DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hmt-1 and Abcb7

DIOPT Version :9

Sequence 1:	NP_650503.1	Gene:	Hmt-1 / 41925	FlyBaseID:	FBgn0038376	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_997683.1	Gene:	Abcb7 / 302395	RGDID:	1303086	Length:	752	Species:	Rattus norvegicus

Alignment Length:	629	Identity:	261/629 - (41%)
Similarity:	367/629 - (58%)	Gaps:	35/629 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 LRTVFPYLWPKKNIALQIAVIVCIILLLAGRVIKLFLPIYRKKLVDSL---------------TI 281
            ::.:..|:|||....|:..|.:.:..|...:.:.:.:|...|..||||               |:
  Rat   121 IKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLSDAPNTV 185

  Fly   282 APIVFRWDFVLIYVALSFLQGGGTGSMG--LFNNLRTFLWIRVQQYTTREIEIELFRHLHQLSLR 344
            |.           :|.:.|.|.|....|  .||.:|..::.:|.|.:.|.|...:|.|||.|.|.
  Rat   186 AT-----------MATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG 239

  Fly   345 WHLQRKTGEVLRVMDRGTDSINNLLNYIVFSIAPTILDLLVAVAYFVYAFNWWFGLIVFLTMFLY 409
            :||.|:||.:.:.:||||..|:.:|:.:||::.|.:.::.:..:...|.....|.|:...|:..|
  Rat   240 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIVFEMTLVSSVLYYKCGAQFALVTLGTLGAY 304

  Fly   410 IASTIAITEWRTKYQRRMNLADNEQRARSVDSLLNFETVKYYGAEHYEVDCYREAILKYQKEEFL 474
            .|.|:|:|.|||:::..||.|||:....::|||||:|||||:..|.||...|...:..|:.....
  Rat   305 TAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNEKYEAQRYDGFLKTYETASLK 369

  Fly   475 SMLTLNMLNTAQNIILCLGLLAGSLLCVYLVVHHQTLTVGDFVLFSTYLMELYMPLNWFGTYYRA 539
            |..||.|||..|:.|..:||.|..:|....:| ...|||||.|:.:..|.:|.:|||:.||.||.
  Rat   370 STSTLAMLNFGQSAIFSVGLTAIMVLASQGIV-AGALTVGDLVMVNGLLFQLSLPLNFLGTVYRE 433

  Fly   540 IQKNFVDMENMFDLLKEEEEIVDAPGCSPL----LTAGGGIEFSNVTFGYSPEKIVLRNVSFTVP 600
            .::..:||..:|.|||.:..|.|....|||    .||  .:.|.||.|.|...:.||..|||.||
  Rat   434 TRQALIDMNTLFTLLKVDTRIKDKAMASPLQITPQTA--TVAFDNVHFEYIEGQKVLSGVSFEVP 496

  Fly   601 AGKTVAIVGPSGAGKSTIMRLLFRFYDVQTGAILIDGQNIKLVQQQSLRKAIGVVPQDTVLFNNT 665
            |||.|||||.||:|||||:|||||||:.|.|:|.:.||||:.|..:|||:|:||||||.|||:||
  Rat   497 AGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNT 561

  Fly   666 IFYNIEYAKLGASDEAVYEAARAADIHERILGFPEKYETKVGERGLRLSGGEKQRVAIARTLLKA 730
            |:||:.|..:.||.|.||..|:.|.:|:.||..|..|:|:||||||:|||||||||||||.:||.
  Rat   562 IYYNLLYGNINASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKD 626

  Fly   731 PIIVLLDEATSALDTHTERNIQAALARVCANRTTIIVAHRLSTIIHADEILVLQQGSIAERGRHE 795
            |.::|.|||||:||:.||..|..|:..|..:||:|.:||||||::.||||:||.||.:||||.|.
  Rat   627 PPVILYDEATSSLDSITEETILGAMRDVVKHRTSIFIAHRLSTVVDADEIIVLSQGKVAERGTHY 691

  Fly   796 ELVLREDGIYADMWQQQLKNLDAEQSGGSDNGDASAESGSEKRR 839
            .|:.....||::||..|...:....:.|.|....|.....|:::
  Rat   692 GLLANSSSIYSEMWHTQSTRIQNHDNLGWDAKKESLSKEEERKK 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmt-1	NP_650503.1	MTABC_N	3..241	CDD:292803	1/8 (13%)
		ABC_membrane	255..530	CDD:279056	94/291 (32%)
		ATM1	314..811	CDD:227590	234/500 (47%)
		ABCC_ATM1_transporter	576..812	CDD:213220	136/235 (58%)
Abcb7	NP_997683.1	ABC_membrane	150..424	CDD:279056	93/285 (33%)
		ATM1	210..705	CDD:227590	232/497 (47%)
		Glutathione binding. /evidence=ECO:0000250\|UniProtKB:P40416	315..319		2/3 (67%)
		Glutathione binding. /evidence=ECO:0000250\|UniProtKB:P40416	378..381		1/2 (50%)
		ABCC_ATM1_transporter	472..708	CDD:213220	136/235 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248727at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920