreeFam	1	0.960	-	-
	13	12.760